Case study on the impact of the source of metabolism parameters in next generation physiologically based pharmacokinetic models: Implications for occupational exposures to trimethylbenzenes

Co-PBK: a computational biomonitoring tool for assessing chronic internal exposure to chemicals and metabolites

“…Thus, the development, improvement, and application of computational methods for assessing environmental exposure and predicting the distribution of toxic chemicals in the human body are urgently required. 15,28 Physiologically-based kinetic (PBK) models are mathematical descriptions based on ordinary differential equations, which are used to predict internal exposure dose by considering the physicochemical properties and physiological and biochemical processes of substances in the human body. 15,[29][30][31] Based on the characteristics of toxic chemicals in terms of absorption, distribution, metabolism, and excretion (ADME), PBK models can estimate urinary biomarker concentrations via specic exposure pathways (e.g., oral ingestion, dermal contact, and inhalation).…”