“…Danger-associated molecular patterns (DAMPs), such as extracellular ATP, are released during tissue damage and activate the inflammasome in macrophages, amplifying inflammation. Inflammasome-induced activation of an intracellular caspase-1/calpain cysteine protease cascade facilitates the formation and release of phosphatidylserinepositive, highly procoagulant microparticles (10). Thus, galectin-3, a molecule contributing to atherothrombosis, is released from monocyte macrophages in exosomes (11).…”