Castleman's disease arising from the intercostal space

Abstract

A 27-year-old woman was investigated for a tumour of the posterior chest wall. This was excised surgically and histologically it proved to be a hyaline vascular type of angiofollicular lymphoid hyperplasia or Castleman's disease. This is the third case from the literature of such a tumour arising from the intercostal space. Surgical excision has been proved curative until now with no recurrence.

Castleman Disease: The Great Mimic

“…Pleural Castleman disease is unusual and can manifest as a well-defined mass or with an associated pleural effusion (15). and simulate other chest wall masses (17). Intercostal Castleman disease can show rib erosion .…”

Imaging Spectrum of Castleman's Disease

“…5A and 5B). Intercostal Castleman's disease may manifest as an extrapulmonary mass with rib erosion [6]. Intrapulmonary Castleman's disease may appear A, Posteroanterior chest radiograph shows widened anterior mediastinum (arrows) mimicking thymoma or lymphoma.…”

Prolonged fever as an unusual manifestation of the hyaline vascular type of Castleman’s disease in the chest: report and review of the literature

“…Other reported locations are muscle, larynx, floor of the mouth, shoulder, arm, vulva, pericardium, and cranium [4,11,21]. Castleman's disease may arise from unusual locations of the chest such as the intercostal space [22], an intrapulmonary fissure [23], and the middle portion of the superior mediastinum with extension into the neck [24].…”

“…The most frequent hematologic abnormalities are anemia, elevated ESR, thrombocytosis, hyperglobulinemia, hypoalbuminemia, and leukocytosis [8,30]. Anemia does not response to exogenous iron therapy [8,22]. Unusual clinical features such as peripheral neuropathy, myasthenia gravis, growth retardation, erosive stomatitis and keratitis, nephrotic syndrome, amyloidosis, thrombotic thrombocytopenia purpura, myelofibrosis, cardiac tamponade, and recurrent pleural effusion have been reported in the literature [31][32][33][34].…”