Catabolism of citrus flavanones by the probiotics Bifidobacterium longum and Lactobacillus rhamnosus

Pereira-Caro, Gema; Fernández-Quirós, Begoña; Ludwig, Iziar A.; Pradas, Inmaculada; Crozier, Alan; Moreno-Rojas, José Manuel

doi:10.1007/s00394-016-1312-z

Cited by 58 publications

(47 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The gastrointestinal tract plays a significant role in the metabolism and conjugation of polyphenols, because the polyphenols must pass through it before being absorbed into the bloodstream and distributed. However, not all polyphenols released in the distal GI tract are absorbed intact; many of them are metabolized by microbiota‐mediated breakdown, leading to low molecular weight phenolic catabolites . In some cases, these last ones are further metabolized locally and/or in other body districts (e.g., liver and kidney) before entering systemic circulation, and being then distributed and excreted .…”

Section: Absorption Uptake and Pharmacokineticsmentioning

confidence: 99%

“…Some flavanone glycosides like hesperidin and naringin, both rutinosides, are not hydrolyzed in the small intestine but in the distal part of the same by α‐rhamnosidases originating from some resident bacteria. Recently, the catabolism of Citrus flavanones by the probiotics Bifidobacterium longum and Lactobacillus rhamnosus was investigated . The authors showed, as the two bacterial strains investigated possess enzymes, which may be involved in the catabolism of orange juice flavanones in vivo .…”

Section: Absorption Uptake and Pharmacokineticsmentioning

confidence: 99%

“…Particularly, they showed as the cleavage of the rutinoside group from the flavanones skeleton is mediated by L. rhamnosus as well as both L. rhamnosus and B. longum are able to catalyze ring fission of hesperetin and naringenin. The same strains are involved also in the further demethylation and dehydroxylation steps, yielding phenylpropionic acids which may be more bioavailable and more bioactive than the parent compounds .…”

Section: Absorption Uptake and Pharmacokineticsmentioning

confidence: 99%

See 2 more Smart Citations

Flavanones: Citrus phytochemical with health‐promoting properties

et al. 2017

View full text Add to dashboard Cite

Citrus fruit and juices represent one of the main sources of compounds with a high potential for health promoting properties. Among these compounds, flavanones (such as hesperetin, naringenin, eriodictyol, isosakuranetin, and their respective glycosides), which occur in quantities ranging from ∼180 to 740 mg/L (depending on the Citrus species and cultivar) are responsible for many biological activities. These compounds support and enhance the body's defenses against oxidative stress and help the organism in the prevention of cardiovascular diseases, atherosclerosis, and cancer. Moreover, among other properties, they also show anti-inflammatory, antiviral, and antimicrobial activities. This review analyzes the biochemistry, pharmacology, and biology of Citrus flavanones, emphasizing the occurrence in Citrus fruits and juices and their bioavailability, structure-function correlations and ability to modulate signal cascades both in vitro and in vivo. © 2017 BioFactors, 43(4):495-506, 2017.

show abstract

Section: Absorption Uptake and Pharmacokineticsmentioning

confidence: 99%

Section: Absorption Uptake and Pharmacokineticsmentioning

confidence: 99%

Section: Absorption Uptake and Pharmacokineticsmentioning

confidence: 99%

See 1 more Smart Citation

Flavanones: Citrus phytochemical with health‐promoting properties

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Despite being strongly associated with citrus flavanone consumption, phenylhydracrylic acids do not seem to be produced during in vitro flavanone fermentations [15,157], suggesting that they are either purely endogenous metabolites, or at least a microbial catabolite which requires further metabolism after absorption. Volunteer studies have established that oral neohesperidin dihydrochalcone [92] and hesperetin [29] yield 3 -hydroxy-4 -methoxyphenylhydracrylic acid, i.e.…”

Section: Controls Used In Model Fermentations Have Clearly Demonstratmentioning

confidence: 99%

“…The phenol-explorer database is a useful compilation of good quality compositional data [3], but lacks data for the transformed anthocyanins, thearubigins and unextractable (poly)phenols [14]. Since phenolic acids are mostly monomeric phenols, flavonoids contain 2 phenolic rings, and polymerised flavonoids contain multiple phenolic rings, we designate the term "(poly)phenols" to cover this group [15].…”

mentioning

confidence: 99%

Role of the small intestine, colon and microbiota in determining the metabolic fate of polyphenols

Williamson

Clifford

2017

Biochemical Pharmacology

272

172

View full text Add to dashboard Cite

Please cite this article as: G. Williamson, M.N. Clifford, Role of the small intestine, colon and microbiota in determining the metabolic fate of polyphenols, Biochemical Pharmacology (2017), doi: http://dx.doi.org/10.1016/ j. bcp.2017.03.012 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. 1Role of the small intestine, colon and microbiota in determining the metabolic fate of in the small intestine, or reaches the colon and is subject to extensive catabolism by colonic microbiota. Untransformed substrates may be absorbed, appearing in plasma primarily as methylated, sulfated and glucuronidated derivatives, with in some cases the unchanged substrate. Many of the catabolites are well absorbed from the colon and appear in the plasma either similarly conjugated, or as glycine conjugates, or in some cases unchanged.Although many (poly)phenol catabolites have been identified in human plasma and / or urine, the pathways from substrate to final catabolite, and the species of bacteria and enzymes involved, are still scarcely reported. While it is clear that the composition of the human gut microbiota can be modulated in vivo by supplementation with some (poly)phenol-rich commodities, such modulation is definitely not an inevitable consequence of supplementation, it depends on the treatment, length of time and on the individual metabotype, and it is not clear whether the modulation is sustained when supplementation ceases. Some catabolites have been recorded in plasma of volunteers at concentrations similar to those shown to be effective in in vitro studies suggesting that some benefit may be achieved in vivo by diets yielding such catabolites. and are also present at high levels in supplements [4], and form essential components of many Chinese medicines [5]. A study within the European Prospective Investigation intoCancer and Nutrition (EPIC) using the Phenol Explorer database reported that the cohort studied consumed 427 different polyphenols including 94 that were consumed at a rate of >1 g/day. The estimated total polyphenol consumption ranged from 584 mg/day by Greek women to 1786 mg/day for men in Aarhus-Denmark. The corresponding data for Greek men and for Aarhus women were 744 mg/day and 1626 mg/ day, respectively, with all data adjusted for age and weighted by season and weekday of dietary recall [6]. This study defined the major contributors to be the phenolic acids (predominantly the caffeoylquinic acids (27-53%), also called chlorogenic acids) and flavonoids (predominantly flavanols (16-29%), proanthocyanidins (5-9%) and theaflavins (14-25%)) [6]. Hydroxybenzoic acids (3.3-7.4%), alkyl-phenols (1.6...

show abstract