Cassia Angustifolia Primed ASCs Accelerate Burn Wound Healing by Modulation of Inflammatory Response

Tasneem, Saba; Ghufran, Hafiz; Azam, Maryam; Arif, Amna; Bin Umair, Musab; Yousaf, Muhammad Amin; Shahzad, Khurrum; Mehmood, Azra; Malik, Kausar; Riazuddin, Sheikh

doi:10.1007/s13770-023-00594-1

Cited by 4 publications

(1 citation statement)

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“…Studies have shown that plasma SDF1a concentrations in type 2 diabetic patients are higher and higher in non-diabetic. 17 Through Mendelian randomization, we found that increased SDF1a level was associated with increased risk of sensorineural hearing loss, re ecting that SDF1a might be a risk factor for sensorineural hearing loss from the side, which provided a new idea for further exploring its exact sex in sensorineural hearing loss.…”

Section: Discussionmentioning

confidence: 93%

Exploring the causal relationship between inflatmmatory factors and sensorineural hearing loss:a bidirectional Mendelian randomization study

Qiu,

lin,

et al. 2024

Preprint

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Objective: To investigated the causal link between inflammatory variables and sensorineural hearing loss. Study Design: a bidirectional Mendelian randomization study. Set: FinnGen study and the public genome-wide association study (GWAS). Methods: Based on the public genome-wide association study and the FinnGen study, we conducted two Mendelian randomization studies using Inverse Variance Weighted (IVW) as the main method of Mendelian randomization(MR) analysis, using weighted median (MR Egger), Cochrane’ Q, IVW_radial and leave-one-out (LOO) were used for pleiotropy and heterogeneity. Also, We use the MR-PRESSO to evaluate horizontal pleiotropy and test outliers. Results: This study used the IVW method to reveal a correlation between elevated levels of VEGF, SDF1a, IL13, IL10, and IL7 and an increased risk of sensorineural hearing loss. The IVW method (Estimate ods ratio [OR]=1.04, 95% Confidence Interval [CI]: 0.07-1.04, p=0.04, OR=1.10, 95% [CI]: 1.02-1.18, p=0.01, OR=1.04, 95% [CI]: 1.01-1.06, p=0.01, OR=1.06, 95% [CI]: 1.02-1.11, p=0.01, OR=1.05, 95% [CI]: 1.02-1.11 1-1.08, p=0.00), Reverse MR analysis showed that sensorineural hearing loss did not significantly affect the expression of these 41 inflammatory factors. No significant heterogeneity or horizontal pleiotropy was observed in the instrumental variables. Conclusion: This study reveals a positive correlation between high levels of VEGF, SDF1a, IL13, IL10 and IL7 and sensorineural hearing loss, providing new targets for prediction, treatment and prevention of sensorineural hearing loss.

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Section: Discussionmentioning

confidence: 93%