The greenhouse foundation method requires a lower allowable bearing capacity compared to general buildings, but the high-spec and expensive prestressed high-strength concrete (PHC) pile reinforcement method is mainly applied. Therefore, the deep cement mixing (DCM) method, which is one of the ground reinforcement foundations that replaces the PHC piles and secures structural safety suitable for the greenhouse foundation, was considered. To verify the structural safety of the DCM method, a geotechnical survey and soil test were conducted, and a long-term settlement monitoring system was established. The specifications of the DCM foundation were designed to be 0.8 m in diameter, 3 m × 3 m in width and length, and 3 m in depth. Based on the settlement monitoring data, long-term settlement was predicted considering the greenhouse durability of 15 years. For long-term settlement prediction, the Log S–T, hyperbolic, Asaoka method, Schmertmann theory, and the finite element method (FEM) analysis were performed. In the case of the Log S–T, hyperbolic, and Asaoka method based on actual measurement data, the settlement amount was predicted to be 12.18~20.43 mm, and in the case of the Schmertmann empirical formula, it was predicted to be 19.66 m. The FEM analysis result was 8.89 mm. As the most conservative result, the DCM foundation method designed in this paper had an allowable bearing capacity of 310 kN/m2 and a long-term settlement of 20.43 mm. This is the result of satisfying both the allowable bearing capacity of 100 kN/m2 and the allowable settlement range of 25.4 mm as a foundation. Through this study, it was proven that long-term structural safety can be sufficiently secured when the DCM foundation is constructed on a soft ground through a design that considers the required service life and allowable bearing capacity of the structure. In addition, it was confirmed that the Hyperbolic, Asaoka, and FEM analysis method adopted in this paper can be applied to the long-term settlement behavior analysis of the DCM foundation method.