CAT C-262T and GPX1 Pro198Leu polymorphisms in a Turkish population

Süzen, Sinan; Gucyener, Emel; Sakalli, Ozgul; Uçkun, Zuhal; Kose, Gulcin; Ustel, Duygu; Duydu, Yalçın

doi:10.1007/s11033-009-9540-4

Cited by 41 publications

(37 citation statements)

References 35 publications

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“…The CAT -262C/T, GPX1 Pro198Leu and SOD1 +35A/C polymorphisms were associated with an increased risk of glaucoma. These findings support the hypothesis that genetic variations in antioxidant defense may modify the risk of glaucoma among individuals with elevated oxidative stress or decreased antioxidant capacity [33,34,35,36]. The present study examines the effect of serum SOD1, GPX and CAT1 level on the eye.…”

Section: Discussionsupporting

confidence: 84%

The role of Cat -262C/T, GPX1 Pro198Leu and Sod1+35A/C gene polymorphisms in a development of primary open-angle glaucoma in a Polish population

Malinowska¹,

Kowalski²,

Szaflik³

et al. 2016

pjp

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The development of glaucoma may be connected with a long-term exposure to oxidative stress caused by free radical (ROS). The main aim of this work was an analysis of associations of Cat-262C/T, GPX1 Pro198Leu and SOD1 35 A/C gene polymorphisms of antioxidant enzymes with a risk of open-angle glaucoma (POAG) in a Polish population. DNA samples collected from 209 patients with POAG and 191 healthy controls were used in this study. Polymorphisms were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). We found that the +35A/C polymorphisms of SOD1 were not associated with a risk of POAG. We found that C/T genotype (1-GPX1Pro198Leu, 2-Cat C262T) is associated with increased risk of open angle glaucoma (1-OR = 2.24; 95% CI: 1.46-3.44; p = 0.0001, 2-OR = 2.16; 95% CI: 1.35-3.34; p = 0.001). We also found that T/T genotype is a risk factor for progression of POAG (1-OR = 3.86; 95% Cl: 1.36-10.96; p = 0.007, 2-OR = 6.37; 95% CI: 1.39-29.28; p = 0.007). Finally our data suggest that gene polymorphisms of GPX1 Pro198Leu and CAT C262T may have a protective role in the development of primary open-angle glaucoma in a Polish population.

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Section: Discussionsupporting

confidence: 84%

The role of Cat -262C/T, GPX1 Pro198Leu and Sod1+35A/C gene polymorphisms in a development of primary open-angle glaucoma in a Polish population

Malinowska¹,

Kowalski²,

Szaflik³

et al. 2016

pjp

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“…They are widely distributed within the coding and noncoding regions of the GPx1 gene as reported in OMIM database (ID: 138320) and dbSNP records (www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?locusId=2876). A variant most known within the coding region is Pro198Leu polymorphism (Suzen et al, 2010). The rs 1800668 (C/T) variant, investigated in the study, is also located within the GPx1gene promoter.…”

Section: Introductionmentioning

confidence: 96%

Phenotype and genotype relationship of glutathione peroxidase1 (GPx1) and rs 1800668 variant: The homozygote effect on kinetic parameters

Najafi¹,

Ghasemi²,

Roustazadeh³

et al. 2012

Gene

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“…Human glutathione peroxidase (GPX) is an antioxidant enzyme that is expressed in blood vessels (Suzen et al, 2010). Its role is protection of cells against oxidative damage by reducing hydrogen peroxide and a wide range of organic peroxidases to H 2 O 2 with reduced glutathione.…”

Section: Introductionmentioning

confidence: 99%

Genetic polymorphisms of paraoxonase1 192 and glutathione peroxidase1 197 enzymes in familial Mediterranean fever

Öktem¹,

Anıl²,

Sütçü³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. Familial Mediterranean fever (FMF) is an autosomal recessive disorder and is the most frequent of the periodic febrile inflammatory syndromes. The pathogenesis of the disease is not completely understood, even though the FMF gene has been identified. Oxidative stress and inflammation may play a role in the pathogenesis of FMF. We investigated gene polymorphisms of the antioxidative enzymes, glutathione peroxidase (GPX) and paraoxonase (PON) in FMF patients, and possible associations with FMF pathogenesis. Sixty FMF patients during an attack-free period and 51 healthy children as the control group were included in our study. PON1 Q/R192 and GPX1 Pro197Leu gene polymorphisms were assayed. Blood urea nitrogen, creatinine and serum lipid profile were also measured. PON1 Q/R192 genotype distribution was 52% QQ, 46% QR and 2% RR in the FMF group and 45% QQ, 45% QR and 10% RR in the control group (P > Familial Mediterranean fever 0.05). GPX1 Pro197Leu genotype distribution was 28% PP, 57% PL, 15% LL in the FMF group and 18% PP, 53% PL, 29% LL in the control group (P > 0.05). Blood urea nitrogen, serum creatinine, lipid levels, and the distribution of PON1 Q/R192 and GPX1 Pro197Leu genotypes were similar in the two groups. We conclude that the PON1 Q/R192 and GPX1 Pro197Leu gene polymorphisms are not important risk factors in the development of FMF. However, larger studies are warranted to validate these conclusions.

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CAT C-262T and GPX1 Pro198Leu polymorphisms in a Turkish population

Cited by 41 publications

References 35 publications

The role of Cat -262C/T, GPX1 Pro198Leu and Sod1+35A/C gene polymorphisms in a development of primary open-angle glaucoma in a Polish population

The role of Cat -262C/T, GPX1 Pro198Leu and Sod1+35A/C gene polymorphisms in a development of primary open-angle glaucoma in a Polish population

Phenotype and genotype relationship of glutathione peroxidase1 (GPx1) and rs 1800668 variant: The homozygote effect on kinetic parameters

Genetic polymorphisms of paraoxonase1 192 and glutathione peroxidase1 197 enzymes in familial Mediterranean fever

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