Case Reports of Pregnancy-Related Cerebral Venous Thrombosis in the Neurology Department of the Emergency Clinical Hospital in Constanta

Abstract

Cerebral venous thrombosis accounts for 0.5–1% of all cerebrovascular events and is one type of stroke that affects the veins and cerebral sinuses. Females are more affected than males, as they may have risk factors, such as pregnancy, first period after pregnancy, treatment with oral contraceptives treatment with hormonal replacement, or hereditary thrombophilia. This neurological pathology may endanger a patient’s life. However, it must be suspected in its acute phase, when it presents with variable clinical characteristics, so that special treatment can be initiated to achieve a favorable outcome with partial or complete functional recovery. The case study describes the data and the treatment of two patients with confirmed cerebral venous thrombosis with various localizations and associated risk factors, who were admitted to the neurology department of the Sf. Apostol Andrei Emergency Hospital in Constanta. The first patient was 40 years old and affected by sigmoid sinus and right lateral sinus thrombosis, inferior sagittal sinus, and right sinus thrombosis, associated with right temporal subacute cortical and subcortical hemorrhage, which appeared following a voluntary abortion. The second case was a patient aged 25 who was affected by left parietal cortical vein thrombosis, associated with ipsilateral superior parietal subcortical venous infarction, which appeared following labor. The data are strictly observational and offer a perspective on clinical manifestations and clinical and paraclinical investigations, including the treatment of young patients who had been diagnosed with cerebral venous thrombosis and admitted to the neurology department.

The risk profiles of pregnancy-related cerebral venous thrombosis: a retrospective study in a comprehensive hospital

“…Previous case reports or series show that anemia, obesity, smoking, cesarean section, epidural and spinal anesthesia during childbirth, pregnancy-induced hypertension, ovarian stimulation drugs, infections, Hyperhomocysteinemia (HHCY), antiphospholipid antibodies (aPL), and SLE may be closely associated with PCVT [7][8][9][10][11][12]. Several articles have described hereditary thrombophilia such as Factor V Leiden mutation (FVL), proteins C (PC) and protein S (PS), antithrombin III (ATIII) deficiency in PCVT [12][13][14][15][16][17][18][19][20][21][22]. However, these existing studies have not comprehensively analyzed the risk factors or etiology of PCVT, and the research is mainly conducted in European countries, India, and other countries, while there are a few studies in China which do not mention the acquired and genetic thrombophilia of PCVT, indicating a knowledge gap in this area [23][24][25][26].…”