Cases of chikungunya virus infection in travellers returning to Spain from Haiti or Dominican Republic, April-June 2014

Requena‐Méndez, Ana; García, Carolina Carrizo; Aldasoro, Elena; Vicente, Julio; Martínez, Miguel J.; Pérez-Molina, José-Antonio; Calvo-Cano, A; Franco, Leticia; Parrón, I.; Molina, Adriana; Ruiz, M; Álvarez, Jaime; Sánchez-Seco, María Paz; Gascón, Jordi

doi:10.2807/1560-7917.es2014.19.28.20853

Cited by 28 publications

(16 citation statements)

References 22 publications

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“…Moreover, all four known DENV genotypes were detected. An increase in imported CHIKV cases was also observed, as already documented in Spain, mainland France, and Northern Italy, along with the first identification of ZIKV imported cases; both findings are attributable to the recent dramatic spread of both CHIKV and ZIKV in previously unaffected areas [27, 42–44]. The continuous expansion of the areas with Arbovirus circulation, together with the dispersion of Aedes mosquitoes spp.…”

Section: Discussionmentioning

confidence: 57%

Imported arboviral infections in Italy, July 2014-October 2015: a National Reference Laboratory report

et al. 2017

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BackgroundImported cases of infections due to Dengue (DENV) and Chikungunya (CHIKV) viruses and, more recently, Zika virus (ZIKV) are commonly reported among travelers returning from endemic regions. In areas where potentially competent vectors are present, the risk of autochthonous transmission of these vector-borne pathogens is relatively high. Laboratory surveillance is crucial to rapidly detect imported cases in order to reduce the risk of transmission. This study describes the laboratory activity performed by the National Reference Laboratory for Arboviruses (NRLA) at the Italian National Institute of Health in the period from July 2014 to October 2015.MethodsSamples from 180 patients visited/hospitalized with a suspected DENV/CHIKV/ZIKV infection were sent to the NRLA from several Italian Hospitals and from Regional Reference Laboratories for Arboviruses, in agreement with the National Plan on human surveillance of vector-borne diseases. Both serological (ELISA IgM test and Plaque Reduction Neutralization Test—PRNT) and molecular assays (Real Time PCR tests, RT-PCR plus nested PCR and sequencing of positive samples) were performed.ResultsDENV infection was the most frequently diagnosed (80 confirmed/probable cases), and all four genotypes were detected. However, an increase in imported CHIKV cases (41 confirmed/probable cases) was observed, along with the detection of the first ZIKV cases (4 confirmed cases), as a consequence of the recent spread of both CHIKV and ZIKV in the Americas.ConclusionsMain diagnostic issues highlighted in our study are sensitivity limitations of molecular tests, and the importance of PRNT to confirm serological results for differential diagnosis of Arboviruses. The continuous evaluation of diagnostic strategy, and the implementation of laboratories networks involved in surveillance activities is essential to ensure correct diagnosis, and to improve the preparedness for a rapid and proper identification of viral threats.

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Section: Discussionmentioning

confidence: 57%

Imported arboviral infections in Italy, July 2014-October 2015: a National Reference Laboratory report

et al. 2017

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“…As of February 27, 2015, almost 964,341 probable and confirmed cases have been reported in the Caribbean and the rest of the Americas, including 183 deaths . During the past year, several European countries (France, Greece, Italy, the Netherlands, Spain, and Switzerland) have reported imported cases of CHIKV infection in patients with a travel history to the affected areas ; on October 2014, 11 locally acquired infections were reported from the Montpellier area in France . As of May 31, 2014, 10 imported chikungunya cases were reported in Italy, 8 of which were returning travelers from the Caribbean .…”

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confidence: 99%

Chikungunya infection in a human immunodeficiency virus‐infected kidney transplant recipient returning to Italy from the Dominican Republic

Gasperina

Balsamo

Garavaglia

et al. 2015

Transplant Infectious Dis

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Since December 2013, chikungunya virus (CHIKV) spread in many countries of the Western Hemisphere, and during the last year some cases of infected European travelers, coming back from the Caribbean, have been reported. The risk of acquiring severe travel-related illness is higher in immunocompromised subjects, such as patients with human immunodeficiency virus (HIV) infection or solid organ transplant recipients. We reported the first case, to our knowledge, of CHIKV infection in an HIV-infected kidney transplant recipient.

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“…Indeed, some authors have suggested that emerging arboviral diseases probably have a greater potential to spread in tropical or subtropical ecosystems [30]. The increasing number of chikungunya cases ever seen in Spain during the Caribbean outbreak also would reflect this fact and can be argued in support of the hypothesis [31].…”

Section: Discussionmentioning

confidence: 95%

Arboviral infections diagnosed in a European area colonized by Aedes albopictus (2009–2013, Catalonia, Spain)

Valerio

Roure

Fernández‐Rivas

et al. 2015

Travel Medicine and Infectious Disease

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Cases of chikungunya virus infection in travellers returning to Spain from Haiti or Dominican Republic, April-June 2014

Cited by 28 publications

References 22 publications

Imported arboviral infections in Italy, July 2014-October 2015: a National Reference Laboratory report

Imported arboviral infections in Italy, July 2014-October 2015: a National Reference Laboratory report

Chikungunya infection in a human immunodeficiency virus‐infected kidney transplant recipient returning to Italy from the Dominican Republic

Arboviral infections diagnosed in a European area colonized by Aedes albopictus (2009–2013, Catalonia, Spain)

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