Case studies in anticoagulation management

Traditional Anticoagulants and Hair Loss: A Role for Direct Oral Anticoagulants? A Review of the Literature

“…Both of them complained of increased hair shedding 2 months into treatment [ 15 ]. In recent years there have been only two reports of warfarin-associated alopecia: In 2008 a 70-year-old female anticoagulated for deep vein thrombosis (7 mg/day, no international normalized ratio (INR) target reported) was described to lose patches of previously thick hair soon after commencing treatment [ 16 ]. Nakamizo and colleagues [ 17 ] describe a 25-year-old man who underwent several cycles of chemotherapy and as a result lost hair all over his body, which then fully regrew 5 months after finishing treatment.…”

Alopecia em pacientes anticoagulados

“…Other complications of lesser severity, such as alopecia, are little investigated or even ignored during anticoagulant therapy, even those that are common complaints among patients. [8][9][10] Anticoagulants act on the anagen phase of hair growth, stimulating the follicle to prematurely enter the telogen phase, generally leading to visible alopecia around 2 to 4 months after administration is initiated. 2,5,7,8 One hypothesis is that anticoagulant-induced alopecia might be caused by disseminated thrombosis in the microcirculation of capillaries that feed the roots of the hair, but this has not been proven scientifically.…”

“…5,6,8,9 The occurrence of alopecia clinically associated with warfarin is common and is more frequent among female patients, with overall reported incidence from 30 to 40%. 1,2,7,9,10 Characteristics such as older patient age, longer duration of treatment or higher dosage are risk factors associated with the condition and the majority of reports reveal that alopecia is reversed when treatment is withdrawn. 5,[11][12][13][14]…”

Introductory Chapter: Anticoagulant Therapy in Clinical Practice - Challenges and Wishes

“…The clinical practice involving the use of anticoagulants, e.g., dosing, timing, and managing complications, has been a real challenge even to some of the best experts in the field mainly due to their potential to cause serious adverse effects, both hemorrhagic and nonhemorrhagic which may occur with all the currently used anticoagulants regardless of their year of discovery [2,[5][6][7][8].…”