Case Study: Corticosteroid Treatment of Language Regression in Pervasive Developmental Disorder

Stefanatos, Gerry A.; Grover, Warren D.; Geller, E. Scoot

doi:10.1097/00004583-199508000-00022

Cited by 89 publications

(47 citation statements)

References 16 publications

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“…131,132 Another study describes the use of steroids in an autistic child with auditory verbal agnosia and regression, but with normal EEG findings. 133 In the literature, there are many abstracts and case reports about the use of valproic acid and steroids in children with AER, but controlled studies are still necessary. A small number of studies in children with autistic regression and epilepsy (clinical history of seizures) has suggested the possible use of epilepsy surgery techniques with positive results.…”

Section: Pharmacotherapymentioning

confidence: 99%

Autismo e doenças invasivas de desenvolvimento

Gadia¹,

Tuchman²,

Rotta³

2004

J. Pediatr. (Rio J.)

121

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Objective: To review the current knowledge on neurobiological aspects of autism and pervasive developmental disorders, as well as to provide pediatricians with up to date information on diagnosis and treatment of autism. Sources of data: Review of MEDLINE and Internet.Summary of the findings: Autism is the 3rd developmental disorder, with an incidence of 40 to 130/100,000 individuals. Diagnosis is based on clinical findings, following DSM IV criteria. Neuroimaging, investigation of fetal neurological status, and genetic investigation contribute towards a better understanding of the neurobiology of autism. Conclusion:Pediatricians are the first health professional to come in contact with patients with autism. Thus, they should be able to diagnose and to coordinate the multidisciplinary treatment of these patients.J Pediatr (Rio J). 2004;80(2 Suppl):S83-S94: Autism, child behavior, child development.

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Section: Pharmacotherapymentioning

confidence: 99%

Autismo e doenças invasivas de desenvolvimento

Gadia¹,

Tuchman²,

Rotta³

2004

J. Pediatr. (Rio J.)

121

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“…Other steroid treatment series of regressed language in autistic spectrum patients diagnosed with LKS variant showed improved language with pulse-dose steroids. 73,76,77 A single case report documenting language and social improvement after daily high-dose steroids in a regressive case of autism with normal EEG findings was based on abnormal cortical response to frequency-modulated, auditory-evoked potentials based on work from Stefanatos et al 78 This patient had a robust steroid response to prednisone. There has not been any follow-up or similar use of this technique to document steroid response, and although long-term outcome did show improved language and social function, the autism diagnosis remained.…”

Section: Corticosteroidsmentioning

confidence: 99%

Immune Therapy in Autism: Historical Experience and Future Directions with Immunomodulatory Therapy

Chez

Guido-Estrada

2010

Neurotherapeutics

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Summary: Autism affects 1 in 110 new births, and it has no single etiology with uniform agreement. This has a significant impact on the quality of life for individuals who have been diagnosed with autism. Although autism has a spectrum quality with a shared diagnosis, it presents a uniquely different clinical appearance in each individual. Recent research of suspected immunological factors have provided more support for a probable immunological process or for processes that may play a role in the acquisition of an autistic condition. These factors include prenatal, genetic, and postnatal findings, as well as the discovery of a dysfunctional chronic pro-inflammatory state in brain tissue and cerebrospinal fluid in subsets of autistic patients. These findings offer new theories that may lead to the development of disease modification or preventative therapeutic options in the near future. This article reviews prenatal, genetic, and observed immune aspects of the autism condition that may be risk factors in the presentation of the autistic clinical phenotype. Historical immune interventions in autism are reviewed and potential new therapies and interventions are discussed.

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“…Некоторые противосудорожные препараты могут усиливать эпилептиформную актив-ность, утяжелять эпилептические припадки и эпилепти-ческие энцефалопатии. К ним относятся карбамазепин, фенобарбитал, фенитоин, а из новейших препаратов -вигабатрин и окскарбазепин [4,38,[48][49][50]. Препаратами, в отношении которых доказано свойство эффективно по-давлять эпилептиформную активность в ЭЭГ и, следова-тельно, эффективными в отношении эпилептических эн-цефалопатий, являются вальпроевая кислота (депакин), ламотриджин (ламиктал) и леветирацетам (кеппра).…”

Section: речевая область верникеunclassified

“…Используют как натуральный АКТГ и его синтетический аналог Синактен депо, так и преднизолон. Дозировки препарата широко варьируют, поскольку индивидуальные пациенты отвечают на разные режимы лечения [2,48].…”

Section: речевая область верникеunclassified

Neuropathology of epileptic encephalopathies and non-paroxysmal epileptic disorders and principles of their treatment

Зенков

2010

Neurology, Neuropsychiatry, Psychosomatics

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Case Study: Corticosteroid Treatment of Language Regression in Pervasive Developmental Disorder

Cited by 89 publications

References 16 publications

Autismo e doenças invasivas de desenvolvimento

Autismo e doenças invasivas de desenvolvimento

Immune Therapy in Autism: Historical Experience and Future Directions with Immunomodulatory Therapy

Neuropathology of epileptic encephalopathies and non-paroxysmal epileptic disorders and principles of their treatment

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