2020
DOI: 10.1186/s12879-020-04971-2
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Case reports of latent HBV hepatitis in patients after neurosurgical treatment for hypothalamic and pituitary tumors

Abstract: Background: Hepatitis B virus (HBV) infection is a major public health problem worldwide. More than 2 billion people have been exposed to HBV, and about 257 million individuals are chronic carriers of HBV. HBV reactivation has been increasingly reported in HBV carriers who have undergone immunosuppression or chemotherapy, resulting in mortality. Treatment of hypothalamic/pituitary tumors in HBV carriers requires extensive care to avoid HBV reactivation as steroid therapy is required after surgery for hypothala… Show more

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Cited by 4 publications
(4 citation statements)
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“…The course of the inactive HBsAg carrier stage is usually benign. However, this stage carries a 20–30% risk of spontaneous reactivation and liver cancer [ 6 ].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The course of the inactive HBsAg carrier stage is usually benign. However, this stage carries a 20–30% risk of spontaneous reactivation and liver cancer [ 6 ].…”
Section: Discussionmentioning
confidence: 99%
“…The virus genotype and the viral DNA in blood, as well as some patient factors (age, sex, genetic factors, immune status), seem to determine who will develop these outcomes. The prognosis of chronic hepatitis B infection depends on the severity of liver injury [ 6 ].…”
Section: Introductionmentioning
confidence: 99%
“…The World Health Organisation (WHO) has described the Hepatitis B classification as a major health challenge that causes a chronic infection exposing people to a high risk of deaths as a result of cirrhosis and liver cancer (WHO, 2016b). Globally, although 2 billion people retrospectively have traces of HBV infection, an estimated 257 million people are noted to be living with the chronic type (Niizuma et al, 2020;WHO, 2017b). Approximately, 887,000 deaths were reported to have resulted from HBV in the year 2015 (Hyun et al, 2019).…”
Section: Introductionmentioning
confidence: 99%
“…Globally distributed herpesviruses and hepatitis viruses are of greatest concern because of the burden of disease and death they cause and the potential for outbreaks and epidemics [34,35]. These viruses have a latent form in their infectious cycle [36,37] that is resistant to known therapeutic agents. Moreover, latent human or animal viruses can contribute significantly to graft rejection in transplantation [38] or xenotransplantation [39].…”
mentioning
confidence: 99%