Case reports of hypercalcemia and chronic renal disease due to cosmetic injections of polymethylmethacrylate (PMMA)

Abstract

Cosmetic injections of fillers are common plastic surgery procedures worldwide. Polymethylmethacrylate (PMMA) is a filler approved only for minimally invasive procedures in facial tissue and is among the most frequently used injectable substances for cosmetic purposes. Injection of a large volume of PMMA may lead to the development of severe hypercalcemia and chronic kidney damage in a probably underestimated frequency. In such cases, hypercalcemia develops due to a granulomatous foreign body reaction with extrarenal production of calcitriol. In the present report, we describe the cases of two patients who received injections of large volumes of PMMA and developed severe hypercalcemia and advanced chronic kidney disease. These reports highlight the importance of adhering to regulations regarding the use of PMMA and properly informing patients of the possibility of complications before undertaking such procedures.

Reações do PMMA nos procedimentos estéticos faciais

“…A importância da dosagem do PMMA é fundamental, e injeções de preenchimento estético é comum na estética, porém o PMMA é aprovado apenas para procedimentos minimamente invasivos no tecido facial, e se for usado em grande volume pode ocasionar hipercalcemia grave e lesão renal crônica no paciente, causando risco a vida (MANFRO et al, 2021).…”