Casos de infección por gripe pandémica (H1N1) 2009 hospitalizados en cuidados intensivos en España: factores asociados a riesgo de muerte, abril 2009-enero 2010

Peralta, Patricia; García, Marta Cortes; Sánchez, Aurora Limia; Prado, Josefa Andrés; Amo, Isabel Pachón del; Moros, Ma José Sierra

doi:10.1590/s1135-57272010000500008

Cited by 19 publications

(6 citation statements)

References 11 publications

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“…In line with previous studies [16–19], immunosuppression (OR = 4.5 (95% CI: 2.1, 9.7)) was a significant risk factor of mortality among A/H1N1 inpatients in an adjusted multivariate logistic regression analysis. Similarly, chronic lung disease (OR = 3.5) and cancer within the last 12 months (OR = 4.3) were associated with an increase risk of death among A/H1N1 inpatients, which is also in agreement with previous studies [15, 17, 20]. …”

Section: Discussionsupporting

confidence: 91%

Risk Factors for Mortality among 2009 A/H1N1 Influenza Hospitalizations in Maricopa County, Arizona, April 2009 to March 2010

Chowell

Ayala

Berisha

et al. 2012

Computational and Mathematical Methods in Medicine

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We analyzed individual-level data on pandemic influenza A/H1N1pdm hospitalizations from the enhanced surveillance system of the Maricopa County Department of Public Health, AZ, USA from April 1st, 2009 to March 31st, 2010. We also assessed the the risk of death among A/H1N1 hospitalizations using multivariate logistic regression. Hospitalization rates were significantly higher among Native Americans (risk ratio (RR) = 6.2; 95% CI: 6.15, 6.21), non-Hispanic Black (RR = 3.84; 95% CI: 3.8, 3.9), and Hispanics (RR = 2.0; 95% CI: 2.0, 2.01) compared to non-Hispanic Whites. Throughout the spring, 59.2% of hospitalized patients received antiviral treatment; the proportion of patients treated increased significantly during the fall to 74.4% (Chi-square test, P < 0.0001). In our best-fit logistic model, the adjusted risk of death among A/H1N1 inpatients was significantly higher during the fall wave (August 16, 2009 to March 31, 2010, OR = 3.94; 95% CI: 1.72, 9.03) compared to the spring wave (April 1, 2009 to August 15, 2009). Moreover, chronic lung disease (OR = 3.5; 95% CI: 1.7, 7.4), cancer within the last 12 months (OR = 4.3; 95%CI: 1.3, 14.8), immuno-suppression (OR = 4.0; 95% CI: 1.84, 8.9), and admission delays (OR = 4.6; 95% CI: 2.2, 9.5) were significantly associated with an increased the risk of death among A/H1N1 inpatients.

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Section: Discussionsupporting

confidence: 91%

Risk Factors for Mortality among 2009 A/H1N1 Influenza Hospitalizations in Maricopa County, Arizona, April 2009 to March 2010

Chowell

Ayala

Berisha

et al. 2012

Computational and Mathematical Methods in Medicine

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“…The prevalence of high-risk conditions among fatal influenza A(H1N1)pdm09 cases in the U.S. ranged from 68% [20] to 73% [5] and in Brazil was 55% (excluding obesity) [21]. Similar to previous studies [5], [22], [23], [24], [25], [26], [27], [28], [29], [30], diabetes mellitus, cardiovascular disease and chronic lung disease were common underlying medical conditions among influenza A(H1N1)pdm09 virus-associated deaths in Thailand.…”

Section: Discussionsupporting

confidence: 73%

Influenza A(H1N1)pdm09-Associated Pneumonia Deaths in Thailand

et al. 2013

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BackgroundThe first human infections with influenza A(H1N1)pdm09 virus were confirmed in April 2009. We describe the clinical and epidemiological characteristics of influenza A(H1N1)pdm09-associated pneumonia deaths in Thailand from May 2009-January 2010.MethodsWe identified influenza A(H1N1)pdm09-associated pneumonia deaths from a national influenza surveillance system and performed detailed reviews of a subset.ResultsOf 198 deaths reported, 49% were male and the median age was 37 years; 146 (73%) were 20–60 years. Among 90 deaths with records available for review, 46% had no identified risk factors for severe influenza. Eighty-eight patients (98%) received antiviral treatment, but only 16 (18%) initiated therapy within 48 hours of symptom onset.ConclusionsMost influenza A(H1N1)pdm09 pneumonia fatalities in Thailand occurred in adults aged 20–60 years. Nearly half lacked high-risk conditions. Antiviral treatment recommendations may be especially important early in a pandemic before vaccine is available. Treatment should be considered as soon as influenza is suspected.

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“…The number of comorbidities, which increases with age, was an important factor in this respect, as shown by other studies made of the pandemic [23,31]. The World Health Organization working group on risk factors associated with severe A (H1N1) 2009 virus infection found that the proportion of cases with chronic disease increased significantly in tandem with disease severity.…”

Section: Discussionmentioning

confidence: 73%

“…The relationship between specific unfavourable medical conditions and the severity of influenza infection has been widely studied with respect to the 2009 pandemic [23,31,32]. The number of comorbidities, which increases with age, was an important factor in this respect, as shown by other studies made of the pandemic [23,31].…”

Section: Discussionmentioning

confidence: 99%

“…However, the virulence of the disease was particularly high among people aged ≥ 65 years: while the incidence in the community was low in this age group, the proportion of severe, hospitalized cases was higher. In Spain, it is estimated that 2.5% of all cases of influenza attended by primary care centres were in people aged ≥ 65 years, compared with 10.6% admitted to hospital intensive care units [23]. …”

Section: Introductionmentioning

confidence: 99%

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Social factors related to the clinical severity of influenza cases in Spain during the A (H1N1) 2009 virus pandemic

Mayoral¹,

Alonso

Garín

et al. 2013

BMC Public Health

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BackgroundDuring the 2009 influenza pandemic, a change in the type of patients most often affected by influenza was observed. The objective of this study was to assess the role of individual and social determinants in hospitalizations due to influenza A (H1N1) 2009 infection.MethodsWe studied hospitalized patients (cases) and outpatients (controls) with confirmed influenza A (H1N1) 2009 infection. A standardized questionnaire was used to collect data. Variables that might be related to the hospitalization of influenza cases were compared by estimation of the odds ratio (OR) and 95% confidence intervals (CI) and the variables entered into binomial logistic regression models.ResultsHospitalization due to pandemic A (H1N1) 2009 influenza virus infections was associated with non-Caucasian ethnicity (OR: 2.18, 95% CI 1.17 − 4.08), overcrowding (OR: 2.84, 95% CI 1.20 − 6.72), comorbidity and the lack of previous preventive information (OR: 2.69, 95% CI: 1.50 − 4.83). Secondary or higher education was associated with a lower risk of hospitalization (OR 0.56, 95% CI: 0.36 − 0.87)ConclusionsIn addition to individual factors such as comorbidity, other factors such as educational level, ethnicity or overcrowding were associated with hospitalization due to A (H1N1) 2009 influenza virus infections.

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Casos de infección por gripe pandémica (H1N1) 2009 hospitalizados en cuidados intensivos en España: factores asociados a riesgo de muerte, abril 2009-enero 2010

Cited by 19 publications

References 11 publications

Risk Factors for Mortality among 2009 A/H1N1 Influenza Hospitalizations in Maricopa County, Arizona, April 2009 to March 2010

Risk Factors for Mortality among 2009 A/H1N1 Influenza Hospitalizations in Maricopa County, Arizona, April 2009 to March 2010

Influenza A(H1N1)pdm09-Associated Pneumonia Deaths in Thailand

Social factors related to the clinical severity of influenza cases in Spain during the A (H1N1) 2009 virus pandemic

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