Caso para diagnóstico* (Metástase umbilical de carcinoma pancreático "Sister Mary Joseph Nodule")

Colla, Themis Getsos; Lovatto, Louise; Duquia, Rodrigo Pereira

doi:10.1590/s0365-05962009000300015

Cited by 4 publications

(7 citation statements)

References 3 publications

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“…Cutaneous metastases from PC have been reported in multiple case reports in the literature. [6][7][8][9][10][11] Horino et al reviewed 42 cases of pancreatic metastasis in the literature from 1950 to 2011, with the majority of patients presenting with umbilical cutaneous metastases and presenting predominantly with subcutaneous nodules, 19 consistent with the results from our study. Horino also noted that the incidence of umbilical metastases from cancers of the pancreatic body and tail was significantly more frequent than from the pancreatic head.…”

Section: Discussionsupporting

confidence: 90%

“…4 Our understanding of the pathobiology of PC and cutaneous metastases is primarily based on single case descriptions in the literature. [6][7][8][9][10][11] The most common site of cutaneous metastasis of PC is the umbilicus, also referred to as 'Sister Mary Joseph's nodule'. 12 There is disagreement as to whether these lesions represent cutaneous or deeperseated peritoneal lesions that spread to the umbilicus.…”

Section: Introductionmentioning

confidence: 99%

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Pancreatic cancer: Cutaneous metastases, clinical descriptors and outcomes

Mehta

Rao

et al. 2022

Cancer Medicine

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Background Cutaneous metastases in pancreatic cancer (PC) are rare. Herein, we evaluate the clinical, genomic, and other descriptors of patients with PC and cutaneous metastases. Methods Institutional databases were queried, and clinical history, demographics, PC cutaneous metastasis details, and overall survival (OS) from cutaneous metastasis diagnosis were abstracted. OS was estimated using Kaplan–Meier methods. Results Forty patients were identified, and median age (Q1–Q3, IQR) of PC diagnosis was 66.0 (59.3–72.3, 12.9) years. Most patients had Stage IV disease at diagnosis ( n = 26, 65%). The most common location of the primary tumor was the tail of the pancreas ( n = 17, 43%). The most common cutaneous metastasis site was the abdomen ( n = 31, 78%), with umbilical lesions occurring in 74% ( n = 23) of abdominal lesions. The median OS (95% CI) was 11.4 months (7.0, 20.4). Twenty‐three patients had umbilical metastases (58%), and 17 patients had non‐umbilical metastases (43%). The median OS (95% CI) was 13.7 (7.0, 28.7) months in patients with umbilical metastases and 8.9 (4.1, Not reached) months in patients with non‐umbilical metastases ( p = 0.1). Sixteen of 40 (40%) patients underwent somatic testing, and findings were consistent with known profiles. Germline testing in 12 (30%) patients identified pathogenic variants in patients: CHEK2 , BRCA1, and ATM. Conclusion Cutaneous metastases from PC most frequently arise from a pancreas tail primary site and most frequently occur in the umbilicus. Cutaneous metastases may generally be categorized as umbilical or non‐umbilical metastases.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Pancreatic cancer: Cutaneous metastases, clinical descriptors and outcomes

Mehta

Rao

et al. 2022

Cancer Medicine

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“…In the majority ofcases, the finding of an umbilical nodule represents recurrence or dissemination of known malignancies. Occasionally, however, this may be the initial presentation of the primary disease in up to 30% of the cases [1,8,9].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, in 3-6% of cases it originates from haematological malignancies, or lung and breast cancers. In 15% to 30% of patients the source of the primary site of the tumors remains unknown [1,9,10,11].…”

Section: Discussionmentioning

confidence: 99%

Umbilical metastasis: a report case and review of the literature

Serhrouchni¹,

Fatemi²,

Chbani³

et al. 2013

Pathol Discov

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Sister Mary Joseph's nodule is a metastatic umbilical lesion secondary to a primary malignancy of any viscera. It can be a presenting symptom (a sign of undiagnosed malignancy) or a sign of progression or recurrence in a known case and is usually associated with a poor prognosis. Its incidence is 1%-3% of all intra-abdominal or pelvic malignancies. We report an umbilical metastasis in a case of rectal carcinoma. The clinicopathologic features are discussed, and the related literature is briefly reviewed.

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“…Abdominal wall metastases are described in the literature primarily in postoperative cases. Studies in the past have described cutaneous metastases from pancreatic cancer, citing umbilicus as the most common site for cutaneous metastases [10,11]. In our case, rather than a solid mass, the biopsy was taken from a cystic lesion.…”

Section: Figure 2: Metastatic Sites Of Pancreaticobiliary Cancermentioning

confidence: 97%

Metastatic Pancreatic-Biliary Cancer Presenting as Intramuscular Fluid Collections: A Case Report

Singh

Oliver

Motapothula

et al. 2020

Cureus

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At a certain juncture, when clinicians are unable to gather information about a particular disease especially due to patient's unobtrusive findings, the presence of an aberrant connection might yield a diagnosis. Herein we present the findings of an unusual enlightening case of an 81-year-old Caucasian male with a history of bowel resection, poor appetite, generalized weakness, ptosis, and two weeks of weight loss. The computerized tomography scan revealed several sets of an abdominal intramuscular fluid collection with enhancements in the surrounding, indicative of several abscesses, and brain and spine magnetic resonance imaging indicated right-orbital metastasis in the superior rectal muscles. A biopsy of the cystic lesion of the anterior abdominal wall revealed poorly differentiated metastatic adenocarcinoma, most consistent with the primary pancreaticobiliary origin. This case report sums up this innovative portrayal of metastatic cancer as an intramuscular fluid collection.

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Caso para diagnóstico* (Metástase umbilical de carcinoma pancreático "Sister Mary Joseph Nodule")

Cited by 4 publications

References 3 publications

Pancreatic cancer: Cutaneous metastases, clinical descriptors and outcomes

Pancreatic cancer: Cutaneous metastases, clinical descriptors and outcomes

Umbilical metastasis: a report case and review of the literature

Metastatic Pancreatic-Biliary Cancer Presenting as Intramuscular Fluid Collections: A Case Report

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