Case Study on Beta Blockers Induced Psoriasis

Abstract

Drug-induced Psoriasis is one among the common etiological factors of Psoriasis reported worldwide. Familiar drugs known to cause psoriasiform eruptions include Anti-malarials, Beta blockers, NSAIDs, Lithium. etc. Certain antihypertensives like ACE inhibitors, diuretics are also documented to have caused psoriatic episodes.
 A 57 y old South-Indian male patient with a history of Hypertension, Diabetes Mellitus, Atrial Fibrillation for 4 y; was on antihypertensive therapy for Hypertension and Atrial Fibrillation with proponolol for past 2 y and metoprolol initially. He was presented to the hospital two weeks after switching on to Metoprolol therapy for chief complaints of erythematous scaly lesions especially over both the extremities and paronydrial appearance of nails. Initially, he was on Propranolol therapy which was then shifted to Metoprolol due to an appearance of oral lesions in the mouth. Metoprolol was now discontinued and switched on to Atenolol. After 1-2 w of therapy with Atenolol, the lesions were found to disappear and no recurrence of psoriatic conditions were found.
 Proper reviewing of medical history for any allergic reactions and the optimization of drug therapy through Therapeutic Drug Monitoring could be initiated by Clinical Pharmacist in order to avoid such drug-induced flares.

Evaluation of Antiproliferative Activity of Siddha Anti-Psoriatic Formulation Panchamuga Chendhuram Using Cultured Human Keratinocyte Cell Lines

“…The name is derived from the Greek word psora which means to itch [2]. Psoriasis is defined on a clinical basis as chronic, relapsing, remitting papulosquamous eruption with typical localization on the extensor surfaces such as elbows and knees involving scalp, genitalia or nails, and other sites [3]. Among the psoriasis patients, the ratio of male to female was 1.1:1.…”

Invitro Anticancer Activity of Ethyl Acetate extract of Trichopus zeylanicus. Ssp. Travancoricus Gaertn on Human Cervical Cancer Cell Line HeLa

“…Though the therapeutic property of this plant was known to the Kani tribe of Kerala inhabiting in the Agasthya hills of the Western Ghats, its medicinal properties were never known to the outside world until Pushpangadan et al revealed about it in 1988 [5]. Further scientific investigations reported the plant as an adaptogenic [5], antimicrobial [6], antioxidant [7], anti-fatigue [5], immune enhancing, cardioprotective [8], antidiabetic [9], hepatoprotective [10], anti-nociceptive [11] and anti-inflammatory herb. Being an important ethnomedicinal herb, so far, no study has been carried out on anticancer analysis of leaves of T. zeylanicus.…”

α‐bisabolol β‐d‐fucopyranoside (ABFP) ameliorates scopolamine‐induced memory deficits through cholinesterase inhibition and attenuation of oxidative stress in zebrafish (Danio rerio)

“…Various secondary metabolites including phenolic compounds, flavonoids, and terpenoids are being explored as anti-AD agents. [14] Curcumin, a natural polyphenol extracted from Curcuma longa (Zingiberaceae), acts as an antioxidant, anti-neuroinflammatory, and anti-aggregative agent in the treatment of AD. [15][16][17][18][19][20] Similarly, α-bisabolol is a naturally occurring sesquiterpene isolated from the blossoms of chamomile (Matricaria chamomilla; Asteraceae) by Isaac and collaborators in 1951 [21] possesses diverse ethnomedicinal properties, such as antimicrobial, antioxidant, anti-inflammatory, anticancer, and anti-cholinesterase properties.…”