Catalase activity of cobalt(II) complexes with N,N,N′,N′-tetrasubstituted thiocarbamoylsulfenamides

Chihichin, D. G.; Kotseruba, V. A.; Levchenko, O. A.; Маsаnоvets, G. N.; Seyfullina, I. I.; Kamalov, G. L.

doi:10.1134/s107036321305006x

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2019

2024

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Cited by 4 publications

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“…30,32,33 Small molecular complexes mimicking CAT have been developed to reduce oxidative stress in particular, in pathological conditions. [40][41][42][43][44][45] These bioinspired mimics are thus mainly mononuclear (Mn or Fe) porphyrin derivatives or dinuclear manganese complexes analogous to the active site of HemeCAT or MnCAT, respectively. 46 It has been proposed that for Mn porphyrin (MnP), the catalysis occurs via the redox couples Mn III (P)/(O)2Mn V (P) or Mn II (P)/O=Mn IV (P).…”

Section: Introductionmentioning

confidence: 99%

A Di Copper Peptidyl Complex Mimics Catalase Activity in HeLa HyPer Cells

Coulibaly¹,

Thauvin²,

Melenbacher³

et al. 2020

Preprint

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In this manuscript, we describe the implementation of a combinatorial apporach to synthesize a library of copper complexes, associated with an activity-based screening to discover the first peptidyl di copper complex mimicking CAT redox chemistry. The selected dinuclear complex was studied in detail and characterized for its CAT activity i<i>n vitro</i> and in cells. Very interestingly, despite moderate intrinsic catalysis constant, this complex was efficacious in a cellular assay.<br>

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