Case Study of Roadway Deformation Failure Mechanisms: Field Investigation and Numerical Simulation

Li, Guang; Ma, Feifei; Guo, Jie; Zhao, Haijun

doi:10.3390/en14041032

Cited by 22 publications

(11 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Based on the Buckingham π theorem, the ratio of the same quantities in the prototype and model was defined as the similarity constant C. Through comprehensive consideration of the laboratory equipment and boundary conditions, the dimension of the physical model was set as 30 × 30 × 5 cm. Thus, the geometry similarity constant C l was 40, and the other basic physical quantities were characterized in accordance with this ratio ( Table 2 ) [ 43 ].…”

Section: Methodsmentioning

confidence: 99%

Experimental Study of the Damage and Failure Characteristics of the Backfill-Surrounding Rock Contact Zone

Yang

Guo

et al. 2022

Materials

Self Cite

View full text Add to dashboard Cite

Due to obvious differences in the properties of the filling body and surrounding rock, deformation always develops near the contact zone. Thus, determining the damage and failure characteristics of the contact zone between the backfill and surrounding rock is a precondition for safe production in mines. Taking Jinchuan mine as study area, the backfill-surrounding rock contact zones are divided into three models according to their different geometric shapes, namely, a linear model, embedded model, and multiple broken line model. A combined numerical simulation and physical model test method was adopted in this study. The research results show that the damage in the linear model begins at the seam, the failure is mainly concentrated in the filling body, and shear failure is dominant. The damage in the embedded model initially occurs around the inflection points, while the damage in the multiple broken line model initially occurs at the seams, and cracks always appear on the vertical contact surface first. Among the three contact models, the stability increases as follows: embedded > multiple broken line > linear. Moreover, the filling body enclosed by surrounding rock is the most stable, and the surrounding rock located in the footwall is more stable than the filling body located in the footwall. The conclusions of this study provide a theoretical basis for designing a mining scheme for Jinchuan mine and other mines with similar geological conditions and mining methods, and they provide a reference for studying the mechanical properties and stability of composite materials.

show abstract

Section: Methodsmentioning

confidence: 99%

Experimental Study of the Damage and Failure Characteristics of the Backfill-Surrounding Rock Contact Zone

Yang

Guo

et al. 2022

Materials

Self Cite

View full text Add to dashboard Cite

show abstract

“…The wound repair process involves multiple cell types, of which FBs play essential roles since they, alongside with ECs, orchestrate the synthesis of the replacement extracellular matrix (ECM) [ 47 , 105 , 115 , 116 , 117 ]. FBs are the main actors in both the proliferative and remodeling phases of wound healing ( Figure 2 ) [ 27 , 117 ].…”

Section: Autophagy In the Main Cellular Types Involved In Dental Impl...mentioning

confidence: 99%

Autophagy Plays Multiple Roles in the Soft-Tissue Healing and Osseointegration in Dental Implant Surgery—A Narrative Review

et al. 2022

View full text Add to dashboard Cite

Dental endo-osseous implants have become a widely used treatment for replacing missing teeth. Dental implants are placed into a surgically created osteotomy in alveolar bone, the healing of the soft tissue lesion and the osseointegration of the implant being key elements to long-term success. Autophagy is considered the major intracellular degradation system, playing important roles in various cellular processes involved in dental implant integration. The aim of this review is an exploration of autophagy roles in the main cell types involved in the healing and remodeling of soft tissue lesions and implant osseointegration, post-implant surgery. We have focused on the autophagy pathway in macrophages, endothelial cells; osteoclasts, osteoblasts; fibroblasts, myofibroblasts and keratinocytes. In macrophages, autophagy modulates innate and adaptive immune responses playing a key role in osteo-immunity. Autophagy induction in endothelial cells promotes apoptosis resistance, cell survival, and protection against oxidative stress damage. The autophagic machinery is also involved in transporting stromal vesicles containing mineralization-related factors to the extracellular matrix and regulating osteoblasts’ functions. Alveolar bone remodeling is achieved by immune cells differentiation into osteoclasts; autophagy plays an important and active role in this process. Autophagy downregulation in fibroblasts induces apoptosis, leading to better wound healing by improving excessive deposition of extracellular matrix and inhibiting fibrosis progression. Autophagy seems to be a dual actor on the scene of dental implant surgery, imposing further research in order to completely reveal its positive features which may be essential for clinical efficacy.

show abstract

“…A great amount of data concerning the prognostic significance of serum levels of different chemokines, cytokines, and other serum proteins has been generated mostly by analyzing samples from hospitalized patients [ 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 ] who, in most of the cases, received experimental drugs immediately on admission [ 7 , 47 , 55 ].…”

Section: Sars-cov-2 Infection Clinical Course In Hospitalized Patient...mentioning

confidence: 99%

SARS-CoV-2-Infection (COVID-19): Clinical Course, Viral Acute Respiratory Distress Syndrome (ARDS) and Cause(s) of Death

Ramadori

2022

Medical Sciences

View full text Add to dashboard Cite

SARS-CoV-2-infected symptomatic patients often suffer from high fever and loss of appetite which are responsible for the deficit of fluids and of protein intake. Many patients admitted to the emergency room are, therefore, hypovolemic and hypoproteinemic and often suffer from respiratory distress accompanied by ground glass opacities in the CT scan of the lungs. Ischemic damage in the lung capillaries is responsible for the microscopic hallmark, diffuse alveolar damage (DAD) characterized by hyaline membrane formation, fluid invasion of the alveoli, and progressive arrest of blood flow in the pulmonary vessels. The consequences are progressive congestion, increase in lung weight, and progressive hypoxia (progressive severity of ARDS). Sequestration of blood in the lungs worsens hypovolemia and ischemia in different organs. This is most probably responsible for the recruitment of inflammatory cells into the ischemic peripheral tissues, the release of acute-phase mediators, and for the persistence of elevated serum levels of positive acute-phase markers and of hypoalbuminemia. Autopsy studies have been performed mostly in patients who died in the ICU after SARS-CoV-2 infection because of progressive acute respiratory distress syndrome (ARDS). In the death certification charts, after respiratory insufficiency, hypovolemic heart failure should be mentioned as the main cause of death.

show abstract

Case Study of Roadway Deformation Failure Mechanisms: Field Investigation and Numerical Simulation

Cited by 22 publications

References 25 publications

Experimental Study of the Damage and Failure Characteristics of the Backfill-Surrounding Rock Contact Zone

Experimental Study of the Damage and Failure Characteristics of the Backfill-Surrounding Rock Contact Zone

Autophagy Plays Multiple Roles in the Soft-Tissue Healing and Osseointegration in Dental Implant Surgery—A Narrative Review

SARS-CoV-2-Infection (COVID-19): Clinical Course, Viral Acute Respiratory Distress Syndrome (ARDS) and Cause(s) of Death

Contact Info

Product

Resources

About