Cashew apple fiber prevents high fat diet-induced obesity in mice: an NMR metabolomic evaluation

Carvalho, Diana Valesca; Silva, Lorena; Filho, Elenilson G. Alves; Santos, Flávia Almeida; Lima, Renan Pereira de; Viana, Ana Flávia Seraine Custódio; Nunes, Paulo Iury Gomes; Fonseca, Said Gonçalves da Cruz; Melo, Tiago Sousa de; Viana, Daniel de Araújo; Gallão, Maria Izabel; Brito, Edy Sousa de

doi:10.1039/c8fo01575a

Cited by 36 publications

(22 citation statements)

References 57 publications

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“…As amilases produzem maltose, maltotriose, dextrinas e outros oligossacarídeos que são substratos de oligossacaridases e maltases, resultando em glicose (Murray et al, 1998). O AR e as fibras dietéticas podem reduzir a taxa de digestão e a atividade da enzima amilase prevenindo o aumento do nível de glicose, insulina e diminuindo a glicose plasmática pós-refeição (Carvalho et al, 2019). Como a maioria dos processos de síntese é induzida pela insulina, as diferenças no peso podem estar relacionadas às diferenças na insulinemia dos diferentes grupos (Petersen & Shulman, 2018).…”

Section: Resultsunclassified

Alterações induzidas pela dieta com diferentes concentrações de amido resistente no metabolismo de carboidratos e de lipídeos, em ratos Wistar

Alves

Pigoso

Chang

et al. 2021

RSD

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Este trabalho teve como objetivo avaliar o efeito da substituição do amido pré-gelatinizado por amido resistente no metabolismo de lipídeos e de carboidratos em ratos machos Wistar. 20 ratos machos foram divididos em dois grupos, um grupo recebeu uma dieta com 9,5% (DAP) e o outro grupo com 18,1% (DAR) de amido resistente durante 22 dias. Foram analisados peso, consumo de ração e água, e quantificadas as concentrações de colesterol e de triglicerídeos no soro e no músculo, e de glicogênio hepático e muscular. Os dados foram analisados por teste de Tukey (p>0,05) e gráficos box-plot. Não houve diferenças significativas na ingestão de ração e água, mas os animais do grupo DAP apresentaram aumento de peso (51,12g para 55,27g) enquanto os do grupo DAR diminuíram (49,01g para 44,15g). O grupo DAR apresentou diminuição de triglicérideos, colesterol total no soro (de 125,761 mg/dL para 104,874 mg/dL) e do glicogênio muscular, mas aumento de triglicerídeos no músculo gastrocnêmio em comparação com o grupo DAP (de 0,160 mg/dL para 0,259 mg/dL). Estes resultados apontam para a diminuição na velocidade de absorção da glicose no grupo de animais com dieta com maior quantidade de amido resistente, que pode ter induzido diminuição nos processos de síntese de triglicérideos e de colesterol levando ao aumento do catabolismo destes substratos pelo organismo, e adaptação plástica dos músculos para utilização de ácidos graxos no seu metabolismo oxidativo.

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Section: Resultsunclassified

Alterações induzidas pela dieta com diferentes concentrações de amido resistente no metabolismo de carboidratos e de lipídeos, em ratos Wistar

Alves

Pigoso

Chang

et al. 2021

RSD

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“…CCK can inhibit the activity of hunger‐stimulating neuropeptide Y in the hypothalamus [8]. However, some NDPs can decrease the expression of ghrelin that induces hunger via acting on hypothalamic brain cells in the central nervous system [106]. Fermentable NDPs produce SCFAs that are importantly involved in the regulation and control of appetite and satiety through stimulation of hormonal and neural signals in various organs and tissues [107].…”

Section: Anti‐obesity Via Regulating Appetite and Satietymentioning

confidence: 99%

Behavior of Non‐Digestible Polysaccharides in Gastrointestinal Tract: A Mechanistic Review of its Anti‐Obesity Effect

Zhang

Xie

You

et al. 2021

eFood

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Nowadays, obesity in humans is a huge challenge requiring effective, readily available, and low-risk alternative treatments. Intake of edible Non-Digestible Polysaccharides (NDPs) is regarded as a promising strategy to combat obesity. Herein, an overview of the behavior of NDPs in the Gastrointestinal (GI) tract and its association with anti-obesity effect is summarized. Both the in vitro and in vivo of such investigations are discussed. Results show that NDPs can reach the large intestine to mediate the gut microbiota with the extent of regulation varies among NDPs with different chemical structures. The possible anti-obesity mechanisms associated with behavior of NDPs in the GI tract include: (i) inhibition of fat absorption, (ii) modification of gut microbiota and their metabolites such as short-chain fatty acids, (iii) regulation of bile acid profiles, (iv) modulation on appetite and satiety effect, and (v) protection of intestinal barrier. However, more efforts are required to clarify the exact behavior and their beneficial effects of NDPs within GI tract. This paper will provide an overlook of recent advances for better understanding anti-obesity activity of NDPs.

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“…Various authors have reported the effect of the administration of cashew bagasse in murine models, such as the case of Carvalho et al (2017), who administered 10% of sonicated and lyophilized bagasse to a group of healthy rats, causing an increase in body weight and elevation of serum triglyceride and LDL cholesterol levels after 15 weeks. Later, Carvalho et al (2019) administered natural cashew fiber (IcF) and cashew fiber after undergoing a low molecular weight metabolite (cFSM) extraction process to obese male Swiss mice for 15 weeks. At the end of the treatment, a reduction in glycemia and serum levels of insulin and ghrelin was found, while the animals fed IcF showed hyperlipidemia, hyperleptinemia, and increased abdominal fat, concluding that the elimination of low molecular weight metabolites in cashew bagasse is correlated with the improvement of the health of obese mice.…”

Section: Uses and Applications Of Cashewmentioning

confidence: 99%

Cashew bagasse (Anacardium occidentale L.) as a source of fiberantioxidant and its possible use in lipoinflammation models

HERNÁNDEZ-PÉREZ¹,

RAMÍREZ-HIGUERA²,

CHÁVEZ-REYES³

et al. 2021

CIERMMI Women in Science Biology, Chemistry and Life Sciences Handbook T-Xiv

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Diet has a strong influence on health so that people with good eating habits and moderate exercise decrease the chance of developing diseases. As a result, the consumption of foods containing compounds with a value-added to the per se nutrient value is recommended; these compounds are known as bioactive compounds, such as fiber and antioxidants, which have been related to the decrease of oxidative stress and inflammation present in obesity and that, when not treated, they trigger multiple conditions such as diabetes, hypertension, metabolic syndrome, insulin resistance, and cardiovascular diseases. Cashew (Anacardium occidentale L.) is a fruit from Brazil that serves as a possible source of fiber-antioxidant by containing phenolic compounds and dietary fiber.

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Cashew apple fiber prevents high fat diet-induced obesity in mice: an NMR metabolomic evaluation

Abstract: Dietary fiber intake plays an important role in the prevention of obesity.

Cited by 36 publications

References 57 publications

Alterações induzidas pela dieta com diferentes concentrações de amido resistente no metabolismo de carboidratos e de lipídeos, em ratos Wistar

Alterações induzidas pela dieta com diferentes concentrações de amido resistente no metabolismo de carboidratos e de lipídeos, em ratos Wistar

Behavior of Non‐Digestible Polysaccharides in Gastrointestinal Tract: A Mechanistic Review of its Anti‐Obesity Effect

Cashew bagasse (Anacardium occidentale L.) as a source of fiberantioxidant and its possible use in lipoinflammation models

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