Case Study of the Patient Considering Chronic Renal Failure Treated with Bojungikki-tang and Bojungikki-tang gamibang

Nam, Woo-Jin; Bae, Su-Hyun; Park, Sunyoung; Jung, So‐Youn; Park, Dong Il

doi:10.14374/hfs.2013.21.2.181

Cited by 5 publications

(1 citation statement)

References 2 publications

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“…Among these, OR has been reported to prevent renal injury in diabetes-induced renal dysfunction, nephrosis, and hyperuricemic models [ 20 – 22 ], and systems pharmacology has revealed that its mechanisms of action involve the renin-angiotensin-aldosterone system (RAAS) for treating hypertension [ 23 ]. Case reports for treatments with BJ have shown improved symptoms in patients with chronic renal failure [ 24 , 25 ]. However, there have been few studies on treatments of BJ, PJ, or WR for AKI, to the best of our knowledge.…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Traditional Herbal Formulas on Cisplatin‐Induced Nephrotoxicity in Renal Epithelial Cells via Antioxidant and Antiapoptotic Properties

Dachuri

Song

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Acute kidney injury (AKI) is characterized by a rapid loss of renal function. Drug-induced AKI accounts for up to 60% of all cases, resulting in a severe threat particularly to hospitalized patients, but there are no effective treatments. Four polyherbal formulas, Bojungikki-tang (BJ), Palmijihwang-tang (PJ), Oryeong-san (OR), and Wiryeong-tang (WR), have long been used for treatments of symptoms of kidney disease in traditional Korean medicine. Even though they are commercially available, evidences supporting the efficacy on AKI are still lacking. Therefore, the effectiveness of polyherbs on AKI and the underlying mechanisms were examined. Renal cell damage was induced by cisplatin at 20 μM and 16 μM in proximal tubular epithelial cell lines of rat NRK-52E and human HK-2, respectively. The cells were treated with the polyherbal formals for 3 days, and the cell viability, antioxidant activities, and apoptosis were examined. In addition, the proliferative effects were assessed under serum-free conditions. The results were compared with those of the vehicle-treated cells as a control. Three polyherbs BJ, PJ, and WR but not OR showed strong free radical scavenging activities in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. The treatments of BJ, PJ, OR, and WR significantly increased the cell viabilities under cisplatin-induced nephrotoxicity. Consistent with the results of the DPPH assay, superoxide dismutase and catalase activities were increased in the cisplatin-induced cell model treated with BJ, PJ, and WR but not with OR. However, annexin-V-positive cells and cleaved caspase 3 expression were significantly reduced in the cell model treated with all of the polyherbs. Cell proliferation was observed in treatment with all of the polyherbs, which was particularly evident in the OR-treated cells. This provides effective complementary evidences to promote the development of traditional herbal formulas to treat AKI.

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Section: Introductionmentioning

confidence: 99%

Protective Effects of Traditional Herbal Formulas on Cisplatin‐Induced Nephrotoxicity in Renal Epithelial Cells via Antioxidant and Antiapoptotic Properties

Dachuri

Song

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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A Case Report of Chronic Renal Failure(stage4) on Stroke Patient through Integrative Medicine Therapy.

Hwang¹,

Lee²,

Kim³

2016

Herbal Formula Science

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Objective : Chronic renal failure(CRF) is defined as a permanent reduction in glomerular filtration rate(GFR), resulting in Structural and functional abnormalities. The purpose of this thesis is to report the improvement of a CRF stage4 on stroke patient through integrative medicine therapy. Methods :We treated the patient with herbal medication(Sibjeondaebo-tang gagambang), acupuncture and moxibustion as well as Western medication. We measured the Creatinine, BUN, eGFR in the serum and observed clinical symptoms During 4months. Result :After treatment, the level of BUN and Creatinine was decreased and eGFR was increased. And the symptoms of CRF(edema, anorexia, general weakness) were improved. Conclusion :This study suggests that Integrative Medicine Therapy is effective in the treatment of CRF symptoms.In the future, for the effective management of CRF, It is considered necessary to build a systematic integrative medicine therapy.

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A Case Report of Drug-Induced Acute Renal Failure Treated with Herbal Medicine

김¹,

박²,

서³

et al. 2016

J Int Korean Med

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Objective: To report the effects of Siryeng-tang (柴苓湯) and Chijasi-tang (梔子豉湯) on a patient with drug-induced acute renal failure.Methods: A female patient was diagnosed with acute renal failure. The symptoms decreased urine output, tachycardia, dyspnea, and chest discomfort. The patient was treated with Siryeng-tang for one day and Chijasi-tang for about 5 days.Results: After taking Siryeng-tang, urine output increased and the values for blood urea nitrogen and creatinine were decreased to normal. Taking Chijasi-tang improved other related symptoms.Conclusions: Siryeng-tang and Chijasi-tang can improve the symptoms of acute renal failure.

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Case Study of the Patient Considering Chronic Renal Failure Treated with Bojungikki-tang and Bojungikki-tang gamibang

Cited by 5 publications

References 2 publications

Protective Effects of Traditional Herbal Formulas on Cisplatin‐Induced Nephrotoxicity in Renal Epithelial Cells via Antioxidant and Antiapoptotic Properties

Protective Effects of Traditional Herbal Formulas on Cisplatin‐Induced Nephrotoxicity in Renal Epithelial Cells via Antioxidant and Antiapoptotic Properties

A Case Report of Chronic Renal Failure(stage4) on Stroke Patient through Integrative Medicine Therapy.

A Case Report of Drug-Induced Acute Renal Failure Treated with Herbal Medicine

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