Case series of ultrasound-guided platelet-rich plasma injections for sacroiliac joint dysfunction

Ko, Gordon; Mindra, Sean; Lawson, Gordon E.; Whitmore, Scott; Arseneau, Leigh

doi:10.3233/bmr-160734

Cited by 45 publications

(21 citation statements)

References 43 publications

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“…Modified ODI and SF‐12 scores gradually improved in the PRP group through 3 months, while the steroid group demonstrated initial improvement at 4 weeks with subsequent deterioration at 3 months . Additionally, there were two level IV studies that demonstrated significant pain reduction at 1 year, with one study demonstrating sustained clinical benefits through 4 years . Noteworthy, Ko et al injected PRP at Hackett points A, B, and C (posterior SI ligaments).…”

Section: Orthobiologics and The Literaturementioning

confidence: 99%

“…Although their target was not truly intra‐articular SIJs, the decision was made to include this study within the review because of the proximity of the posterior SI ligaments to the actual SIJ and the likelihood, given the high number of injections utilized, that some PRP was actually injected within the SIJ. This should be taken into account when interpreting their results …”

Section: Orthobiologics and The Literaturementioning

confidence: 99%

“…70 Additionally, there were two level IV studies that demonstrated significant pain reduction at 1 year, with one study demonstrating sustained clinical benefits through 4 years. 71,72 Noteworthy, Ko et al injected PRP at Hackett points A, B, and C (posterior SI ligaments). Although their target was not truly intra-articular SIJs, the decision was made to include this study within the review because of the proximity of the posterior SI ligaments to the actual SIJ and the likelihood, given the high number of injections utilized, that some PRP was actually injected within the SIJ.…”

Section: Sacroiliac Joint Orthobiologic Studiesmentioning

confidence: 99%

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Regenerative Medicine for Axial and Radicular Spine‐Related Pain: A Narrative Review

et al. 2020

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Introduction Regenerative injection‐based therapy has established itself as a therapeutic option for the management of a variety of painful musculoskeletal conditions. The aim of this work was to review the current literature regarding regenerative injection therapy for axial/radicular spine pain. Methods A comprehensive literature review was conducted on the use of regenerative medicine for axial/radicular spine pain. Eligible articles analyzed the therapeutic injection effects of platelet‐rich plasma (PRP), prolotherapy, or mesenchymal signaling cells (MSCs) via intradiscal, facet joint, epidural, or sacroiliac joint delivery. Results Regarding intradiscal PRP, there are level I/IV studies supporting its use. Regarding intradiscal prolotherapy, there are level III to IV studies supporting its use. Regarding intradiscal MSCs, there are level I/IV studies supporting its use with the exception of one level IV study that found no significant improvement at 12 months. Regarding facet joint injections with PRP, there are level I/IV studies supporting its use. Regarding facet joint injections with prolotherapy, there are level IV studies supporting its use, though the one level I study did not demonstrate any statistical significance supporting its use. Regarding epidural injections with PRP, there are level I/IV studies supporting its use. Regarding epidural injections with prolotherapy, there are level IV studies supporting its use, though the one level I study did not demonstrate statistical significance beyond 48 hours. Regarding sacroiliac joint injections with PRP, there are level I/IV studies supporting its use. Regarding sacroiliac joint injections with prolotherapy, there are level I/III studies supporting its use. Conclusions Currently, there are level I studies to support the use of PRP and MSC injections for discogenic pain; facet joint injections with PRP; epidural injections of autologous conditioned serum and epidural prolotherapy; and PRP and prolotherapy for sacroiliac joint pain. One level I study showed that facet joint prolotherapy has no significant benefit. Notably, no intervention has multiple published level I studies.

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Section: Orthobiologics and The Literaturementioning

confidence: 99%

Section: Orthobiologics and The Literaturementioning

confidence: 99%

Section: Sacroiliac Joint Orthobiologic Studiesmentioning

confidence: 99%

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Regenerative Medicine for Axial and Radicular Spine‐Related Pain: A Narrative Review

et al. 2020

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“…Given a relative paucity of strong clinical outcome literature, use of prolotherapy remains investigational. Other novel agents that are being evaluated with regard to SIJ injection include platelet rich plasma and additional regenerative agents …”

Section: Summary Of the Published Literaturementioning

confidence: 99%

“…Other novel agents that are being evaluated with regard to SIJ injection include platelet rich plasma and additional regenerative agents. 38…”

Section: Clinical Outcomes Of Therapeutic Injectionsmentioning

confidence: 99%

Image‐Guided Sacroiliac Joint Injections: an Evidence‐based Review of Best Practices and Clinical Outcomes

Zheng

Schneider

Yang

et al. 2019

PM&R

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Injections into the intraarticular sacroiliac joint (SIJ) are commonly done for both diagnostic and therapeutic reasons. Injection of an anesthetic can aid in the diagnosis of SIJ pain. Corticosteroids can be administered with the goal of providing a therapeutic effect. This article summarizes the literature regarding the diagnostic and therapeutic effects of these injections. It includes a review of the various imaging modalities including fluoroscopy, ultrasound, and computed tomography guidance, as well as a discussion on the prevalence data and other variables that may affect the reported outcomes.

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Regenerative Medicine

Snitzer¹,

Patel²,

Zheng³

et al. 2019

Academic Pain Medicine

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Case series of ultrasound-guided platelet-rich plasma injections for sacroiliac joint dysfunction

Abstract: Platelet-rich plasma therapy exhibits clinical usefulness in both pain reduction and for functional improvement in patients with chronic SI joint pain. The improvement in joint stability and low back pain was maintained at 1- and 4-years post-treatment.

Cited by 45 publications

References 43 publications

Regenerative Medicine for Axial and Radicular Spine‐Related Pain: A Narrative Review

Regenerative Medicine for Axial and Radicular Spine‐Related Pain: A Narrative Review

Image‐Guided Sacroiliac Joint Injections: an Evidence‐based Review of Best Practices and Clinical Outcomes

Regenerative Medicine

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