2017
DOI: 10.1093/omcr/omx021
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Castleman's disease with TAFRO syndrome: a case report from Syria

Abstract: Castleman's disease is a rare disorder, yet a rarer newly described syndrome called TAFRO syndrome was discovered to accompany it. TAFRO represents the constellation of symptoms (Thrombocytopenia, Anasarca, MyeloFibrosis, Renal failure, Organomegaly). Most cases were described in Japan. We present the first case of TAFRO syndrome in Syria. A 58-year-old Caucasian male with no relevant history presented with fatigue, oliguria, decreased platelets, increased creatinine level, hepatosplenomegaly, ascites, pitting… Show more

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Cited by 7 publications
(6 citation statements)
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“…[ 1 ] Most cases of TAFRO syndrome have been reported in Japan, and more recently also in Europe, [ 3 , 4 ] North America, [ 5 , 6 ] South America, [ 7 ] and Western Asia. [ 8 ] As case reports have accumulated, its distinct clinical characteristics have become more obvious and in 2015, updated diagnostic criteria were proposed. [ 2 ] According to these criteria, the presence of all 3 major and at least 2 of the 4 minor criteria is necessary for diagnosis of TAFRO syndrome.…”
Section: Discussionmentioning
confidence: 99%
“…[ 1 ] Most cases of TAFRO syndrome have been reported in Japan, and more recently also in Europe, [ 3 , 4 ] North America, [ 5 , 6 ] South America, [ 7 ] and Western Asia. [ 8 ] As case reports have accumulated, its distinct clinical characteristics have become more obvious and in 2015, updated diagnostic criteria were proposed. [ 2 ] According to these criteria, the presence of all 3 major and at least 2 of the 4 minor criteria is necessary for diagnosis of TAFRO syndrome.…”
Section: Discussionmentioning
confidence: 99%
“…TAFRO syndrome has been reported mostly in Japan, though it has recently been reported in other countries 7‐10 . TAFRO syndrome was first defined as a novel systemic inflammatory disease at a consensus meeting of medical professionals and researchers in Japan in 2012 1 .…”
Section: Discussionmentioning
confidence: 99%
“…TAFRO syndrome has been reported mostly in Japan, though it has recently been reported in other countries. [7][8][9][10] TAFRO syndrome was first defined as a novel systemic inflammatory disease at a consensus meeting of medical professionals and researchers in Japan in 2012. 1 Masaki et al proposed a classification for diagnostic criteria and disease severity based on 28 cases of TAFRO syndrome in 2015.…”
Section: F I G U R E 1 Chest Computed Tomography Shows Enlarged Lymph Nodes At the Bilateral Axillary Area (White Arrow Heads) (A) And Plmentioning
confidence: 99%
“…TAFRO syndrome can occur in any age and any race, but it is more common in East Asian populations, especially Japanese and mostly occurs in the middle-aged and elderly (Alhoulaiby et al 2017;Coutier et al 2017;Finocchietto et al 2015;Kubokawa et al 2014;Liu et al 2016;Owattanapanich et al 2018). 7.3% (7/96) of HIVnegative CD and 15.9% (7/44) of MCD patients in our center were diagnosed with TAFRO syndrome, the rate was higher than the reported rate by Oksenhendler et al (2018) who described that 7% (2/27) of French iMCD consistent with TAFRO syndrome (Oksenhendler et al (2018), but lower than the results of Owattanapanich et al (2018) of 18.2% (6/33).…”
Section: Discussionmentioning
confidence: 99%