Catalase‐Loaded TaOx Nanoshells as Bio‐Nanoreactors Combining High‐Z Element and Enzyme Delivery for Enhancing Radiotherapy

Song, Guosheng; Chen, Yuyan; Liang, Chao; Yi, Xuan; Liu, Jingjing; Sun, Xiaoqi; Shen, Sida; Yang, Kai; Liu, Zhuang

doi:10.1002/adma.201602111

Cited by 369 publications

(273 citation statements)

References 41 publications

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“…[78] As a high-Z element, Ta possesses a large X-ray attenuation coefficient comparable to that of gold. [79][80][81] Those TaOx nanomaterials possess large X-ray attenuation ability and thus could act as a radio-sensitizer to deposit more radiation energy into cancer cells to enhance RT via Compton scattering and Auger effect. [79][80][81] Those TaOx nanomaterials possess large X-ray attenuation ability and thus could act as a radio-sensitizer to deposit more radiation energy into cancer cells to enhance RT via Compton scattering and Auger effect.…”

Section: Other Types Of Nanostructures Containing High-z Elementsmentioning

confidence: 99%

Emerging Nanotechnology and Advanced Materials for Cancer Radiation Therapy

et al. 2017

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Radiation therapy (RT) including external beam radiotherapy (EBRT) and internal radioisotope therapy (RIT) has been widely used for clinical cancer treatment. However, owing to the low radiation absorption of tumors, high doses of ionizing radiations are often needed during RT, leading to severe damages to normal tissues adjacent to tumors. Meanwhile, the RT efficacies are limited by different mechanisms, among which the tumor hypoxia-associated radiation resistance is a well-known one, as there exists hypoxia inside most solid tumors while oxygen is essential to enhance radiation-induced DNA damages. With the development in nanotechnology, there have been great interests in using nanomedicine strategies to enhance radiation responses of tumors. Nanomaterials containing high-Z elements to absorb radiation rays (e.g. X-ray) can act as radio-sensitizers to deposit radiation energy within tumors and promote treatment efficacy. Nanoscale carriers are able to deliver therapeutic radioisotopes into tumors for internal RIT, or chemotherapeutic drugs for synergistically combined chemo-radiotherapy. As uncovered in recent studies, the tumor microenvironment could be modulated by various nanomedicine approaches to overcome hypoxia-associated radiation resistance. Herein, the authors will summarize the applications of nanomedicine for RT cancer treatment, and pay particular attention to the latest development of 'advanced materials' for enhanced cancer RT.

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Section: Other Types Of Nanostructures Containing High-z Elementsmentioning

confidence: 99%

Emerging Nanotechnology and Advanced Materials for Cancer Radiation Therapy

et al. 2017

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“…12,13 A promising study documented the use of catalase enzyme-loaded bio-nanoreactors to improve local oxygenation by decomposing endogenous H 2 O 2 . 14 In addition, normalization of tumor vasculature by several antiangiogenic agents can lead to enhanced blood perfusion and lower interstitial fluid pressure, which, when used in combination with RT, can help to overcome several limitations of chemoradiotherapy with enhanced efficacy and reduced toxicity. 15 Although nanocarriers have been proposed for enhancing the therapeutic effects of antiangiogenic agents, their role in concomitant optimization of RT remains to be determined.…”

Section: Modulating Hypoxia For Enhanced Radiation Therapymentioning

confidence: 99%

Harnessing the Power of Nanotechnology for Enhanced Radiation Therapy

Goel¹,

Ni²,

Cai

2017

ACS Nano

120

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Radiotherapy has emerged as one of the first lines of treatment in oncology. The past few decades have seen dramatic changes in the delivery of radiation therapy, with dose fractionation and treatment planning being the major focuses of research. Although effective, such empirical approaches are hardly optimal, and instances of patient mortality and tumor relapse are not rare. In this Perspective, we review the emerging technologies for optimization of radiosensitization, hypoxia modulation, and combinatorial therapeutic regimes for improved treatment outcomes in preclinical tumor models, with a focus on nanotechnology-mediated approaches. Such an approach is expected to open more productive avenues in the advancement of radiation therapy compared to simply modulating the radiation dose delivered to the tumor.

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“…The catalase can enhance oxygen level in the tumour, benefiting radiotherapy performance of Ta 2 O 5 . 186 Some inorganic materials can also be employed to generate oxygen. Manganese dioxide (MnO 2 ) has high catalytic reactivity for H 2 O 2 decomposition to produce oxygen under acidic pH.…”

Section: Tumour Microenvironment Mediated Nanotherapeuticsmentioning

confidence: 99%

Nanoparticle design strategies for enhanced anticancer therapy by exploiting the tumour microenvironment

et al. 2017

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Nanovehicles can efficiently carry and deliver anticancer agents to tumour sites. Compared with normal tissue, the tumour microenvironment has some unique properties, such as vascular abnormalities, hypoxia and acidic pH. There are many types of cells including tumour cells, macrophages, immune and fibroblasts cells, fed by defective blood vessels in the solid tumour. Exploiting the tumour microenvironment can benefit the design of nanoparticles for enhanced therapeutic effectiveness. In this review article, we summarized the recent progress in various nanoformulations for cancer therapy, with special emphasis on tumour microenvironment stimuli-responsive ones. Numerous tumour microenvironment modulation strategies with promising cancer therapeutic efficacy have also been highlighted. Future challenges and opportunities of design consideration are also discussed in details. We believe that these tumour microenvironment modulation strategies offer a good chance for the practical translation of nanoparticle formulas into clinic.

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Catalase‐Loaded TaOx Nanoshells as Bio‐Nanoreactors Combining High‐Z Element and Enzyme Delivery for Enhancing Radiotherapy

Cited by 369 publications

References 41 publications

Emerging Nanotechnology and Advanced Materials for Cancer Radiation Therapy

Emerging Nanotechnology and Advanced Materials for Cancer Radiation Therapy

Harnessing the Power of Nanotechnology for Enhanced Radiation Therapy

Nanoparticle design strategies for enhanced anticancer therapy by exploiting the tumour microenvironment

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