Catabolism and urinary excretion of albumin and transferrin before and after intravenous injection of albumin in the rat: With observations on the urinary excretion of IgG globulin

Gardiner, Michaele E.; Finlay-Jones, Judith-Mary; Morgan, Evan H.

doi:10.1016/0006-2944(73)90033-1

Biochemical Medicine

1973

DOI: 10.1016/0006-2944(73)90033-1

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Catabolism and urinary excretion of albumin and transferrin before and after intravenous injection of albumin in the rat: With observations on the urinary excretion of IgG globulin

Michaele E. Gardiner

Judith-Mary Finlay-Jones

Evan H. Morgan

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1977

1981

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Die Regulation des Serumalbuminspiegels unter physiologischen und pathologischen Bedingungen

Weigand

1977

Klin Wochenschr

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12 g of albumin are synthesized daily by the bound polyribosomes of all human liver cells together, corresponding to 10% of the intravascular albumin mass. The cell is producing a precursor albumin. During secretion albumin is liberated by splitting of a small peptide. Only 40% of the total body albumin is located intravascularly. 12g of albumin are degraded or excreted daily, 30% of it by the liver, the kidneys and the gastrointestinal tract. The main site of albumin catabolism is unknown. Albumin with a half-life of about 20 days is degraded at a constant fractional catabolic rate. The absolute rate of degradation varies depending on the plasma content. This mechanism allows an effective regulation of the serum albumin level. The fractional catabolic rate, however, is not completely fixed. It is slowly reduced if the serum albumin content is markedly reduced as in protein deficiency, the blind loop syndrome, cirrhosis, nephrosis, and diseases of the gastrointestinal tract. Infusion of albumin increases the fractional catabolic rate slowly. This must be taken in consideration substitution albumin in chronic diseases. The shift from the extravascular to the intravascular compartment is a short-term regulatory mechanism. The regulation of synthesis and degradation are independent from each other. The molecular mechanism of regulation of synthesis and degradation are unknown, partially due to inadequate methods.

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Die Regulation des Serumalbuminspiegels unter physiologischen und pathologischen Bedingungen

Weigand

1977

Klin Wochenschr

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Transferrin, biochemistry, physiology and clinical significance

Morgan

1981

Molecular Aspects of Medicine

292

131

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Catabolism and urinary excretion of albumin and transferrin before and after intravenous injection of albumin in the rat: With observations on the urinary excretion of IgG globulin

Cited by 2 publications

References 23 publications

Die Regulation des Serumalbuminspiegels unter physiologischen und pathologischen Bedingungen

Die Regulation des Serumalbuminspiegels unter physiologischen und pathologischen Bedingungen

Transferrin, biochemistry, physiology and clinical significance

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