Castleman disease: unusual manifestations of an unusual disorder.

Abstract

Castleman disease was originally described in 1954 as a form of localized mediastinal lymph-node hyperplasia. It has also been reported as a solitary mass in the hilar region or peripheral lymph nodes. The authors describe 4 cases, 3 in the chest and 1 in the neck. The intrathoracic lesions involved (a) the middle portion of the superior mediastinum with extension into the neck, (b) the posterior paravertebral mediastinum with extension into the posterior intercostal spaces, and (c) the extrapleural posterior chest wall, respectively: this last case is unusual in that the tumor recurred in the same site several years after removal. The clinical, radiological, and pathological features are presented.

Prolonged fever as an unusual manifestation of the hyaline vascular type of Castleman’s disease in the chest: report and review of the literature

“…Other reported locations are muscle, larynx, floor of the mouth, shoulder, arm, vulva, pericardium, and cranium [4,11,21]. Castleman's disease may arise from unusual locations of the chest such as the intercostal space [22], an intrapulmonary fissure [23], and the middle portion of the superior mediastinum with extension into the neck [24].…”

Pancreatic castleman disease: CT findings

“…Two histological forms have been described [1][2][3]: (1) the hyaline vascular form (90%), usually occurring in asymptomatic young healthy people and detected mostly by routine chest x-ray; (2) the plasma-cell type (10%) may be associated with systemic manifestations such as anemia, fever, and hyperglobulinemia. This second form may be distinguished histologically by larger…”

Pseudo-Adrenal Incidentaloma: Magnetic Resonance Imaging in a Patient with Para-Adrenal Castleman’s Disease

“…However, multicentric lesions [11], which encompass both pathologic classifications, often show severe systemic symptoms and usually have a poor prog nosis, but they are rarely found. Although several etiologi cal hypotheses have been proposed [4-6, 8, 12], this disor der is likely to be caused by some immunological reac tions to inflammation [4][5][6], Since the most common type of the disease is HV, which is usually asymptomatic and found in the mediasti num [4,13,14], it is incidentally discovered by chest roentgenogram in most cases [15][16][17], Retroperitoneal development of these masses is considerably rare. Ac cording to Honda et al [ 14], who analyzed 439 cases, only 28 lesions (6.4%) were found in the retroperitoneum.…”

“…The ultrasonographic findings of Castleman's disease were reported to be soft and hypoechoic [ 10, [18][19][20][21]. On CT, it is being depicted as a homo geneous soft mass [ 10, [15][16][17][18][19][20][21], However, there is some controversy in the findings after the administration of contrast medium; either there is an enhancement [17,18,21 ], especially an early and homogeneous enhancement on the postcontrast dynamic CT study [ 16,21], or no enhancement [ 19,21 ] as in the present case. Such a differ ence in enhancement has no correlation with the histo logic type (HV or PC type).…”