Caspases, the Enemy Within, and Their Role in Oxidative Stress-Induced Apoptosis of Inner Ear Sensory Cells

Water, Thomas R. Van De; Lallemend, François; Eshraghi, Adrien A.; Ahsan, Syed F.; He, Jianbin; Guzmán, José Eduardo; Polák, Marek; Malgrange, Brigitte; Lefèbvre, Philippe; Staecker, Hinrich; Bałkany, Thomas J.

doi:10.1097/00129492-200407000-00035

Cited by 105 publications

(74 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[18][19][20] To date, 14 caspases have been identified that are broadly divided into two groups, initiator (caspase-6, -8, -9 and -10) and executioner (caspase-2, -3 and -7). 18,21,22 In NIHL, apoptosis resulting from activation of the extrinsic pathway (caspase-8) or the intrinsic pathway (caspase-9) has been observed. 12,13,15,16 These two pathways converge on caspase-3, the final executioner of apoptosis.…”

Section: Introductionmentioning

confidence: 99%

Overexpression of X-linked inhibitor of apoptosis protein protects against noise-induced hearing loss in mice

et al. 2011

View full text Add to dashboard Cite

Apoptosis is responsible for cochlear cell death induced by noise. Here, we show that transgenic (TG) mice that overexpress X-linked inhibitor of apoptosis protein (XIAP) under control of the ubiquitin promoter display reduced hearing loss and cochlear damage induced by acoustic overstimulation (125 dB sound pressure level, 6 h) compared with wild-type (WT) littermates. Hearing status was evaluated using the auditory brainstem response (ABR), whereas cochlear damage was assessed by counts of surviving hair cells (HCs) and spiral ganglion neurons (SGNs) as well as their fibers to HCs. Significantly smaller threshold shifts were found for TG mice than WT littermates. Correspondingly, the TG mice also showed a reduced loss of HCs, SGNs and their fibers to HCs. HC loss was limited to the basal end of the cochlea that detects high frequency sound. In contrast, the ABRs demonstrated a loss of hearing sensitivity across the entire frequency range tested (2-32 kHz) indicating that the hearing loss could not be fully attributed to HC loss alone. The TG mice displayed superior hearing sensitivity over this whole range, suggesting that XIAP overexpression reduces noise-induced hearing loss not only by protecting HCs but also other components of the cochlea.

show abstract

Section: Introductionmentioning

confidence: 99%

Overexpression of X-linked inhibitor of apoptosis protein protects against noise-induced hearing loss in mice

et al. 2011

View full text Add to dashboard Cite

show abstract

“…The formation of free radicals acts directly to destroy phospholipids and as signaling molecules to upregulate cell death pathways leading to apoptosis or necrosis (Davies, 1996;Greenlund, et al, 1995;Deshmukh and Johnson, 1997;Van De Water et al, 2004). The aim of this study was to test the hypothesis that a change in oxidative state and the formation of free radicals play an important role in deafferentationinduced cell death in vivo.…”

Section: Introductionmentioning

confidence: 99%

Effects of antioxidants on auditory nerve function and survival in deafened guinea pigs

Maruyama

Yamagata

Ulfendahl

et al. 2007

Neurobiology of Disease

View full text Add to dashboard Cite

Based on in vitro studies, it is hypothesized that neurotrophic factor deprivation following deafferentation elicits an oxidative state change in the deafferented neuron and the formation of free radicals that then signal cell death pathways. This pathway to cell death was tested in vivo by assessing the efficacy of antioxidants (AOs) to prevent degeneration of deafferented CNVIII spiral ganglion cells (SGCs) in deafened guinea pigs. Following destruction of sensory cells, guinea pigs were treated immediately with Trolox (a water soluble vitamin E analogue) + ascorbic acid (vitamin C) administered either locally, directly in the inner ear, or systemically. Electrical auditory brainstem response (EABR) thresholds were recorded to assess nerve function and showed a large increase following deafness. In treated animals EABR thresholds decreased and surviving SGCs were increased significantly compared to untreated animals. These results indicate that a change in oxidative state following deafferentation plays a role in nerve cell death and antioxidant therapy may rescue SGCs from deafferentation-induced degeneration.

show abstract

“…Caspases (CASP), with 14 known members, comprise a family characterized by highly conserved intracellular aspartate-specific cysteine proteases (Van De Water et al, 2004;Mittal et al, 2011). Two types are recognized in the CASP family: initiator caspases and effector caspases.…”

Section: Introductionmentioning

confidence: 99%

“…CASP-2, -8, -9, -10 are initiator caspases and CASP-3, -6, -7 are executioner caspases (Yu et al, 2009). CASP-4 and -5 are not currently classified as initiator or effector, because they are inflammatory enzymes that, in concert with CASP-1, are involved in T-cell maturation (Van De Water et al, 2004). CASP-14 is not involved in apoptosis or inflammation, but instead is involved in skin cell development (Yu et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

A literature-based systematic HuGE review and meta-analysis show that CASP gene family polymorphisms are associated with risk of lung cancer

Zhang¹,

Yang²,

Jin³

et al. 2013

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. The caspase (CASP) gene family is known to be involved in apoptosis, cytokine maturation, cell growth, and differentiation. A large number of single nucleotide polymorphisms (SNPs) in the CASP gene family have been increasingly recognized as important regulators in the development of lung cancer. However, this specific association is still controversial. In this Human Genome Epidemiology review and meta-analysis, we summarized the available evidence associating lung cancer with the CASP gene family. Seven studies, which included 1155 lung cancer cases and 1120 healthy controls, met the inclusion criteria and were included in our meta-analysis. In seven studies, 19 different SNPs have been studied in seven CASP genes, including CASP-1, -2, -5, -7, -8, -9, and -10. Meta-analysis results showed positive associations between heterozygote (A/G) of rs507879 in the CASP-5 gene, the T allele of rs12415607 in the CASP-7 gene, and the T allele and T carrier (C/T+T/T) of rs4645981 in the CASP-9 gene with lung cancer susceptibility [odds ratio (OR) = 1.83, 95% confidence interval (95%CI) = 1.07-3.12, P = 0.03; OR = 1.18, 95%CI = 1.02-1.37, P = 0.03; OR = 1.43, 95%CI = 1.12-1.81, P = 0.004; OR = 1.46, 95%CI = 1.10-1.93, P = 0.009; respectively]. However, we found that homozygote (G/G) of rs2227310 in the CASP-7 gene, del allele, heterozygote (ins/del), and del carrier (ins/del + del/del) of rs3834129 in CASP-8 could be protective factors for lung cancer (OR = 0.17, 95%CI = 0.14-0.21, P = 0.0003; OR = 0.83, 95%CI = 0.72-0.97, P = 0.02; OR = 0.74, 95%CI = 0.64-0.85, P < 0.0001; OR = 0.81, 95%CI = 0.71-0.93, P = 0.002; respectively). In conclusion, based on this meta-analysis, we suggest that SNPs in CASP-5, -7, -8, and -9 are associated with susceptibility to lung cancer.©FUNPEC

show abstract

Caspases, the Enemy Within, and Their Role in Oxidative Stress-Induced Apoptosis of Inner Ear Sensory Cells

Cited by 105 publications

References 28 publications

Overexpression of X-linked inhibitor of apoptosis protein protects against noise-induced hearing loss in mice

Overexpression of X-linked inhibitor of apoptosis protein protects against noise-induced hearing loss in mice

Effects of antioxidants on auditory nerve function and survival in deafened guinea pigs

A literature-based systematic HuGE review and meta-analysis show that CASP gene family polymorphisms are associated with risk of lung cancer

Contact Info

Product

Resources

About