Cat-Scratch Disease In Adult Hospitalized For Prolonged-Fever Associated With Multiple Lymphadenopathies and Weight Loss

Guiyedi, Vincent; Haddad, Hanna; Okome-Nkoumou, M; Gire, Fabien; Ongali, Brice; Lore, P.; Gameiro, Luís Felipe Orsi

doi:10.2174/1874285801307010152

Cited by 5 publications

(4 citation statements)

References 22 publications

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“…Several Bartonella spp. have been reported as cause of fever of unknown origin and culture-negative endocarditis in humans and animals [ 102 – 105 ]. In humans, endocarditis caused by B. henselae , B. quintana , B. elizabethae , B. vinsonii subsp.…”

Section: Bartonella Spp Infections Of Humansmentioning

confidence: 99%

Bartonella spp. - a chance to establish One Health concepts in veterinary and human medicine

2016

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Infectious diseases remain a remarkable health threat for humans and animals. In the past, the epidemiology, etiology and pathology of infectious agents affecting humans and animals have mostly been investigated in separate studies. However, it is evident, that combined approaches are needed to understand geographical distribution, transmission and infection biology of “zoonotic agents”. The genus Bartonella represents a congenial example of the synergistic benefits that can arise from such combined approaches: Bartonella spp. infect a broad variety of animals, are linked with a constantly increasing number of human diseases and are transmitted via arthropod vectors. As a result, the genus Bartonella is predestined to play a pivotal role in establishing a One Health concept combining veterinary and human medicine.

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Section: Bartonella Spp Infections Of Humansmentioning

confidence: 99%

Bartonella spp. - a chance to establish One Health concepts in veterinary and human medicine

2016

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“…Bartonella spp. are a cause of FUO and culture-negative endocarditis [ 17 – 20 ]. As reviewed by Chomel, et al .…”

Section: Resultsmentioning

confidence: 99%

Did Bartonella henselae contribute to the deaths of two veterinarians?

Breitschwerdt

2015

Parasites Vectors

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Bartonella henselae, a flea-transmitted bacterium, causes chronic, zoonotic, blood stream infections in immunocompetent and immunocompromised patients throughout the world. As an intra-erythrocytic and endotheliotropic bacterium, B. henselae causes a spectrum of symptomatology ranging from asymptomatic bacteremia to fever, endocarditis and death. Veterinary workers are at occupational risk for acquiring bartonellosis. As an emerging, and incompletely understood, stealth bacterial pathogen, B. henselae may or may not have been responsible for the deaths of two veterinarians; however, recent evidence indicates that this genus is of much greater medical importance than is currently appreciated by the majority of the biomedical community.

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“…Doxycycline can be optionally used; however, the drug is contraindicated in children (under the age of 8 years in Poland) and pregnant women. In typical uncomplicated cases, azithromycin is administered for 5 days (therapy continuation for several weeks is needed in some cases) (23)(24)(25) .…”

Section: Cat Scratch Disease -Bartonellosis (Rickettsiosis)mentioning

confidence: 99%

Azithromycin – more than an antibiotic

Sybilski¹

2020

Pediatr Med Rodz

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Azithromycin, which belongs to the azalide subclass, is a derivative of erythromycin, obtained by inserting a methyl substituted nitrogen atom into the lactone ring. In this way, better stability at the low pH of the gastric juice, improved bioavailability, and an extended half-life relative to erythromycin were achieved. The mechanism of azithromycin antibacterial activity is to inhibit bacterial cell protein synthesis by binding to the 50S ribosomal subunit and preventing bacterial mRNA translation and protein biosynthesis. In addition to bactericidal activity, azithromycin also has immunomodulatory, anti-inflammatory, and antiviral properties. For this reason, it is used in exacerbations of asthma and chronic obstructive pulmonary disease. However, its antibacterial efficacy and high safety are most important. In clinical practice, several model clinical profiles of patients can be presented: children with community-acquired Mycoplasma pneumoniae pneumonia, recurrent respiratory tract infections and exacerbations of chronic inflammations, acute bronchitis of likely bacterial aetiology, tonsillitis and allergy to β-lactam antibiotics, and pertussis. Efficacy has also been proven in primary skin and soft tissue infections as well as erysipelas. However, azithromycin may also have an unusual use, as confirmed by recent reports. These include travellers’ diarrhoea, cat scratch disease (bartonellosis – rickettsiosis), and mycobacteriosis (nontuberculous mycobacteria). Appropriate spectrum of action, efficacy and safety, as well as a low percentage of resistant bacteria, good bioavailability, easy to remember, practical and simple dosage regimen and optimal cost are features of a good antibiotic. Azithromycin is close to meeting all these criteria.

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Cat-Scratch Disease In Adult Hospitalized For Prolonged-Fever Associated With Multiple Lymphadenopathies and Weight Loss

Cited by 5 publications

References 22 publications

Bartonella spp. - a chance to establish One Health concepts in veterinary and human medicine

Bartonella spp. - a chance to establish One Health concepts in veterinary and human medicine

Did Bartonella henselae contribute to the deaths of two veterinarians?

Azithromycin – more than an antibiotic

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