Caste specific modulation of juvenile hormone titers in Apis mellifera

Rembold, Heinz

doi:10.1016/0020-1790(87)90110-7

Cited by 110 publications

(90 citation statements)

References 16 publications

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“…Similarly, nutrient excess may induce apoptosis through the action of high levels of the insulin/insulin receptor pathway (Tachibana et al 2015). In the honeybee brain, the Bsurvival^factor would be JH, the titres of which remain at basal levels until the final phases of the pharate-adult stage (Rembold 1987;Hartfelder and Engels 1998). Thus, it seems that a high nutritional input during larval development may subsequently result in diminished neurogenesis, likely due to lower cell survival.…”

Section: Discussionmentioning

confidence: 99%

The ontogenetic saga of a social brain

et al. 2017

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-Queen and worker honeybees differ in a number of life-history traits, including the size of certain brain regions, such as the mushroom bodies (MBs), which are larger in workers. However, during the larval period, the differential feeding offered to queens promotes faster brain development. As a result, members of this caste have larger brains than workers. This developmental process is accompanied by the higher expression of several neurogenic genes. Nonetheless, a caste-specific shift in relative brain growth occurs during the next developmental stage. The suggested molecular underpinnings of this phenomenon are variations in hormonal environments, which may mediate higher cell death rates in the queen's brain than in the workers'. The brain development of this highly eusocial bee is thus a paradoxical case that may represent an evolutionary by-product of the reproductive division of labour in species with female size diphenism.Apis mellifera / honey bee / development / caste / phenotypic plasticity

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Section: Discussionmentioning

confidence: 99%

The ontogenetic saga of a social brain

et al. 2017

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“…JH and ecdysteroid titers are often negatively correlated in insects, with opposing regulation demonstrated in Drosophila melanogaster (reviewed by Riddiford, 1996), mosquitoes (Aedes atropalpus) L (Birnbaum et al, 1984) and honey bees (Rembold, 1987). Using brain transcriptome data from exposure to methoprene (a JH mimic), we found that Low strain ovaries bias functional processes towards ecdysteroid and neural regulation in contrast to the High strain bees (Fig.2C).…”

Section: Qmp Jh-ecdysteroid Hormone Axes and The Worker Ovarymentioning

confidence: 92%

Regulation of behaviorally associated gene networks in worker honey bee ovaries

Wang

Kocher

Linksvayer

et al. 2012

Journal of Experimental Biology

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Fat body expression of hormone receptor-like in 46 (HR46) and phosphoinositide-dependent kinase-1 (PDK1) correlates with ovary size as well as worker division of labor (Wang et al., 2009). HR46 is a possible nuclear hormone receptor for ecdysteroid hormones Accepted 28 September 2011 SUMMARY Several lines of evidence support genetic links between ovary size and division of labor in worker honey bees. However, it is largely unknown how ovaries influence behavior. To address this question, we first performed transcriptional profiling on worker ovaries from two genotypes that differ in social behavior and ovary size. Then, we contrasted the differentially expressed ovarian genes with six sets of available brain transcriptomes. Finally, we probed behavior-related candidate gene networks in wild-type ovaries of different sizes. We found differential expression in 2151 ovarian transcripts in these artificially selected honey bee strains, corresponding to approximately 20.3% of the predicted gene set of honey bees. Differences in gene expression overlapped significantly with changes in the brain transcriptomes. Differentially expressed genes were associated with neural signal transmission (tyramine receptor, TYR) and ecdysteroid signaling; two independently tested nuclear hormone receptors (HR46 and ftz-f1) were also significantly correlated with ovary size in wild-type bees. We suggest that the correspondence between ovary and brain transcriptomes identified here indicates systemic regulatory networks among hormones (juvenile hormone and ecdysteroids), pheromones (queen mandibular pheromone), reproductive organs and nervous tissues in worker honey bees. Furthermore, robust correlations between ovary size and neural-and endocrine response genes are consistent with the hypothesized roles of the ovaries in honey bee behavioral regulation. Supplementary material available online at

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“…These diets induce a series of endogenous responses that result in differential phenotypes. The most studied endocrine regulator of caste differentiation is juvenile hormone (JH) Rembold, 1987), which shows higher titers during the fourth to fifth instar in queen-destined larvae . Functionally, JH application induces queen-like traits in larvae with a restricted diet (Goewie, 1977;Rembold et al, 1974).…”

Section: Introductionmentioning

confidence: 99%

Insulin-like peptides (AmILP1 and AmILP2) differentially affect female caste development in the honey bee (Apis mellifera)

Wang

Azevedo

Hartfelder

et al. 2013

Journal of Experimental Biology

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SUMMARYThe food a honey bee female larva receives determines whether she develops into a large long-lived fertile queen or a short-lived sterile worker. Through well-established nutrient-sensing and growth-promoting functions in metazoans, the insulin/insulin-like growth factor 1 signaling (IIS) pathway has become a focal topic in investigations on how differences in food environment can be translated into internal signals responsible for queen-worker determination. However, low expression levels of two insulin receptors (AmInRs) in honey bee larvae and the failure of one AmInR to influence caste differentiation are in potential conflict with such a classical growth-promoting role of IIS in queen-worker development. In view of such an apparent contradiction, and the fact that binding partners and affinities of these two AmInRs have not been worked out, we performed a functional study on insulin-like peptide genes (AmILP1 and AmILP2) in honey bee larvae by using a double-stranded RNA (dsRNA)-mediated gene knockdown approach. We found that juvenile hormone (JH) levels were diminished by AmILP1 dsRNA treatment, while the AmILP2 knockdown caused a reduction in ovary size. Blood sugar titers were not significantly affected by the treatments. From these results we conclude that AmILP2 transcript levels may influence specific organ development, such as the ovary and body mass, while more general traits of caste differentiation, such as mandibles, may require additional regulators. In addition, JH production may be regulated by AmILP1 expressed locally in the brain, similar to the function of certain ILPs in Drosophila. Supplementary material available online at

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Caste specific modulation of juvenile hormone titers in Apis mellifera

Cited by 110 publications

References 16 publications

The ontogenetic saga of a social brain

The ontogenetic saga of a social brain

Regulation of behaviorally associated gene networks in worker honey bee ovaries

Insulin-like peptides (AmILP1 and AmILP2) differentially affect female caste development in the honey bee (Apis mellifera)

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