Catalase Deficiency and Type 2 Diabetes

Góth, László

doi:10.2337/dc08-1607

Cited by 74 publications

(40 citation statements)

References 6 publications

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“…The onset of diabetes for catalase deficient patients (43.1±10.9 years) appeared more than 10 years earlier (P0.001) than for the normocatalasemic subjects (56.3±11.2 years) [26]. Abbreviations: A* Type 1 n:1, Type 2 n:3, H1** gestational diabetes.…”

Section: Inherited Catalase Deficiency (Acatalasemia) and Diabetes Mementioning

confidence: 99%

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Blood Catalase Activities, Catalase Gene Polymorphisms and Acatalasemia Mutations in Hungarian Patients with Diabetes Mellitus

Góth¹

2016

Glob J Obes Diabetes Metab Syndr

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Introduction: Catalase decomposes hydrogen peroxide into oxygen and water. Its low concentration could be involved in signaling while its high concentration is toxic.Aim: This short review discusses the association of blood catalase and diabetes mellitus in Hungarian diabetic patients.Results: Several cohort studies showed decreased blood catalase activity in type 2 diabetes and in gestational diabetes.Among the catalase gene polymorphisms rs769217 showed a weak association with type 1 diabetes. Regarding rs1001179 polymorphism patients with TT genotype have a risk for lower life expectancy.In acatalasemics the frequency of diabetes mellitus is higher (P˂0.001) than in the Hungarian population. 11 of 12 known Hungarian acatalasemia mutations are found in diabetic patients. Acatalasemia may be associated with a higher risk for diabetes mellitus especially for its type 2 form.Acatalasemia mutations could explain the decreased (˂50%) blood catalase activities only in 17.4% of the cases. Conclusions:Blood catalase activity is decreased in type 2 and gestional diabetes. Patients with inherited catalase deficiency and known acatalasemia mutation are at higher risk of diabetes mellitus.The lifelong effect of oxidative damage on the oxidant sensitive, insulin producing pancreatic beta-cells could contribute to the manifestation of diabetes mellitus especially to type 2 form. Acatalasemia mutations could explain the reason for the catalase decrease while for the other (82.6 %) cases it remains unsolved.The decreased blood catalase activity in type 2 and gestational diabetes rather due to regulatory mechanisms than to the catalase gene mutations. Diabetes mellitus is a metabolic disorder characterized by hyperglycemia and either insufficiency of insulin secretion or diminished insulin sensitivity. Gestational diabetes occurs with variable severity in 3%-5% of all pregnancies. It is related to oxidative stress and impaired antioxidant defense [5]. Furthermore, Hur et al., conducted a web-based search for genes associated with reactive oxygen species and diabetes mellitus. This search showed that among the targets insulin was the first and catalase the second [6].There are several reports on decreased blood catalase activities in diseases of Hungarian subjects [7][8][9][10]. The main reasons for the blood catalase decrease might be caused by gene polymorphisms and mutations as well as regulatory mechanisms [11,12].

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Section: Inherited Catalase Deficiency (Acatalasemia) and Diabetes Mementioning

confidence: 99%

“…The higher (5.42±0.80 mmol/L) average glucose concentration of hypocatalasemic patients may indicate that they have a higher (3.05X) risk of type 2 diabetes than their normocatalasemic relatives (glucose: 4,83±0.46 mmol/L, risk:1.81X) [26,27].…”

Section: Inherited Catalase Deficiency (Acatalasemia) and Diabetes Mementioning

confidence: 99%

Blood Catalase Activities, Catalase Gene Polymorphisms and Acatalasemia Mutations in Hungarian Patients with Diabetes Mellitus

Góth¹

2016

Glob J Obes Diabetes Metab Syndr

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“…For example, one study reported that blood catalase activity was lowered due to the downregulation of catalase synthesis, rather than specific catalase gene mutations in type 2 diabetic patients. This was also associated with increased H 2 O 2 levels and dysfunctional insulin receptor signalling (Góth 2008).…”

Section: Catalasementioning

confidence: 97%

Oxidative Stress and Novel Antioxidant Approaches to Reduce Diabetic Complications

Tan¹,

Sharma²,

Haan³

2012

Oxidative Stress and Diseases

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“…Catalase deficiency is also associated with diabetes mellitus (Góth, 2008). This association is attributed for Hungarian hypocatalasemic patients.…”

Section: Catalase Deficiencymentioning

confidence: 99%