Case selection in minimally invasive surgical treatment of neuroblastoma

Boutros, John; Bond, Mason; Beaudry, Paul; Blair, Geoffrey K.; Skarsgard, Erik D.

doi:10.1007/s00383-008-2240-7

Cited by 15 publications

(8 citation statements)

References 22 publications

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“…In a study of 39 children with >97% 5‐year survival, authors suggest that MIS should be the preferred method of resection for neuroblastomas without any risk factors such as vascular encasement, dumbbell configuration, or infiltration of important surrounding structures defined on imaging . In a single institutional study from Canada, authors suggested that abdominal neuroblastomas should be confined to the organ of origin (INSS stage 1 or 2), show a significant cytoreductive response if more advanced (INSS stage 3 or 4), and must not encase major vascular structures . For neuroblastomas of the posterior mediastinum, they suggested that localized, encapsulated tumors without significant transforaminal extension are amenable to thoracoscopic resection.…”

Section: Discussionmentioning

confidence: 99%

Comparing oncologic outcomes after minimally invasive and open surgery for pediatric neuroblastoma and Wilms tumor

Ezekian

Englum

Gulack

et al. 2017

Pediatric Blood & Cancer

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Background: Minimally invasive surgery (MIS) has been widely adopted for common operations in pediatric surgery; however, its role in childhood tumors is limited by concerns about oncologic outcomes. We compared open and MIS approaches for pediatric neuroblastoma and Wilms tumor (WT) using a national database. Methods Conclusion:Our retrospective review suggests that the use of MIS appears to be a safe method of oncologic resection for select children with neuroblastoma and WT. Further research should clarify which children are the optimal candidates for this approach.

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Section: Discussionmentioning

confidence: 99%

Comparing oncologic outcomes after minimally invasive and open surgery for pediatric neuroblastoma and Wilms tumor

Ezekian

Englum

Gulack

et al. 2017

Pediatric Blood & Cancer

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“…In other cases, surgical biopsy is a safer choice for making a histological diagnosis in patients with PNTs that cannot be resected completely at one time. However, in experienced hands, minimally invasive surgery is a safe technique with a short hospitalization stay and minimal complications (34)(35)(36). In our series, 26 patients were open resected, while two patients underwent a laparoscopic surgery; the 15 remaining patients were biopsied.…”

Section: Discussionmentioning

confidence: 88%

Clinical Characteristics of Peripheral Neuroblastic Tumors in Children: A Single-Center Experience of 43 Cases

Lin

Chen

et al. 2018

Iran J Pediatr

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Background: The true incidence of peripheral neuroblastic tumors (PNTs) in children is unknown. This study aims to review and analyze clinical data on the diagnosis and management of pediatric PNTs. Methods: Between 2007 and 2016, a total of 43 pediatric patients admitted to our institute with PNTs were reviewed. Results: The series comprised of 23 males and 20 females with a median age of 1.2 years old. Among the 43 PNTs, 26 tumors originated from the abdomen, 13 from the thorax and four from other primary sites. A total of 16 tumors were identified in routine examinations. Abdominal pain and distension were the main clinical manifestations of abdominal PNTs, while coughing was the most frequent presenting symptom of thoracic PNTs. Elevated vanillylmandelic acid level in the urine over 24 hours was observed in 18 neuroblastoma cases and three ganglioneuroblastoma cases. Neuroblastoma was the most common type of PNT that was reported in 30 (69.8%) patients, followed by ganglioneuroblastoma, which was diagnosed in 11 (25.6%) patients. Only 2 (4.6%) patients were diagnosed with ganglioneuroma. A total of 12 cases were stage, six cases were stage II, three cases were stage III, 18 cases were stage IV, and four cases were stage IVs. The overall two year survival rate was 62.9%, which was related to pathological type, Shimada classification, stage, and primary site. Conclusions: Pediatric PNTs have different clinical characteristics and outcomes. Imaging and laboratory data may be useful for the differentiation of PNTs. This study will help pediatric surgeons be aware of the possible manifestations of PNTs in children.

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“…2,10,12,14,32,62 Complete resection of intrathoracic neurogenic tumors has been reported in 70%-100% of cases for lesions up to 18 cm in size. 2,9,10,12,14,32,47,[62][63][64] In addition to neurogenic tumors, other mediastinal masses have been successfully resected thoracoscopically, including lymphoma, 64 teratoma, 56,64 and thymoma. 64 Gross total thoracoscopic resection of neurogenic tumors has been performed, 9,10,12,62 and when compared with the open thoracotomy group, they were significantly smaller, 12 were associated with up to 75% less intraoperative blood loss, 9,10 had up to 19% shorter operative times, 10 had 33%-50% decreased time of thoracic drainage, 9,12 and had up to 54% decreased hospital LOS.…”

Section: Mediastinal Lesionsmentioning

confidence: 98%

“…During resection of a thoracic neurogenic tumor, grossly positive tumor margins were present at the neural foramina because of planned division without intention to resect the intraforaminal disease; despite this anticipated positive margin there was no difference between the thoracoscopic and open thoracotomy groups. 10 Conversion to open thoracotomy was under 45% 9,12,14,25,32,47,63,64 and was primarily due to extensive disease, 64 bleeding, 47 large size, 2 and difficulty with single-lung ventilation. 10 Chest tube drainage was not required in up to 35% of patients.…”

Section: Mediastinal Lesionsmentioning

confidence: 99%

The Role of Thoracoscopic Surgery in Pediatric Oncology

Malkan

Loh

Fernández-Pineda

et al. 2014

Journal of Laparoendoscopic & Advanced Surgical Techniques

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The application of thoracoscopic surgical techniques to pediatric solid tumors represents an important adjunctive tool for the surgical management of childhood cancer. Nearly four decades has passed since the introduction of minimally invasive chest surgery in children, and although the adoption of minimally invasive surgery in general pediatric surgical practice is better recognized, its role in pediatric oncology is still considered a developing field. As no consensus exists regarding the use of thoracoscopy for pediatric thoracic solid tumors, the purpose of this article is to review the current literature surrounding the use of thoracoscopic interventions in pediatric oncology and examine established indications, procedures, and technologic advances.

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Case selection in minimally invasive surgical treatment of neuroblastoma

Abstract: With appropriate preoperative case selection based on anatomic features, MIS tumor resection in patients with NB can be performed safely and effectively.

Cited by 15 publications

References 22 publications

Comparing oncologic outcomes after minimally invasive and open surgery for pediatric neuroblastoma and Wilms tumor

Comparing oncologic outcomes after minimally invasive and open surgery for pediatric neuroblastoma and Wilms tumor

Clinical Characteristics of Peripheral Neuroblastic Tumors in Children: A Single-Center Experience of 43 Cases

The Role of Thoracoscopic Surgery in Pediatric Oncology

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