Case Study of Hypertriglyceridemia from COVID-19 Pfizer-BioNTech Vaccination in a Patient with Familial Hypercholesteremia

Cheung, Brian; Hwang, Jay; Stolarczyk, Ania; Mahlof, Elliot; Block, Robert C.

doi:10.1016/j.jacl.2021.09.019

Cited by 4 publications

(6 citation statements)

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“…Patients included after inclusion/exclusion criteria did not present active SARS-CoV-2 infection and were not vaccinated in the days before admission for acute pancreatitis. Some authors have reported acute pancreatitis and HTG after COVID-19 vaccination [ 58 , 59 ].…”

Section: Discussionmentioning

confidence: 99%

The role of high serum triglyceride levels on pancreatic necrosis development and related complications

et al. 2023

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Background The relevance of elevated serum triglyceride (TG) levels in the early stages of acute pancreatitis (AP) not induced by hypertriglyceridemia (HTG) remains unclear. Our study aims to determine the role of elevated serum TG levels at admission in developing pancreatic necrosis. Methods We analyzed the clinical data collected prospectively from patients with AP. According to TG levels measured in the first 24 h after admission, we stratified patients into four groups: Normal TG (< 150 mg/dL), Borderline-high TG (150–199 mg/dL), High TG (200–499 mg/dL) and Very high TG (≥ 500 mg/dL). We analyzed the association of TG levels and other risk factors with the development of pancreatic necrosis. Results A total of 211 patients were included. In the Normal TG group: 122, in Borderline-high TG group: 38, in High TG group: 44, and in Very high TG group: 7. Pancreatic necrosis developed in 29.5% of the patients in the Normal TG group, 26.3% in the Borderline-high TG group, 52.3% in the High TG group, and 85.7% in the Very high TG group. The trend analysis observed a significant association between higher TG levels and pancreatic necrosis (p = 0.001). A multivariable analysis using logistic regression showed that elevated TG levels ≥ 200 mg/dL (High TG and Very high TG groups) were independently associated with pancreatic necrosis (OR: 3.27, 95% CI − 6.27, p < 0.001). Conclusions An elevated TG level at admission ≥ 200 mg/dl is independently associated with the development of pancreatic necrosis. The incidence of pancreatic necrosis increases proportionally with the severity of HTG.

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Section: Discussionmentioning

confidence: 99%

The role of high serum triglyceride levels on pancreatic necrosis development and related complications

et al. 2023

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“…By binding to an inactivated virus (vaccine) containing the spike protein to pancreatic ACE2 receptors, there is a possibility of pancreatitis [ 28 ]. In other hand, COVID-19 vaccine can cause hypertriglyceridemia [ 45 ] and this secondary hypertriglyceridemia, can lead to pancreatitis.…”

Section: Discussionmentioning

confidence: 99%

Acute pancreatitis following COVID-19 vaccine: A case report and brief literature review

Boskabadi

Ala

Heydari

et al. 2023

Heliyon

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“…This mechanism may underlie some of the adverse effects observed upon the administration of m-RNA vaccines [7] . For instance, it is reported that a 60-year-old man with heterozygous familial hypercholesterolemia (HeFH) and high triglycerides (TG) presented unusually high TG values (1300 mg/dL) one day after receiving his second Pfizer-BioNTech vaccine injection [8] . This suggests that the S protein could affect lipid metabolism in patients with elevated cholesterol and TG levels, and such an effect should be independent of the antibody response to the vaccine.…”

Section: Introductionmentioning

confidence: 99%

High-Density Lipoprotein function is modulated by the SARS-CoV-2 spike protein in a lipid-type dependent manner

Correa

Giudice

Waldie

et al. 2023

Journal of Colloid and Interface Science

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Case Study of Hypertriglyceridemia from COVID-19 Pfizer-BioNTech Vaccination in a Patient with Familial Hypercholesteremia

Cited by 4 publications

References 0 publications

The role of high serum triglyceride levels on pancreatic necrosis development and related complications

The role of high serum triglyceride levels on pancreatic necrosis development and related complications

Acute pancreatitis following COVID-19 vaccine: A case report and brief literature review

High-Density Lipoprotein function is modulated by the SARS-CoV-2 spike protein in a lipid-type dependent manner

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