Castleman disease: A single-center case series

Pribyl, Kyle; Vakayil, Victor A; Farooqi, Najiha; Arora, Nivedita; Kreitz, Benjamin; Ikramuddin, Salman; Linden, Michael A.; Harmon, James V.

doi:10.1016/j.ijscr.2021.105650

Cited by 7 publications

(8 citation statements)

References 35 publications

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“…Although Pribyl et al [ 5 ] reported a marginal female predominance among patients with UCD, CD generally affects both sexes equally [ 1 , 13 ]. We found a significant female predominance among our patients with UCD.…”

Section: Discussionmentioning

confidence: 99%

“…Castleman disease (CD), also known as angiofollicular lymph node hyperplasia or giant lymph node hyperplasia, was first described in 1954 [ 1 , 2 , 3 , 4 ]. The two main histological subtypes are the hyaline vascular and plasma cell variants, and a mixed variant is seen occasionally [ 5 ]. It is further classified as unicentric CD (UCD) or multicentric CD (MCD) according to the anatomical distribution of the disease and the number of lymph nodes involved [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

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Castleman Disease: A Multicenter Case Series from Turkey

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et al. 2022

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Objective: Castleman disease (CD) is a rare disease also known as angiofollicular lymph node hyperplasia. The two main histological subtypes are the hyaline vascular and plasma cell variants. It is further classified as unicentric CD (UCD) or multicentric CD (MCD) according to the anatomical distribution of the disease and the number of lymph nodes involved. The aim of this multicenter study was to evaluate all cases of CD identified to date in Turkey to set up a national registry to improve the early recognition, treatment, and follow-up of CD. Materials and Methods: Both adult (n=130) and pediatric (n=10) patients with lymph node or involved field biopsy results reported as CD were included in the study. Patients’ demographic information, clinical and laboratory characteristics, imaging study results, treatment strategies, and clinical outcomes were evaluated retrospectively. Results: A total of 140 patients (69 male and 71 female) with a diagnosis of UCD (n=73) or MCD (n=67) were included. The mean age was 39 years in the UCD group and 47 years in the MCD group. Female patients were more common in the UCD group. The most common histological subtype was hyaline vascular for both UCD and MCD patients. Asymptomatic patients were more common in the UCD group. Anemia, elevations of acute phase reactants, and hypoalbuminemia were more common in the MCD group. The most commonly used treatment strategies for UCD were surgical excision, rituximab, and radiotherapy, respectively. All UCD patients were alive at a median of 19.5 months of follow-up. The most commonly used treatment strategies for MCD were methyl prednisolone, R-CHOP, R-CVP, and rituximab. Thirteen MCD patients had died at a median of 34 months of follow-up. Conclusion: This study is important in presenting the patient characteristics and treatment strategies for CD from Turkey, with the potential of increasing awareness about CD. Treatment data may help in making decisions, particularly in countries that do not have access to siltuximab. However, larger prospective studies are needed to make definitive conclusions.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Castleman Disease: A Multicenter Case Series from Turkey

Gündüz

Kırkızlar

Ümit

et al. 2022

Tjh

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“…Unicentric Castleman’s disease, which mimic PPP, usually shows well-circumscribed and homogenous masses in mediatum with intense reinforcement on enhanced CT scan. Nevertheless, Unicentric Castleman’s disease predominantly consists of the hyaline vessel variant (90%) ( 19 ). Histopathology is the only method to make a definitive diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Solitary extramedullary plasmacytoma in the lung misdiagnosed as lung cancer: A case report and literature review

et al. 2022

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BackgroundExtramedullary plasmacytoma (EMP) is an extremely rare kind of soft tissue plasma cell neoplasm without bone marrow involvement or other systemic characteristics of multiple myeloma. Primary pulmonary plasmacytoma (PPP), with no specific clinical manifestations, is an exceedingly rare type of EMP. Because of its complexity, PPP is often difficult to diagnose. Computed tomography-guided percutaneous core needle biopsy (CT-guided PCNB) has been shown to have high sensitivity, specificity and accuracy for characterization of pulmonary lesion, particularly if malignancy is suspected. Here we presented a rare case of PPP diagnosed with CT-guided PCNB.Case presentationA 78-year-old female smoker who visited our outpatient clinic for a mass in the left lower lobe of the lung. Pathological based on CT-guided PCNB yielded a PPP with no lymph node or other distant metastasis.ConclusionsExtramedullary plasmacytoma should be considered in the differential diagnosis of a pulmonary mass.

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“…Other findings include organomegaly, mainly hepato/splenomegaly, renal dysfunction, and respiratory complications. These individuals tend to have increased inflammatory markers, particularly serum CRP, along with anemia, thrombocytopenia, and characteristic hypergammaglobulinemia [2,4,5,8,14]. POEMS and TAFRO constitute the most severe forms of MCD and, if left untreated, can lead to life-threatening multiple organ dysfunction syndrome (MODS) [7].…”

Section: Discussionmentioning

confidence: 99%

Idiopathic Multicentric Castleman Disease with Cutaneous Manifestation: Case Report

et al. 2022

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Castleman disease constitutes a rare class of lymphoproliferative disorders, with an estimated incidence of 21 to 25 per million patient years. The idiopathic subtype exhibits a significantly diverse clinical presentation, which can imitate many autoimmune, malignant, and infectious diseases. Cutaneous manifestations are uncommon and require in-depth investigation, especially when concurrent lymphadenopathy is present. A 79-year-old female, with a chronic, complicated erysipelas-like lesion, presented with bilaterally enlarged inguinal lymph nodes; after surgical excision, their histopathological examination revealed Castleman disease. Even though it is a benign condition, patients are often predisposed to developing certain types of malignancies, which can deteriorate their prognosis. An accurate and early diagnosis, along with effective treatment and prevention of recurrence, is of utmost importance in order to increase the patients’ overall survival and quality of life.

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Castleman disease: A single-center case series

Cited by 7 publications

References 35 publications

Castleman Disease: A Multicenter Case Series from Turkey

Castleman Disease: A Multicenter Case Series from Turkey

Solitary extramedullary plasmacytoma in the lung misdiagnosed as lung cancer: A case report and literature review

Idiopathic Multicentric Castleman Disease with Cutaneous Manifestation: Case Report

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