Caspase-11–Mediated Cell Death Contributes to the Pathogenesis of Imiquimod-Induced Psoriasis

Kenealy, Sinead; Manils, Joan; Raverdeau, Mathilde; Muñoz‐Wolf, Natalia; Barber, Gillian; Liddicoat, Alex M.; Lavelle, Ed C.; Creagh, Emma M.

doi:10.1016/j.jid.2019.05.010

Cited by 8 publications

(7 citation statements)

References 17 publications

(17 reference statements)

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“…Caspase-11 has been shown to play a role in the cleavage of GSDMD and development of psoriatic lesions in imiquimod-induced psoriasis in mice. 124 A previous study demonstrated that the caspase-11/4-GSDMD pathway was activated in the liver during alcoholic hepatitis. 125 In a mouse model of alcoholic hepatitis, a caspase-11 deficiency abolished the ductular reaction, hepatocellular death, and liver bacterial load, which implies that caspase-11 contributes to the pathogenesis of alcoholic liver disease.…”

Section: Inflammasome-related Diseasesmentioning

confidence: 98%

“…Psoriasis is a chronic inflammatory skin disease that is characterized by scaling, erythema, and acanthosis with the infiltration of immune cells. Caspase‐11 has been shown to play a role in the cleavage of GSDMD and development of psoriatic lesions in imiquimod‐induced psoriasis in mice 124 . A previous study demonstrated that the caspase‐11/4–GSDMD pathway was activated in the liver during alcoholic hepatitis 125 .…”

Section: Physiological Implicationsmentioning

confidence: 99%

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Inflammasome‐associated cell death: Pyroptosis, apoptosis, and physiological implications

Tsuchiya

2020

Microbiology and Immunology

179

144

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Section: Inflammasome-related Diseasesmentioning

confidence: 98%

Section: Physiological Implicationsmentioning

confidence: 99%

Inflammasome‐associated cell death: Pyroptosis, apoptosis, and physiological implications

Tsuchiya

2020

Microbiology and Immunology

179

144

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“…Despite the importance of caspase-4 and -5 activation in pathogen clearance, their inflammatory signalling is implicated in driving numerous non-infectious inflammatory pathologies ( Salskov-Iversen et al, 2011 ; Flood et al, 2015 ; Kajiwara et al, 2016 ; Kenealy et al, 2019 ; Zaslona et al, 2020a ; Zasłona et al, 2020b ). The exact circumstances leading to inappropriate activation of inflammatory caspases during sterile inflammation is unclear and suggests the existence of endogenous ligands.…”

Section: Lps-independent Activators Of Caspases-4 and -5mentioning

confidence: 99%

Caspase-4 and -5 Biology in the Pathogenesis of Inflammatory Bowel Disease

Smith

Creagh

2022

Front. Pharmacol.

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Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disease of the gastrointestinal tract, associated with high levels of inflammatory cytokine production. Human caspases-4 and -5, and their murine ortholog caspase-11, are essential components of the innate immune pathway, capable of sensing and responding to intracellular lipopolysaccharide (LPS), a component of Gram-negative bacteria. Following their activation by LPS, these caspases initiate potent inflammation by causing pyroptosis, a lytic form of cell death. While this pathway is essential for host defence against bacterial infection, it is also negatively associated with inflammatory pathologies. Caspases-4/-5/-11 display increased intestinal expression during IBD and have been implicated in chronic IBD inflammation. This review discusses the current literature in this area, identifying links between inflammatory caspase activity and IBD in both human and murine models. Differences in the expression and functions of caspases-4, -5 and -11 are discussed, in addition to mechanisms of their activation, function and regulation, and how these mechanisms may contribute to the pathogenesis of IBD.

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“…Dataset analysis showed a significant elevation of caspase-4/5, pro- IL-1β, and GSDMD in human psoriatic lesions. Besides, caspase-11 contributed to the pathogenesis of imiquimod-induced psoriasis in mice through the mediation of GSDMD activation and cell death ( 70 ). The process of GSDMD-dependent pyroptosis also took part in RA through the releasement of inflammatory mediators ( 71 ).…”

Section: Gsdmdmentioning

confidence: 99%

Modulation of Autoimmune and Autoinflammatory Diseases by Gasdermins

et al. 2022

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Autoimmune diseases and autoinflammatory diseases are two types of the immune system disorders. Pyroptosis, a highly inflammatory cell death, plays an important role in diseases of immune system. The gasdermins belong to a pore-forming protein gene family which are mainly expressed in immune cells, gastrointestinal tract, and skin. Gasdermins are regarded as an executor of pyroptosis and have been shown to possess various cellular functions and pathological effects such as pro-inflammatory, immune activation, mediation of tumor, etc. Except for infectious diseases, the vital role of gasdermins in autoimmune diseases, autoinflammatory diseases, and immune-related neoplastic diseases has been proved recently. Therefore, gasdermins have been served as a potential therapeutic target for immune disordered diseases. The review summarizes the basic molecular structure and biological function of gasdermins, mainly discusses their role in autoimmune and autoinflammatory diseases, and highlights the recent research on gasdermin family inhibitors so as to provide potential therapeutic prospects.

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Caspase-11–Mediated Cell Death Contributes to the Pathogenesis of Imiquimod-Induced Psoriasis

Abstract: Data availability statement No datasets were generated or analyzed during this current study.

Cited by 8 publications

References 17 publications

Inflammasome‐associated cell death: Pyroptosis, apoptosis, and physiological implications

Inflammasome‐associated cell death: Pyroptosis, apoptosis, and physiological implications

Caspase-4 and -5 Biology in the Pathogenesis of Inflammatory Bowel Disease

Modulation of Autoimmune and Autoinflammatory Diseases by Gasdermins

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