Casting Light on the Janus-Faced HMG-CoA Reductase Degradation Protein 1: A Comprehensive Review of Its Dualistic Impact on Apoptosis in Various Diseases

Moghadam, Reihaneh Khaleghi; Daraei, Arshia; Haddadi, Maryam; Mardi, Amirhossein; Karamali, Negin; Rezaiemanesh, Alireza

doi:10.1007/s12035-024-03994-z

Mol Neurobiol

2024

DOI: 10.1007/s12035-024-03994-z

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Casting Light on the Janus-Faced HMG-CoA Reductase Degradation Protein 1: A Comprehensive Review of Its Dualistic Impact on Apoptosis in Various Diseases

Reihaneh Khaleghi Moghadam,

Arshia Daraei,

Maryam Haddadi

et al.

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2024

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Cited by 2 publications

References 156 publications

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Role of SEL1L in the progression of solid tumors, with a special focus on its recent therapeutic potential

Darmadi,

Saleh,

Oghenemaro

et al. 2024

Cell Biology International

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Since suppressor/enhancer of Lin‐12‐like (SEL1L) was cloned in 1997, various pieces of evidence from lower species suggest it plays a significant role in protein degradation via the ubiquitin‐proteasome system. The relevance of SEL1L in many aspects of malignant transformation and tumorigenic events has been the subject of research, which has shown compelling in vitro and in vivo findings relating its altered expression to changes in tumor aggressiveness. The Endoplasmic Reticulum (ER) in tumor cells is crucial for preserving cellular proteostasis by inducing the unfolded protein response (UPR), a stress response. A crucial component of the UPR is ER‐associated degradation (ERAD), which guards against ER stress‐induced apoptosis and the removal of unfolded or misfolded proteins by the ubiquitin‐proteasome system. As a protein stabilizer of HMG‐CoA reductase degradation protein 1 (HRD1), one of the main components of ERAD, SEL1L plays an important role in ER homeostasis. Notably, the expression levels of these two proteins fluctuate independently in various cancer types, yet changes in their expression affect the levels of other associated proteins during cancer pathogenesis. Recent studies have also outlined the function of SEL1L in cancer medication resistance. This review explores the value of targeting SEL1L as a novel treatment approach for cancer, focusing on the molecular processes of SEL1L and its involvement in cancer etiology.

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Role of SEL1L in the progression of solid tumors, with a special focus on its recent therapeutic potential

Darmadi,

Saleh,

Oghenemaro

et al. 2024

Cell Biology International

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show abstract

Molecular Mechanism of lncRNAs in Regulation of Breast Cancer Metastasis; a Comprehensive Review

Ahmadi,

Yazdi,

Khastar

et al. 2024

Cell Biochem Biophys

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Casting Light on the Janus-Faced HMG-CoA Reductase Degradation Protein 1: A Comprehensive Review of Its Dualistic Impact on Apoptosis in Various Diseases

Cited by 2 publications

References 156 publications

Role of SEL1L in the progression of solid tumors, with a special focus on its recent therapeutic potential

Role of SEL1L in the progression of solid tumors, with a special focus on its recent therapeutic potential

Molecular Mechanism of lncRNAs in Regulation of Breast Cancer Metastasis; a Comprehensive Review

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