Castleman′s disease with paraneoplastic pemphigus

Dinesha,; Padyana, Mahesha; Nayak, Kashinath; Murali, Nirupama; Pai, Deepti

doi:10.4103/0019-5154.135528

Cited by 12 publications

(4 citation statements)

References 6 publications

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“…Their courses were more severe, and they died of sepsis, complications from bronchiolitis obliterans, and a ventricular arrhythmia, respectively. 5,10,13 The other nine patients reported either minimal or no symptoms of MG at follow-up.…”

Section: Discussionmentioning

confidence: 98%

“…only one such case of MCD (Table 1). [3][4][5][6][7][8][9][10][11][12][13][14] Of the 12 UCD cases, 10 (83%) involve the hyaline vascular subtype of UCD, while the other 2 involve the mixed-cell variety. Eight cases (67%) presented with symptoms of MG, three (25%) presented with erosive skin and mucosal lesions of pemphigus before MG symptoms developed, and one (8%) presented as an acute abdomen.…”

Section: Discussionmentioning

confidence: 99%

“…Myasthenia gravis (MG) has been reported in 11 previous cases of UCD and one case of MCD, while optic disc edema initially described as pseudotumour cerebri (PTC) has been noted in five cases of MCD. [3][4][5][6][7][8][9][10][11][12][13][14][15][16] To our knowledge, there have been no cases published that involve all three of these disorders. We describe the case of a young female patient who developed PTC and MG in the context of UCD, and provide a review of the literature involving the intersection of these disorders.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Castleman Disease Presenting with Pseudotumour Cerebri and Myasthenia Gravis: A Case Report and Literature Review

Fein

Bittar

Shende

et al. 2018

Neuro-Ophthalmology

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Castleman disease (CD) is a rare lymphoproliferative disorder that may present with various autoimmune, inflammatory, or neurologic syndromes. This is a case of a 21-year-old woman who presented with signs and symptoms of pseudotumour cerebri (PTC) who subsequently developed myasthenia gravis (MG), and was incidentally found to have a large mass in the posterior mediastinum. Upon resection, the mass was classified as unicentric CD involved with follicular dendritic cell sarcoma. Following treatment with IVIG in the setting of progressive weakness and dyspnea, she has had complete symptom resolution while maintained on a low dose of pyridostigmine for the last two years. There are 13 cases of MG and five cases of optic disc edema described as PTC associated with CD in the literature, but to our knowledge, this is the sole case reported of the intersection of all three conditions in one patient. Increased serum levels of interleukin-6 and vascular endothelial growth factor may provide clues as to the association of CD with these neurologic syndromes.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Castleman Disease Presenting with Pseudotumour Cerebri and Myasthenia Gravis: A Case Report and Literature Review

Fein

Bittar

Shende

et al. 2018

Neuro-Ophthalmology

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“…12,13 From a clinical perspective, Castleman disease has very diverse manifestations that may range from mass effect symptomatology to constitutional symptoms and paraneoplastic pemphigus, albeit in many instances patients are asymptomatic. 14 Castleman disease is associated with a number of other disease entities such as various types of lymphoma, follicular dendritic cell sarcoma, Kaposi sarcoma and POEMS syndrome. 15,16 The clinical and histopathological heterogeneity along with the diverse sites and organs that can be involved, render the distinction of Castleman disease from its malignant and benign mimics challenging.…”

Section: Introductionmentioning

confidence: 99%

Castleman Disease with MDM2/CDK4 Protein Expression: a Potential Mimic of Inflammatory Variant of Liposarcoma with Significant Consequences

et al. 2022

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Castleman disease is a rare benign lymphoproliferative disorder that includes a spectrum of distinct histopathological entities. The differential diagnosis of Castleman disease is broad and includes lymphomas, HIV-related lymphadenopathy, autoimmune disorders, and inflammatory liposarcoma. When Castleman disease occurs in the retroperitoneum, the distinction from the inflammatory variant of well-differentiated liposarcoma can be very challenging in small biopsies. Herein we report a case of Castleman disease that presented as a retroperitoneal mass and expressed MDM2 and CDK4 by immunohistochemistry. To our knowledge, this is the first report of Castleman disease staining positively for MDM2/CDK4, and it underscores how immunohistochemistry can potentially serve as a pitfall when differentiating this rare entity from retroperitoneal sarcomas.

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Paraneoplastic Pemphigus and Autoimmune Blistering Diseases Associated with Neoplasm: Characteristics, Diagnosis, Associated Neoplasms, Proposed Pathogenesis, Treatment

et al. 2016

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Autoimmune paraneoplastic and neoplasm-associated skin syndromes are characterized by autoimmune-mediated cutaneous lesions in the presence of a neoplasm. The identification of these syndromes provides information about the underlying tumor, systemic symptoms, and debilitating complications. The recognition of these syndromes is particularly helpful in cases of skin lesions presenting as the first sign of the malignancy, and the underlying malignancy can be treated in a timely manner. Autoimmune paraneoplastic and neoplasm-associated bullous skin syndromes are characterized by blister formation due to an autoimmune response to components of the epidermis or basement membrane in the context of a neoplasm. The clinical manifestations, histopathology and immunopathology findings, target antigens, associated neoplasm, current diagnostic criteria, current understanding of pathogenesis, and treatment options for a selection of four diseases are reviewed. Paraneoplastic pemphigus manifests with clinically distinct painful mucosal erosions and polymorphic cutaneous lesions, and is often associated with lymphoproliferative neoplasm. In contrast, bullous pemphigoid associated with neoplasm presents with large tense subepidermal bullae of the skin, and mild mucosal involvement, but without unique clinical features. Mucous membrane pemphigoid associated with neoplasm is a disorder of chronic subepithelial blisters that evolve into erosions and ulcerations that heal with scarring, and involves stratified squamous mucosal surfaces. Linear IgA dermatosis associated with neoplasm is characterized by annularly grouped pruritic papules, vesicles, and bullae along the extensor surfaces of elbows, knees, and buttocks. Physicians should be aware that these autoimmune paraneoplastic and neoplasm-associated syndromes can manifest distinct or similar clinical features as compared with the non-neoplastic counterparts.

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Castleman′s disease with paraneoplastic pemphigus

Cited by 12 publications

References 6 publications

Castleman Disease Presenting with Pseudotumour Cerebri and Myasthenia Gravis: A Case Report and Literature Review

Castleman Disease Presenting with Pseudotumour Cerebri and Myasthenia Gravis: A Case Report and Literature Review

Castleman Disease with MDM2/CDK4 Protein Expression: a Potential Mimic of Inflammatory Variant of Liposarcoma with Significant Consequences

Paraneoplastic Pemphigus and Autoimmune Blistering Diseases Associated with Neoplasm: Characteristics, Diagnosis, Associated Neoplasms, Proposed Pathogenesis, Treatment

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