Case Series of Thrombosis With Thrombocytopenia Syndrome After COVID-19 Vaccination—United States, December 2020 to August 2021

Abstract

Using the Vaccine Adverse Event Reporting System, the number and demographic characteristics of cases of thrombosis with thrombocytopenia syndrome occurring after receipt of COVID-19 vaccines in the United States were determined.

Use of the Janssen (Johnson & Johnson) COVID-19 Vaccine: Updated Interim Recommendations from the Advisory Committee on Immunization Practices — United States, December 2021

“…Physicians at CDC and FDA confirmed whether each report met the CDC case definition for TTS ¶ through medical record review, with input from Clinical Immunization Safety Assessment Project investigators,** including hematologists. A detailed review of TTS cases with vaccination occurring before August 31, 2021, including a description of rates, patient characteristics, and clinical course, was presented to ACIP and used in the benefit-risk analysis (8).…”

“…1). Among persons who received primary Janssen COVID-19 vaccination by August 31, 2021, eight TTS deaths occurred † † (8). Six deaths occurred in women, and two in men.…”

“…Among 130 patients with preliminary reports of GBS after Janssen COVID-19 vaccination through July 24, 2021, one (0.8%) patient died, and 18 (14%) had respiratory compromise or failure (10). Among 54 TTS cases after Janssen COVID-19 vaccination, eight (15%) patients died, and an additional nine (17%) required discharge to postacute care or a rehabilitation facility (8). The estimated benefits of the Janssen COVID-19 vaccine outweighed the risks when compared with no vaccine for all persons aged ≥18 years (Table 2).…”

Brain Dural Arteriovenous Fistulas in the Covid-19 era: a warning and rationale for association

“…vaccine, Janssen) 8, 20,21 . Later, other reports also described this syndrome in patients receiving mRNA-based vaccines (BNT162b2, P zer-BioNTech) 10 . VITT is characterized by mild to severe thrombocytopenia, a low to normal range of brinogen, elevated D-dimer and normal or mildly increased coagulation times 22 .…”

“…In addition, immunemediated vaccine-induced thrombotic thrombocytopenia (VITT) has been recently related to vaccination against COVID-19 8,9 . This rare side effect was fundamentally associated with adenovirus vector-based vaccines; later on, a weaker association with mRNA-based vaccines was also suggested 10 .…”