2019
DOI: 10.1073/pnas.1903357116
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Casein kinase 1 family regulates PRR5 and TOC1 in the Arabidopsis circadian clock

Abstract: The circadian clock provides organisms with the ability to adapt to daily and seasonal cycles. Eukaryotic clocks mostly rely on lineage-specific transcriptional-translational feedback loops (TTFLs). Posttranslational modifications are also crucial for clock functions in fungi and animals, but the posttranslational modifications that affect the plant clock are less understood. Here, using chemical biology strategies, we show that the Arabidopsis CASEIN KINASE 1 LIKE (CKL) family is involved in posttranslational… Show more

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Cited by 79 publications
(152 citation statements)
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“…IC261 and PF‐670462 were purchased (Sigma‐Aldrich catalog numbers I0658 and SML0795, respectively). PHA767491 was synthesized as previously described (Uehara et al, ). All chemical compounds were dissolved in dimethyl sulfoxide (DMSO) as 10 mM stock solutions.…”
Section: Methodsmentioning
confidence: 99%
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“…IC261 and PF‐670462 were purchased (Sigma‐Aldrich catalog numbers I0658 and SML0795, respectively). PHA767491 was synthesized as previously described (Uehara et al, ). All chemical compounds were dissolved in dimethyl sulfoxide (DMSO) as 10 mM stock solutions.…”
Section: Methodsmentioning
confidence: 99%
“…Extensive genetic redundancy among multiple members of the CKL subfamily (e.g., the 13 CKLs in Arabidopsis) may make further delineation of the biological processes regulated by the CK1 family challenging because of the difficulty in eliminating kinase function by knocking out or knocking down gene expression of one or combinations of CK1 family genes. To meet this challenge, small molecule inhibitors of CK1 can be employed to determine whether or not CK1 enzymes are involved in a given biological process (Uehara et al, ). The small molecule IC261 has mostly been used for this purpose, and more recent studies used PF‐670462, which is a more potent and specific inhibitor of plant CK1 enzymes (Mizoi et al, ; Uehara et al, ).…”
Section: Introductionmentioning
confidence: 99%
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