Catabolism of pteridine cofactors

Rembold, Heinz; Chandrashekar, V.; Sudershan, P.

doi:10.1016/0304-4165(71)90332-1

Cited by 19 publications

(9 citation statements)

References 12 publications

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“…In this study urinary neopterin concentrations correlated significantly with the concentrations of total neopterins (Figure 1 if not properly protected from light and air (13). However, samples for measurement of total neopterins were handled with the necessary caution.…”

Section: Discussionmentioning

confidence: 61%

Urinary neopterin concentrations vs total neopterins for clinical utility.

et al. 1989

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Neopterin measurements are especially useful as an early marker in (e.g.) allograft rejections and in patients infected with human immunodeficiency virus type 1 (HIV-1). An increased concentration of total neopterins (neopterin + dihydroneopterin) is also a significant marker in patients with HIV-1 infection. In this study we compared concentrations of neopterin and total neopterins in urine samples from 77 homosexual men with and 73 without established HIV-1 infection. HIV-1-seropositive homosexual men had higher concentrations of neopterin and total neopterins (and 7,8-dihydroneopterin) in their urine than did those who were HIV-1-seronegative, and there was a close correlation between neopterin and total neopterins. Both neopterin variables correlated inversely with CD4+ T-cell counts and CD4+/CD8+ T-cell ratios but not with CD8+ T-cell counts in the HIV-1-seropositive men. Our data indicate that measurements of neopterin and total neopterins are of almost equal potential for clinical diagnosis. However, when measuring total neopterins, which includes oxidation of 7,8-dihydroneopterin to neopterin, more strict requirements of sample collection and handling are necessary to avoid degradation of the 7,8-dihydro derivative.

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Section: Discussionmentioning

confidence: 61%

Urinary neopterin concentrations vs total neopterins for clinical utility.

et al. 1989

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“…Levy and M c N~t t [ '~, 591 examined the degradation of pteridines by the organism Alcaligenes faecalis and found that starting with the simple pteridines isoxanthopterin (38) and xanthopterin (3s) a series of deaminations and oxidations yielded the same lumazine derivatives as noted in the studies conducted with rats. However, Alcaligenes was able to proceed one step further and convert the 6,7-dihydroxylumazine (34) into its isomer xanthine-8-carboxylic acid (36), i.e.…”

Section: Catabolismmentioning

confidence: 80%

“…found that pterin (3) occurs in the ry2 mutant of Drosophila rnelanogaster which lacks xanthine oxidase while the wild strain has isoxanthopterin (38) found that worker bees accumulated 7-hydroxylumazine (see Table 1). Drone honeybees apparently utilize 7,8-dihydrolumazine while worker bees use lumazine to form their end products.…”

Section: Forrest Etmentioning

confidence: 97%

“…Tsujitu and S a k u~u $~'~ have shown that in Bombyx larvae pteridines and purines are bound to specific proteins and are localized in integument pteridine granules. There are specific binding proteins for uric acid, sepiapterin (7b), and isoxanthopterin (38). It is not yet 0 n (38) (30) ID = isoxanthopterin deaminase known if such proteins exist also for deaminated sepiapterin and for 7-hydroxylumazine which are the other two pteridines found in Bombyx.…”

Section: Hydrogenated Pterins In Cellular Electron Transportmentioning

confidence: 98%

“…After much experimental difficulty Purrmunn was finally able in 1940 to determine the structure of these natural pigments, which were named xanthopterin (35) and leucopterin (37). At the same time he also elucidated the structure of a related pigment called isoxanthopterin (38) [41.…”

Section: Introductionmentioning

confidence: 99%

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Biochemistry of the Pteridines

Rembold

Gyure

1972

Angew. Chem. Int. Ed. Engl.

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Biochemical information about the ubiquitous pteridines has become generally available only within the last fifteen years. This delay can be traced to the chemical lability of these compounds and their small concentrations in organisms. New methods of isolation and isotopic techniques have provided data on the biosynthesis, anabolism, and catabolism of this class of compounds. Hydrogenated pteridines are recognized today as cofactors for various mixed function oxygenases and are involved in cellular electron transport. Further unknown catalytic functions for pteridines in cellular metabolism are indicated by their physiological activity, negative redox potentials, and histoautoradiographic data.

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Biochemie der Pteridine

Rembold

Gyure

1972

Angewandte Chemie

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Chemische Labilitat und eine zumeist ungewohnlich niedrige biologische Konzentration sind die Hauptgriinde, warum die Biochemie der offenbar ubiquitaren Pteridine erst im Verlauf der letzten funfzehn Jahre experimentell zuganglich wurde. Neben schonenden Isolierungsmethoden brachte vor allem die Isotopentechnik Erkenntnisse uber Biosynthese, Anabolismus und Katabolismus dieser Stoflklasse. Hydrierte Pterine sind Cofaktoren mehrerer mischfunktioneller Oxygenasen und sind am zellularen Elektronentransport beteiligt. Das physiologische Verhalten, das negative Redoxpotential und histoautoradiographische Daten sprechen fur eine Rcihe weiterer, bisher noch unbekannter katalytischer Funktionen der Pteridine im Zellstoffwechsel.

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Catabolism of pteridine cofactors

Cited by 19 publications

References 12 publications

Urinary neopterin concentrations vs total neopterins for clinical utility.

Urinary neopterin concentrations vs total neopterins for clinical utility.

Biochemistry of the Pteridines

Biochemie der Pteridine

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