Casein kinase CK2 structure and activities in plants

Wang, Guanfeng; Gao, Geling; Yang, Xiangna; Yang, Xiangdong; Ma, Pengda

doi:10.1016/j.jplph.2022.153767

Cited by 9 publications

(8 citation statements)

References 110 publications

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“…To explore the role of Ca 2+ -dependent protein kinases (CDPKs) in the absorption of PFASs in wheat root, Purvalanol B and 4,5,6,7-tetrabromobenzotriazole (TBB) at concentrations of 10 μM were applied as the CDPK inhibitors , TBB mainly prevents the CDPK phosphorylation and promotes its caspase-dependent degradation, while Purvalanol B is an effective ATP-competitive CDPK inhibitor . All the treatments were harvested after 10 h of exposure and performed in triplicate.…”

Section: Methodsmentioning

confidence: 99%

Impact Mechanisms of Humic Acid on the Transmembrane Transport of Per- and Polyfluoroalkyl Substances in Wheat at the Subcellular Level: The Important Role of Slow-Type Anion Channels

Liu

Zhou

Guo

et al. 2023

Environ. Sci. Technol.

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Per-and polyfluoroalkyl substances (PFASs) have potential to accumulate in crops and pose health risks to humans, but it is unclear how the widely present organic matters in soil, such as humic acid (HA), affect their uptake and translocation in plants. In this study, hydroponic experiments were conducted to systematically disclose the impacts of HA on the uptake, translocation, and transmembrane transport at the subcellular level of four PFASs, including perfluorooctane sulfonic acid, perfluorooctanoic acid, perfluorohexane sulfonic acid, and 6:2 chlorinated polyfluoroalkyl ether sulfonate in wheat (Triticum aestivum L.). The results of the uptake and depuration experiments indicated that HA depressed the adsorption and absorption of PFASs in wheat roots by reducing the bioavailability of PFASs, and HA did not affect the long-range transport of PFASs to be eliminated via the phloem of wheat. However, HA facilitated their transmembrane transport in wheat roots, while the contrary effect was observed in the shoots. The inhibitor experiments coupled with transcriptomics analysis uncover that the increased transmembrane transport of PFASs stimulated by HA is mainly driven by the slow-type anion channel pathways interacting with Ca 2+ -dependent protein kinases (Ca 2+ -CDPK-SLAC1). The promoted transmembrane transport of PFASs might cause adverse effects on the plant cell wall, which causes further concerns.

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Section: Methodsmentioning

confidence: 99%

Impact Mechanisms of Humic Acid on the Transmembrane Transport of Per- and Polyfluoroalkyl Substances in Wheat at the Subcellular Level: The Important Role of Slow-Type Anion Channels

Liu

Zhou

Guo

et al. 2023

Environ. Sci. Technol.

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“…CK2 proteins are involved in many biological processes, including abiotic stress response. Downstream genes were reported (for review; [ 51 ]). Lastly, OsTBP2 is linked to LOC_Os06g48030 , encoding a peroxidase precursor, suggesting that OsTBP2 may also regulate the detoxification enzyme to scavenge reactive oxygen species (ROS) occurring under salt stress [ 52 , 53 ].…”

Section: Resultsmentioning

confidence: 99%

Identification of Salt-Sensitive and Salt-Tolerant Genes through Weighted Gene Co-Expression Networks across Multiple Datasets: A Centralization and Differential Correlation Analysis

Sonsungsan,

Suratanee,

Buaboocha

et al. 2024

Genes

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Salt stress is a significant challenge that severely hampers rice growth, resulting in decreased yield and productivity. Over the years, researchers have identified biomarkers associated with salt stress to enhance rice tolerance. However, the understanding of the mechanism underlying salt tolerance in rice remains incomplete due to the involvement of multiple genes. Given the vast amount of genomics and transcriptomics data available today, it is crucial to integrate diverse datasets to identify key genes that play essential roles during salt stress in rice. In this study, we propose an integration of multiple datasets to identify potential key transcription factors. This involves utilizing network analysis based on weighted co-expression networks, focusing on gene-centric measurement and differential co-expression relationships among genes. Consequently, our analysis reveals 86 genes located in markers from previous meta-QTL analysis. Moreover, six transcription factors, namely LOC_Os03g45410 (OsTBP2), LOC_Os07g42400 (OsGATA23), LOC_Os01g13030 (OsIAA3), LOC_Os05g34050 (OsbZIP39), LOC_Os09g29930 (OsBIM1), and LOC_Os10g10990 (transcription initiation factor IIF), exhibited significantly altered co-expression relationships between salt-sensitive and salt-tolerant rice networks. These identified genes hold potential as crucial references for further investigation into the functions of salt stress response in rice plants and could be utilized in the development of salt-resistant rice cultivars. Overall, our findings shed light on the complex genetic regulation underlying salt tolerance in rice and contribute to the broader understanding of rice’s response to salt stress.

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“…Second, the mutant proteins accumulated to a lesser extent than the WT counterpart, suggesting that phosphorylation of these residues may play a role in maintaining the stability of AtURI. It is tempting to speculate that CK2, a Ser/Thr kinase conserved in eukaryotes with high and constitutive activity [52], is one of the kinases that help maintain AtURI phosphorylated and stable, as several in vivo phosphorylated Ser/Thr on AtURI have been reliably predicted as target sites of CK2 (Table S5). It has been proposed that the interaction with partners can stabilize disordered proteins [43].…”

Section: Resultsmentioning

confidence: 99%

The prefoldin-like protein AtURI exhibits characteristics of instrinsically disordered proteins

Gómez-Mínguez,

Palacios-Abella,

Costigliolo-Rojas

et al. 2023

Preprint

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The prefoldin-like protein UNCONVENTIONAL PREFOLDIN RPB5 INTERACTOR (URI) participates in diverse cellular functions, including protein homeostasis, transcription, translation, and signal transduction. Thus, URI is a highly versatile protein, although the molecular basis of this versatility remains unknown. In this work, we show thatArabidopsis thaliana(Arabidopsis) URI (AtURI) possesses a large intrinsically disordered region (IDR) spanning most of the C-terminal part of the protein, a feature conserved in yeast and human orthologs. Our findings reveal two key characteristics of disordered proteins in AtURI: promiscuity in interacting with partners and protein instability. We propose that these two features contribute to providing AtURI with functional versatility.

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Casein kinase CK2 structure and activities in plants

Cited by 9 publications

References 110 publications

Impact Mechanisms of Humic Acid on the Transmembrane Transport of Per- and Polyfluoroalkyl Substances in Wheat at the Subcellular Level: The Important Role of Slow-Type Anion Channels

Impact Mechanisms of Humic Acid on the Transmembrane Transport of Per- and Polyfluoroalkyl Substances in Wheat at the Subcellular Level: The Important Role of Slow-Type Anion Channels

Identification of Salt-Sensitive and Salt-Tolerant Genes through Weighted Gene Co-Expression Networks across Multiple Datasets: A Centralization and Differential Correlation Analysis

The prefoldin-like protein AtURI exhibits characteristics of instrinsically disordered proteins

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