Case Series and Literature Review of Ophthalmologic Disorders Seen in a Specialist Rheumatology Clinic in Lagos, Nigeria

Adelowo, Olufemi; Akpabio, Akpabio A; Oderinlo, Olufemi; Okonkwo, Ogugua Ndubuisi; Raphael, John

doi:10.1080/09273948.2019.1611873

Cited by 4 publications

(6 citation statements)

References 26 publications

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“…Similar studies have reported ophthalmological manifestations in 2–7.7% of their studied population. 16 , 17 , 20 Recently, a systematic review with meta-analysis by Turk et al 21 corroborates our data, as it shows that the ocular involvement in ADs is between 20–33%. These differences may be attributed to the inclusion of a greater number of rheumatologic diseases and ophthalmological diagnoses and symptoms compared to the mentioned similar studies.…”

Section: Discussionsupporting

confidence: 85%

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Ocular Manifestations in Colombian Patients with Systemic Rheumatologic Diseases

Uribe-Reina¹,

Muñoz-Ortíz²,

Cifuentes-González³

et al. 2021

OPTH

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Purpose To establish the prevalence of ocular involvement in a Colombian population with rheumatologic diseases. Design Observational cross-sectional study. Methods We included a probabilistic sample size of 797 patients who attended a rheumatologic disease center in Bogotá, Colombia. Statistical analysis with descriptive measures and Chi-square independence test between rheumatologic diseases and ophthalmological symptoms and diseases was performed. Results Eighty-four percent of the population were women, and the mean age was 54.61± 15.64 years. The most common condition was rheumatoid arthritis (33.37%), followed by fibromyalgia (22.71%), Sjögren Syndrome (19.72%), and systemic lupus erythematosus (9.91%). Almost 7% of the patients presented polyautoimmunity. Thirty-five percent of the patients reported one or more ophthalmological symptoms, being dry eye sensation the most common (30.86%), followed by ocular pain (2.76%), red-eye, and decreased visual acuity (both 2.63%). Similarly, 21.45% of the patients presented one or more ophthalmological diagnoses, being keratoconjunctivitis sicca the most common (15.93%), followed by cataract, uveitis (1.38% each), and scleritis (1.25%). Conclusion Almost a third of the patients reported any ocular involvement. It is crucial to be aware of the most common ophthalmic manifestations among the different rheumatologic diseases in our population, to offer early specialist referral and timely treatment.

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Section: Discussionsupporting

confidence: 85%

“…Similarly, the mean ages of 44.3 ± 13.7 and 48.9 ± 19.3 have been reported in comparable studies. 19 , 20 Contrarily, one study reported a mean age of 67.6 ± 14.5. 16 …”

Section: Discussionmentioning

confidence: 99%

Ocular Manifestations in Colombian Patients with Systemic Rheumatologic Diseases

Uribe-Reina¹,

Muñoz-Ortíz²,

Cifuentes-González³

et al. 2021

OPTH

View full text Add to dashboard Cite

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“…Based on other studies, autoimmune diseases are far more common among females; similarly, in our study, most of the patients were also females (67%), and gender was not associated with immune‐mediated rheumatologic diseases in our study ( p ‐value = .085); this event might be because of our small sample size 15–17 . We found that the mean age was 40.43 ± 13.26 years in our participants; Adelowo et al and Pathanapitoon et al reported the age of the participants 44.3 ± 13.7 and 48.9 ± 19.3 years, respectively, which were similar to our study; still, Uribe‐Reina et al have reported the mean age 54.6 ± 15.6 years, which was higher than our results 15,18,19 …”

Section: Discussionsupporting

confidence: 66%

“…[15][16][17] We found that the mean age was 40.43 ± 13.26 years in our participants; Adelowo et al and Pathanapitoon et al reported the age of the participants 44.3 ± 13.7 and 48.9 ± 19.3 years, respectively, which were similar to our study; still, Uribe-Reina et al have reported the mean age 54.6 ± 15.6 years, which was higher than our results. 15,18,19 Although approximately half of our participants were older than 40, only 16 patients reported comorbidities, and the comorbidities were not statistically associated with rheumatologic disease history (p-value = .198). Involvement of a singular eye was more common (56.6%) than involvement of both eyes (43.40%), but the involvement of both eyes was more common than the isolated left or right eye involvement.…”

Section: Discussionmentioning

confidence: 81%

“… 15 , 16 , 17 We found that the mean age was 40.43 ± 13.26 years in our participants; Adelowo et al and Pathanapitoon et al reported the age of the participants 44.3 ± 13.7 and 48.9 ± 19.3 years, respectively, which were similar to our study; still, Uribe‐Reina et al have reported the mean age 54.6 ± 15.6 years, which was higher than our results. 15 , 18 , 19 …”

Section: Discussionmentioning

confidence: 99%

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Ocular manifestations in Iranian patients referred to rheumatology clinics from 2018 to 2020

Pournazari

Hashemi

Zarpoosh

et al. 2023

Immunity Inflam & Disease

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Aim Autoimmune diseases are presented with many signs and symptoms. Eyes are commonly involved in these diseases. This study aimed to estimate the prevalence of different ophthalmological complications in patients with and without immune‐mediated rheumatological diseases. Methods Patients who were referred to Kermanshah's rheumatologic clinics by an ophthalmologist from 2018 to 2020 for a rheumatologist visit were included. A checklist for extracting data from medical files; containing symptoms, organ involvement, ocular diseases diagnosed by an ophthalmologist, rheumatologic diseases diagnosed by a rheumatologist, lab tests, and disease progression was created. After we evaluated the medical data, we found that 54 patients out of 106 were diagnosed to have immune‐mediated rheumatological diseases. Patients were divided into two groups; the first group included patients with diagnosed immune‐mediated rheumatologic disease and ophthalmic complications; patients with no known immune‐mediated rheumatological disease were considered the second group. The obtained information was analyzed using statistical tests. Results One hundred and six patients participated in this study, 67% of whom were females. The most common ocular symptom was blurred vision (49%). Involvement of both eyes (43.4%) was more common than single left or right eye involvement. The most common ophthalmic disease was anterior uveitis (35.8%). The most common rheumatologic disease was Behçet's disease (21.7%). Hypertension and hypothyroidism were the most common comorbidities; 36.7% of the patients had skin and mucous involvement, and 37.7% had joint involvement. In follow‐up of the ophthalmic symptoms, most patients were controlled partially. Ophthalmic diseases, laboratory tests, joint involvement, skin and mucous involvement, and lung involvement were associated with rheumatologic diseases. Conclusion Early diagnosis of ocular involvement in rheumatologic diseases is crucial to prevent adverse complications. The results can be beneficial for a better perception of ophthalmic symptoms and diseases among patients with autoimmune diseases.

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Clinical characteristics and aetiology of uveitis in a viral haemorrhagic fever zone

Balendra,

Harrison-Williams,

Mustapha

et al. 2024

Eye

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Background/Objectives Studies on uveitis in Sierra Leone were conducted prior to the Ebola Virus Disease epidemic of 2013–16, which was associated with uveitis in 20% of survivors. They did not include imaging or investigation of tuberculosis and used laboratory services outside the country. We performed a cross-sectional study on patients presenting with uveitis to establish their clinical characteristics and identify the impact of in-country laboratory diagnoses. Methods We invited uveitis cases presenting to Eye Clinics in Sierra Leone from March to September 2022 to participate in the study. They underwent a diagnostic work-up, including fundus and ocular coherence tomography imaging. Active uveitis cases underwent further investigations including serology and immunological tests for syphilis, tuberculosis, herpetic viruses and HIV and chest radiographs. Results We recruited 128 patients. The median age was 34 (IQR 19) years and there was an equal gender split. Panuveitis was the predominant anatomical uveitis type (n = 51, 40%), followed by posterior uveitis (n = 36, 28%). Bilateral disease affected 40 patients (31%). Active uveitis was identified in 75 (59%) cases. ICD 11 definition of blindness with VA < 3/60 occurred in 55 (33%) uveitis eyes. Aetiology of uveitis from clinical and laboratory assessment demonstrated that most cases were of undifferentiated aetiology (n = 66, 52%), followed by toxoplasmosis (n = 46, 36%). Trauma contributed to eight (6%) cases, syphilis to 5 (4%) cases and Ebola to 2 (2%). Conclusions Uveitis was associated with high levels of visual impairment. Posterior and panuveitis contributed to the highest proportion of uveitis cases. Laboratory studies helped differentiate syphilis as a significant aetiology of uveitis.

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Case Series and Literature Review of Ophthalmologic Disorders Seen in a Specialist Rheumatology Clinic in Lagos, Nigeria

Cited by 4 publications

References 26 publications

Ocular Manifestations in Colombian Patients with Systemic Rheumatologic Diseases

Ocular Manifestations in Colombian Patients with Systemic Rheumatologic Diseases

Ocular manifestations in Iranian patients referred to rheumatology clinics from 2018 to 2020

Clinical characteristics and aetiology of uveitis in a viral haemorrhagic fever zone

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