In their recent work on the Castelnuovo-Mumford regularity of the matrix Schubert variety, Pechenik, Speyer, and Weigandt introduced a formula for the degree of any Grothendieck polynomial. We give a new proof of this formula in the special case of vexillary permutations and characterize the set of bumpless pipe dreams which contribute maximal degree terms to the Grothendieck polynomial in this case. We also conjecture a generalization of this characterization to bumpless pipe dreams for non-vexillary permutations. Furthermore, we use bumpless pipe dreams to prove new results about the support of vexillary Grothendieck polynomials, addressing special cases of conjectures of Mészáros, Setiabrata, and St. Dizier.