Cases of severe methyl bromide poisoning residing above a warehouse.

Ishizu, Sumiko; Kato, Nobuyo; Morinobu, Shigeru; Nagao, Noriki; Yamano, Yuko; Itô, Ichiro

doi:10.1539/joh1959.30.54

Cited by 7 publications

(10 citation statements)

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“…In support of this assumption, when bromide ion analysis 11) was conducted immediately in the biological samples obtained from the patients, all the three patients were found to have plasma bromide ion concentrations about 20 to 30 times higher (Patient I: 72.9 µg/ml, Patient II: 67.8 µg/ml, and Patient III: 91.5 µg/ml) than normal (3.7 ± 1.5 µg/ml) 11) . Moreover, the latency period of at least one day after the exposure (November 14) until the development of symptoms (dawn of November 16) 1,2,9) , and the presence of neurological symptoms, including convulsions [13][14][15][16] , are consistent with the characteristics of methyl bromide poisoning reported to date 1,8,10,17) . Thus, severe acute methyl bromide poisoning was diagnosed.…”

Section: Discussionsupporting

confidence: 80%

“…In mild cases of poisoning, recovery can be expected with symptomatic therapy alone, even if the definitive diagnosis is delayed to some extent. However, oliguria or anuria may develop in serious cases, often associated with proteinuria and hematuria, and death may result 1,8,19) . Therefore, the treatment of renal dysfunction or renal failure associated with the poisoning becomes the most important problem, and institution of dialysis in the early stages has been revealed to be life-saving 5,19,20) .…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, however, the incidence of acute poisoning has decreased as a result of streamlining of the aforementioned processes and improvement of the environment 5) . However, methyl bromide poisoning still occasionally occurs in farmers (and their families) engaged in fumigation and disinfection of soil due, in part, to inappropriate and unsupervised handling of the chemical [6][7][8] . In this paper, we report on three members of a family who developed methyl bromide poisoning, who first experienced symptoms suggestive of food poisoning, including severe vomiting and neurological symptoms such as convulsions.…”

Section: Introductionmentioning

confidence: 99%

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Three Cases of Acute Methyl Bromide Poisoning in a Seedling Farm Family.

et al. 2001

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Abstract:We encountered three patients (Patient I: 39-year-old man, Patient II: 34-year-old woman, and Patient III: 5-year-old girl) with acute methyl bromide poisoning, which had occurred as a result of exposure to the gas that leaked from methyl bromide cans stored in a warehouse of a seedling farm. Since all three patients exhibited almost the same initial symptoms, i.e., severe vomiting, tonic convulsions and clouding of consciousness, botulism was suspected at first. However, subsequent inquiry revealed that 27 cans of methyl bromide had been stored in the building that the patients lived in, and that the cans had been damaged a few days before the onset of the patients' illness by a thrashing machine that was being moved by them to another location. Inspection revealed that all the cans of methyl bromide had passed the expiry date and were corroded. Even though none of the cans had been used, three cans with a capacity of 750 g were found to be empty. Plasma bromide ion concentrations were determined to be high (72.9 µg/ml, 67.8 µg/ml and 91.5 µg/ml; normal level, <5 µg/ml), and acute methyl bromide poisoning was diagnosed 8 days after admission of the patients to the hospital. Hemodialysis (peritoneal lavage in the case of the child) was performed immediately, after which the plasma bromide ion concentrations returned to normal and the general condition of the patients gradually improved.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Three Cases of Acute Methyl Bromide Poisoning in a Seedling Farm Family.

et al. 2001

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“…60 days) 21, 22) So far , the urinary levels of bromine have been used to examine accidental exposures of workers to high concentration of MB . 23,24) In the present study, the urinary bromine concentration and the exhalatory MB concentration were examined as biological exposure indices of workers engaged in fumigation work with MB . The mean concentration of urinary bromine of non-MB workers (6 .…”

Section: Urinary Brominementioning

confidence: 99%

Evaluation of methyl bromide exposure on the plant quarantine fumigators by environmental and biological monitoring.

et al. 1991

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“…In recent years, acute poisoning in these areas has decreased as a result of streamlining and meticulous supervision of these processes, and improvement in the environment". Nevertheless, methyl bromide poisoning still occasionally occurs in farmers engaged in soil fumigation and workers engaged in extermination of termites, in part because the chemical is not handled under adequate supervision7 10) . This is a case report of methyl bromide poisoning in Japanese workers engaged in extermination of termites.…”

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confidence: 99%