Casein phosphopeptide (CPP) enhances calcium absorption from the ligated segment of rat small intestine.

Sato, Ryuichio; Noguchi, Tadashi; Nishimura, Hiroshi

doi:10.3177/jnsv.32.67

Cited by 241 publications

(148 citation statements)

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“…Food vehicles may influence the physiological effects of the bioactive components, as other constituents within the food matrices can exert synergistic or antagonistic effects. Furthermore, additional bioactive peptides may enhance absorption of Ca and K, which may have independent hypotensive effects (61) . The choice of an appropriate control product is of paramount importance in order to evaluate the effect of the active ingredient.…”

Section: Discussionmentioning

confidence: 99%

“…This suggests that BP lowering was mediated by the opioid receptors. Phosphopeptides of milk proteins may enhance the solubility of different minerals such as Ca, thus improving their absorption in the intestine (61) . Although oral supplementation of Ca has not been shown to decrease hypertension (76) , dietary Ca intake might have a favourable impact on raised BP (77) .…”

Section: Putative Mechanisms Underlying the Impact Of Milk Peptides Omentioning

confidence: 99%

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The impact of milk proteins and peptides on blood pressure and vascular function: a review of evidence from human intervention studies

2013

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CVD are the leading cause of death worldwide. Hypertension, a major controllable risk factor of CVD, is intimately associated with vascular dysfunction, a defect which is also now recognised to be a major, modifiable risk factor for the development of CVD. The purpose of the present review was to critically evaluate the evidence for the effects of milk proteins and their associated peptides on blood pressure (BP) and vascular dysfunction. After a detailed literature search, the number of human trials evaluating the antihypertensive effects of caseinderived peptides (excluding isoleucine-proline-proline and valine-proline-proline) was found to be limited; the studies were preliminary with substantial methodological limitations. Likewise, the data from human trials that examined the effects of whey protein and peptides were also scarce and inconsistent. To date, only one study has conducted a comparative investigation on the relative effects of the two main intact milk proteins on BP and vascular function. While both milk proteins were shown to reduce BP, only whey protein improved measures of arterial stiffness. In contrast, a growing number of human trials have produced evidence to support beneficial effects of both milk proteins and peptides on vascular health. However, comparison of the relative outcomes from these trials is difficult owing to variation in the forms of assessment and measures of vascular function. In conclusion, there is an accumulating body of evidence to support positive effects of milk proteins in improving and/or maintaining cardiovascular health. However, the variable quality of the studies that produced this evidence, and the lack of robust, randomised controlled intervention trials, undermines the formulation of firm conclusions on the potential benefits of milk proteins and peptides on vascular health.

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Section: Discussionmentioning

confidence: 99%

Section: Putative Mechanisms Underlying the Impact Of Milk Peptides Omentioning

confidence: 99%

The impact of milk proteins and peptides on blood pressure and vascular function: a review of evidence from human intervention studies

2013

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“…Le~-CN (1-25) issu de l'hydrolyse trypsique de la~-caséine est trouvé physiologiquement dans la lumière intestinale au cours de la digestion (Meisel et Frister, 1989 ;Naito et al, 1972). Il est lui-même partiellement résistant aux enzymes digestives et soluble dans le milieu intestinal (Sato et al, 1986 ;Bouhallab et al, 1991 ;Brommage et al, 1991). Les résidus phosphorylés des caséines fixent le calcium et le maintiennent à l'état soluble dans l'intestin (Sato et al, 1986 ;Yuan et Kitts, 1991) ; ils ont éga-Iement la capacité de fixer d'autres cations divalents à la place du calcium, proportionnellement à leur degré de phosphorylation et en fonction du cation (Demott et Dincer, 1976 ;Brulé et Fauquant, 1982 ;West, 1986 ;Causeret, 1986 ;Bouhallab et al, 1991).…”

Section: Introductionunclassified

“…Il est lui-même partiellement résistant aux enzymes digestives et soluble dans le milieu intestinal (Sato et al, 1986 ;Bouhallab et al, 1991 ;Brommage et al, 1991). Les résidus phosphorylés des caséines fixent le calcium et le maintiennent à l'état soluble dans l'intestin (Sato et al, 1986 ;Yuan et Kitts, 1991) ; ils ont éga-Iement la capacité de fixer d'autres cations divalents à la place du calcium, proportionnellement à leur degré de phosphorylation et en fonction du cation (Demott et Dincer, 1976 ;Brulé et Fauquant, 1982 ;West, 1986 ;Causeret, 1986 ;Bouhallab et al, 1991). Le~-CN (1-25) possède quatre des cinq phosphosérines de la protéine native: 1 mole peut fixer 4 moles de fer, avec une affinité 100 fois plus forte que pour le calcium (Bouhallab et al, 1991).…”

Section: Introductionunclassified

Absorption digestive du fer lié au caséinophosphopeptide 1-25 de la β-caséine

Pérès¹,

Bouhallab²,

Bureau³

et al. 1997

Lait

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Summary -Digestive absorption of iron bound to the 1-25 caseinophosphopeptide of~-casein. We investigated the digestive absorption of iron using an isolated, perfused rat intestinalloop. Iron bound to the 1-25 caseinophosphopeptide of~-casein (~-CN (1-25» was compared to iron gluconate. Half of the animals were bled to induce an acute iron deficiency, which enhances iron absorption; the protective effect of~-CN (1-25) against the calcium inhibition of iron absorption was tested as weIl. In the control or anemie groups, iron disappearance from digestive lumen was higher in thẽ -CN (1-25) than in the gluconate group. In control animaIs the amount of iron stored was lower iñ -CN (1-25) animaIs than in animaIs perfused with gluconate, while both groups of anemie animaIs also displayed lower enterocyte retenti on than control animaIs. As a result, the net iron absorption was higher in animaIs perfused with~-CN (1-25) than with gluconate, whether the animaIs were iron depleted or not. Addition of calcium to the perfused solution decreased iron absorption, however, this decrease was significantly reduced in~-CN (1-25) groups. The increased solubility of iron bound to~-CN (1-25) could explain these results, in association with enhancement of the mucosal transfer of iron taken up by the enterocyte.Résumé -L'absorption digestive du fer lié au 1-25 caséinophosphopeptide issu de la~-caséine (~-CN [1-25]) a été comparée à celle du gluconate de fer par le modèle d'intestin perfusé isolé, vascularisé de rat, à l'état basal et dans deux conditions connues pour augmenter l'absorption du fer (saignée) ou l'inhiber (présence de calcium). Chez l'animal normal ou après saignée, la disparition du fer de la lumière intestinale du groupe~-CN (1-25) est supérieure à celle du groupe gluconate. Chez l'animal normal, la rétention entérocytaire du fer est plus faible dans le groupe~-CN (1-25) que * Correspondence and reprints 434 lM Peres et al dans le groupe gluconate. Après saignée, elle est semblable dans les deux groupes et est significativement inférieure à celle des animaux normaux. En conséquence, chez les animaux normaux ou anémiques, l'absorption nette est plus élevée dans les groupes~-CN (1-25) que dans les groupes perfusés avec du gluconate. La fixation du fer au~-CN (1-25) limite significativement l'effet inhibiteur du calcium sur son absorption, chez l'animal contrôle et anémique. Ces résultats semblent dus à la protection intraluminale apportée au fer par sa liaison au~-CN (1-25) soluble, associée à une modification du transport entérocytaire du fer capté.fer / absorption digestive / caséinophosphopeptide~-CN

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“…These CN are normally found in the intestinal lumen during digestion [20,21]. They are somewhat resistant to digestive enzymes [4,5,28]. In vivo studies on the influence of CN on mineral absorption have given conflicting results.…”

Section: Introductionmentioning

confidence: 99%

Improvement of zinc intestinal absorption and reduction of zinc/iron interaction using metal bound to the caseinophosphopeptide 1-25 of β-casein

Pérès¹,

Bouhallab²,

Petit³

et al. 1998

Reprod. Nutr. Dev.

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Casein phosphopeptide (CPP) enhances calcium absorption from the ligated segment of rat small intestine.

Cited by 241 publications

References 13 publications

The impact of milk proteins and peptides on blood pressure and vascular function: a review of evidence from human intervention studies

The impact of milk proteins and peptides on blood pressure and vascular function: a review of evidence from human intervention studies

Absorption digestive du fer lié au caséinophosphopeptide 1-25 de la β-caséine

Improvement of zinc intestinal absorption and reduction of zinc/iron interaction using metal bound to the caseinophosphopeptide 1-25 of β-casein

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