Abstract:In this study, the relationship between the QBO (quasi-biennial oscillation), which is seen at the equatorial stratosphere, and critical frequency of layer (Es) sporadically observed at the ionospheric E region was analyzed by using multiple regression model. For this analysis, Es layer critical frequency (foEs) obtained from four different stations at equatorial region and QBO measured at 10 hPa altitude values were used. The positive relationship between foEs and QBO was observed at all stations. An increase of 1 m/s at QBO leads to an increase of 0.01 Mhz, 0.02 Mhz, 0.02 Mhz and 0.01 Mhz (Jicamarca, Ascension, Manila and Kwajalein) on foEs, respectively. Expect for Manila station, westerly phase of QBO has greater effect on foEs compared to easterly phase of QBO at all other stations. It is seen that the changes occurred on foEs can be explained by the QBO at rates 47%, 46%, 32% and 44% for Jicamarca, Ascension, Manila and Kwajalein stations, respectively.