Case Reports: Pseudomelanosis Duodeni: Association With Systemic Hypertension

El-Newihi, Hussein M.; Lynch, Cynthia A.; Mihas, Anastasios A.

doi:10.1097/00000441-199531030-00005

Cited by 8 publications

(10 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gastric and duodenal pseudomelanosis (GDP) is a benign and infrequent condition of uncertain clinical significance and it is associated with a variety of clinical conditions and intake of several medications [ 1 , 2 ]. The condition was first described in 1976 by Bisordi and Kleinman [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Gastric and Duodenal Pseudomelanosis: An Extended Unusual Finding in a Patient with End Stage Kidney Disease

Qureshi

Younus

Alavi

et al. 2016

Case Reports in Gastrointestinal Medicine

View full text Add to dashboard Cite

Gastric and duodenal pseudomelanosis is a rare endoscopic mucosal finding, characterized by the accumulation of iron in macrophages of the lamina propria of the stomach and duodenum. The clinical significance and long term sequelae have not been clarified yet. However, this benign condition is associated with a variety of clinical conditions, such as essential hypertension, chronic renal failure, diabetes mellitus, long term intake of iron supplements, and furosemide. Duodenal pseudomelanosis appears to be more common than gastric pseudomelanosis given the fact that a few cases of gastric pseudomelanosis have been reported in the literature so far. We report a case of 88-year-old lady with ESRD who is maintained on hemodialysis and presented with abdominal pain. An upper GI endoscopy showed discoloration of the antrum of the stomach and most portion of her duodenum. Histopathology report confirmed the presence of iron laden macrophages in the lamina propria of both stomach and duodenum.

show abstract

Section: Introductionmentioning

confidence: 99%

Gastric and Duodenal Pseudomelanosis: An Extended Unusual Finding in a Patient with End Stage Kidney Disease

Qureshi

Younus

Alavi

et al. 2016

Case Reports in Gastrointestinal Medicine

View full text Add to dashboard Cite

show abstract

“…There has been few similar cases reported, and it was shown that Pseudomelanosis Duodeni is more predominant in females in their sixties and seventies. Although correlations with drug use (Charcoal, hydralazine, furosemide, hydrochlorothiazide, propranolol, and iron supplements) and systemic diseases (hypertension, chronic renal disease, gastric hemorrhage, and diabetes mellitus) have been noted, the etiology of Pseudomelanosis Duodeni has not been yet elucidated [5], [6], [7].…”

Section: Discussionmentioning

confidence: 99%

Pseudomelanosis Duodeni: An Interesting and Rare Finding At Upper G.I. Endoscopy

Alameri¹,

Al-Bayati²,

Ahmed³

2017

JSD

View full text Add to dashboard Cite

Pseudomelanosis Duodeni is an incidental endoscopic finding that is seen as splotches of brown-black pigment of the duodenal mucosa. Only a few cases have been reported. Sometimes it was found to be associated with certain medications and systemic diseases. It is a benign condition and does not seem to have clinical consequences but needs to be recognized to distinguish it from more serious conditions like Malignant Melanoma.

show abstract

“…Various ancillary histochemical stains can also be utilized to help visualize and characterize the pigment, including Masson-Fontana stain and Perls' "Prussian Blue" stain for melaninlike compounds and iron sulfide, respectively. [22][23][24][25] However, no clear explanation exists for their co-occurrence. 13,16 The exact etiology and pathogenesis for this aberrant pigment deposition is still unclear.…”

Section: Discussionmentioning

confidence: 99%

“…12 However, Perls' stain can give a false-negative reaction if ferrous oxide is present instead of ferrous sulfide. [22][23][24] Among these medications, hydralazine, furosemide, and hydrochlorthiazide contain sulfur, which is postulated to promote pigment deposition in the duodenum. Possible explanations for pseudomelanosis include abnormal iron accumulation secondary to oral iron intake or mucosal bleeding inside the upper gastrointestinal tract.…”

Section: Discussionmentioning

confidence: 99%

Pseudomelanosis of Stomach, Duodenum, and Jejunum

Rustagi

Mansoor²,

Gibson³

et al. 2015

Journal of Clinical Gastroenterology

View full text Add to dashboard Cite

Pseudomelanosis is a rare finding during upper gastrointestinal endoscopy, and is most commonly seen in the duodenum. Involvement of other organs in the upper gastrointestinal tract is extremely rare, with only 1 reported case involving the stomach, duodenum, and jejunum. We present a case of a 60-year-old woman with mild anemia and hematemesis, who was found to have characteristic speckled pattern of gray-black pigmentation on endoscopic examination. To the best of our knowledge, this is the second reported case of pseudomelanosis involving the stomach, duodenum, and jejunum.

show abstract

Case Reports: Pseudomelanosis Duodeni: Association With Systemic Hypertension

Cited by 8 publications

References 18 publications

Gastric and Duodenal Pseudomelanosis: An Extended Unusual Finding in a Patient with End Stage Kidney Disease

Gastric and Duodenal Pseudomelanosis: An Extended Unusual Finding in a Patient with End Stage Kidney Disease

Pseudomelanosis Duodeni: An Interesting and Rare Finding At Upper G.I. Endoscopy

Pseudomelanosis of Stomach, Duodenum, and Jejunum

Contact Info

Product

Resources

About