Cassia Cinnamon for the Attenuation of Glucose Intolerance and Insulin Resistance Resulting from Sleep Loss

Jitomir, J; Willoughby, Darryn S.

doi:10.1089/jmf.2008.0128

Cited by 17 publications

(7 citation statements)

References 32 publications

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“…Furthermore, studies using type II diabetic animals reported anti-diabetic effects of cinnamon extract administered at 200 mg/kg for 6 weeks [59]. Multiple human clinical trials have also provided evidence for anti-diabetic effects of cinnamon in patients and healthy subjects [60]–[66]. Mechanistic studies of several biomarkers suggest that the effect of cinnamon is mediated via regulation of multiple genes involved in insulin sensitive and lipogenesis pathways [67]–[69].…”

Section: Discussionmentioning

confidence: 99%

Cinnamomum cassia Bark in Two Herbal Formulas Increases Life Span in Caenorhabditis elegans via Insulin Signaling and Stress Response Pathways

Dosanjh

Lao

et al. 2010

PLoS ONE

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BackgroundProving the efficacy and corresponding mode of action of herbal supplements is a difficult challenge for evidence-based herbal therapy. A major hurdle is the complexity of herbal preparations, many of which combine multiple herbs, particularly when the combination is assumed to be vitally important to the effectiveness of the herbal therapy. This issue may be addressed through the use of contemporary methodology and validated animal models.Methods and Principal FindingsIn this study, two commonly used traditional herbal formulas, Shi Quan Da Bu Tang (SQDB) and Huo Luo Xiao Ling Dan (HLXL) were evaluated using a survival assay and oxidative stress biomarkers in a well-established C. elegans model of aging. HLXL is an eleven herb formula modified from a top-selling traditional herbal formula for the treatment of arthritic joint pain. SQDB consists of ten herbs often used for fatigue and energy, particularly in the aged. We demonstrate here that SQDB significantly extend life span in a C. elegans model of aging. Among all individual herbs tested, two herbs Cinnamomum cassia bark (Chinese pharmaceutical name: Cinnamomi Cortex, CIN) and Panax ginseng root (Chinese pharmaceutical name: Ginseng Radix, GS) significantly extended life span in C. elegans. CIN in both SQDB and HLXL formula extended life span via modulation of multiple longevity assurance genes, including genes involved in insulin signaling and stress response pathways. All the life-span-extending herbs (SQDB, CIN and GS) also attenuated levels of H2O2 and enhanced small heat shock protein expression. Furthermore, the life span-extending herbs significantly delayed human amyloid beta (Aβ)-induced toxicity in transgenic C. elegans expressing human Aβ.Conclusion/SignificanceThese results validate an invertebrate model for rapid, systematic evaluation of commonly used Chinese herbal formulations and may provide insight for designing future evidence-based herbal therapy(s).

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Section: Discussionmentioning

confidence: 99%

Cinnamomum cassia Bark in Two Herbal Formulas Increases Life Span in Caenorhabditis elegans via Insulin Signaling and Stress Response Pathways

Dosanjh

Lao

et al. 2010

PLoS ONE

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“…Multiple studies have reported that cinnamon and its extracts possess the capacity to enhance insulin sensitivity and insulin secretion. 186 Administration of C. cassia and zeylanicum extracts was found to increase plasma insulin in rats. 187 Polyphenols from cinnamon restored pancreatic weight and alleviated mesenteric white fat accumulation related to improved insulin sensitivity in high fat/high fructose (HF/HF)fed rats.…”

Section: Enhancement Of Insulin Sensitivity and Insulin Secretionmentioning

confidence: 99%

Beneficial effects of cinnamon and its extracts in the management of cardiovascular diseases and diabetes

et al. 2021

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“…Most of the studies in humans involving the effects of spices on obesity and diabetes have tested cinnamon (40, 47, 61, 73, 88, 99, 154, 158, 173, 174, 216). All these studies suggested that cinnamon modulated the levels of various biomarkers linked with insulin resistance and obesity favorably.…”

Section: Human Studiesmentioning

confidence: 99%

Targeting Inflammation-Induced Obesity and Metabolic Diseases by Curcumin and Other Nutraceuticals

2010

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Extensive research within the past two decades has revealed that obesity, a major risk factor for type 2 diabetes, atherosclerosis, cancer, and other chronic diseases, is a proinflammatory disease. Several spices have been shown to exhibit activity against obesity through antioxidant and anti-inflammatory mechanisms. Among them, curcumin, a yellow pigment derived from the spice turmeric (an essential component of curry powder), has been investigated most extensively as a treatment for obesity and obesity-related metabolic diseases. Curcumin directly interacts with adipocytes, pancreatic cells, hepatic stellate cells, macrophages, and muscle cells. There, it suppresses the proinflammatory transcription factors nuclear factor-kappa B, signal transducer and activators of transcription-3, and Wnt/β-catenin, and it activates peroxisome proliferator-activated receptor-γ and Nrf2 cell-signaling pathways, thus leading to the downregulation of adipokines, including tumor necrosis factor, interleukin-6, resistin, leptin, and monocyte chemotactic protein-1, and the upregulation of adiponectin and other gene products. These curcumin-induced alterations reverse insulin resistance, hyperglycemia, hyperlipidemia, and other symptoms linked to obesity. Other structurally homologous nutraceuticals, derived from red chili, cinnamon, cloves, black pepper, and ginger, also exhibit effects against obesity and insulin resistance.

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Cassia Cinnamon for the Attenuation of Glucose Intolerance and Insulin Resistance Resulting from Sleep Loss

Cited by 17 publications

References 32 publications

Cinnamomum cassia Bark in Two Herbal Formulas Increases Life Span in Caenorhabditis elegans via Insulin Signaling and Stress Response Pathways

Cinnamomum cassia Bark in Two Herbal Formulas Increases Life Span in Caenorhabditis elegans via Insulin Signaling and Stress Response Pathways

Beneficial effects of cinnamon and its extracts in the management of cardiovascular diseases and diabetes

Targeting Inflammation-Induced Obesity and Metabolic Diseases by Curcumin and Other Nutraceuticals

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