Casos de enfermedad de sintomatología neurológica asociados al consumo de anís estrellado empleado como carminativo

Fernández, C Garzo; Pintado, P; Blanco, Alexander; Arrieta, Rosa Martínez; Fernández, Roque B.; Rosa, F. Ramón

doi:10.1016/s1695-4033(02)77929-0

Cited by 21 publications

(12 citation statements)

References 14 publications

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“…In Mexico and the southwestern United States, its fruits are used to make herbal tea to alleviate colic of babies and stomach aches [4,6]. However, in recent years, intoxication cases related to the culinary and medicinal use of star anise have been reported, associating with neurological effects such as seizures, vomiting, jitteriness, rapid eye movement, and even death [7,8,9]. Follow-up investigations indicated that most, if not all, of the adverse effects were caused by adulterated toxic Illicium plants.…”

Section: Introductionmentioning

confidence: 99%

Germacranes and m-Menthane from Illicium lanceolatum

et al. 2014

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Section: Introductionmentioning

confidence: 99%

Germacranes and m-Menthane from Illicium lanceolatum

et al. 2014

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“…The roots and fruits of Illicium lanceolatum have visible central excitatory and peripheral muscarinic effects. An overdose of Illicium lanceolatum first stimulates and then inhibits the human brain and spinal cord, eventually leading to respiratory and circulatory failure, even death [ 26 , 27 ]. This indicates that Illicium lanceolatum could have adverse effects in some conditions.…”

Section: Discussionmentioning

confidence: 99%

Hong-Hui-Xiang Alleviates Pain Hypersensitivity in a Mouse Model of Monoarthritis

Gao

Wang

Yang

et al. 2020

Pain Research and Management

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Background. Hong-Hui-Xiang (HHX) is a sterilized aqueous solution extracted from Illicium lanceolatum A.C. Smith widely used for pain relief in China. Despite its history, it is not well understood. In the present study, we used a mouse model of arthritic knee pain to investigate the antinociceptive effects of HHX and its potential side effects on weight and respiratory function, as well as on the liver, kidney, and heart. Methods. Mice were randomly assigned to four groups: saline and HHX at three doses (1 μl, 10 μl, and 50 μl). Each group was randomly divided to two subgroups: saline and CFA. After the first injection of HHX or saline on day 7, mechanical hyperalgesia was tested via the hind paw. Only after the tests had established that the analgesic effect had subsided was the next injection administered. A total of five injections were administered. Blood, knee joints, and other organs were collected for histopathological observation and biochemical detection. Objectives. We found that mechanical threshold of hind paw increased 2 h after of the initial injection HHX (10 μl and 50 μl), which lasted for at least 3 h. The analgesic effect lasted for three days after the second injection on day 8 and was approximately maintained for five days each time after the third injection. We also found a reduction in the diameter of the knee joint and suppression of synovial inflammation in response to treatment of HHX (10 μl and 50 μl). Meanwhile, HHX had no toxic effects on the liver, kidneys, and heart via histological and biochemical assays in all groups. Conclusion. HHX exerts antinociceptive and anti-inflammatory effects in a mouse model of arthritic knee pain. There were no obvious side effects on the liver, kidneys, or heart.

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“…La evolución clínica en la mayoría de los casos es favorable, en el curso de 24 a 48 horas posteriores a la ingesta, no necesitando otra medida terapéutica más que la observación y de ser necesario el tratamiento sintomático (5,6) .…”

Section: Discussionunclassified

“…Enero -Abril 2005 contienen los frutos enteros, las semillas o el aceite esencial extraído de los frutos (5,6) . El fruto, contiene abundante aceite esencial (5 -8%), constituido en su mayor parte por trans-anetol (80 -90 %), acompañado de aproximadamente un 5% de hidrocarburos monoterpénicos (limoneno, alfa-pineno), prácticamente ausentes en el aceite esencial de anís verde (3) .…”

Section: El Principio Farmacológico Del Anís Estrellado Lounclassified

Intoxicación por anís estrellado (lllicium verum): a propósito de un caso... o de varios casos?

Rojas Galarza,

Porras A.,

Li S.

et al. 2005

Rev Peru Pediatr

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El anis estrellado es empleado en diversos paises para múltiples enfermedades, siendo la más difundida el cólico infantil o del lactante. En los diversos lugares donde se menciona su empleo para tal fin, se han reportado casos de sintomatologia neurológica asociada. La explicación es múltiple y valedera: sobredosificación, contaminación casual o su reemplazo con especies neurotóxicas. Se presenta el caso de sintomatología neurológica asociada a la ingesta de anis estrellado en gemelas. Además, se realiza el planteamiento diagnóstico y diagnóstico diferencial, así como las sugerencias derivadas de la presentación del caso difusión del agente causal, propuestas de investigación, medidas preventivas especificas y generales.

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Casos de enfermedad de sintomatología neurológica asociados al consumo de anís estrellado empleado como carminativo

Cited by 21 publications

References 14 publications

Germacranes and m-Menthane from Illicium lanceolatum

Germacranes and m-Menthane from Illicium lanceolatum

Hong-Hui-Xiang Alleviates Pain Hypersensitivity in a Mouse Model of Monoarthritis

Intoxicación por anís estrellado (lllicium verum): a propósito de un caso... o de varios casos?

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