Catalysis by zeolite leading to the construction of thiazole ring: an improved synthesis of 4-alkynyl substituted thiazoles

Arunkumar, K.; Reddy, Dinne Naresh Kumar; Chandrasekhar, K. B.; Kumar, Pramod; Kumar, K. Shiva; Pal, Manojit

doi:10.1016/j.tetlet.2012.05.062

Cited by 10 publications

(3 citation statements)

References 22 publications

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“…The main advantages of this methodology are the absence of solvents to perform the reaction, an inexpensive catalyst, and mild reaction conditions. Zeolites − are microporous crystalline aluminosilicates built from inifinitely extending a three-dimensional network of SiO 4 and AlO 4 tetrahedra that are linked together through oxygen bridges. By virtue of their structure, crystallinity, and variable stiochiometry, zeolite catalysts have well-defined pore size distributions, adjustable acidity, very high surface area, and good thermal stability .…”

Section: Introductionmentioning

confidence: 99%

Solvent-Free Syntheses of 1,5-Benzodiazepines Using HY Zeolite as a Green Solid Acid Catalyst

Jeganathan

Pitchumani

2014

ACS Sustainable Chem. Eng.

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1,5-Benzodiazepines are synthesized from 1,2-diamines and ketones catalyzed by HY zeolite at 50 °C under solvent-free conditions. This process offers an easy and efficient synthesis of substituted 1,5-benzodiazepines in high yields. The advantages of this protocol are operational simplicity, nontoxicity, low cost, easy recovery, and an environmentally benign nature. The catalyst is recovered by filtration and reused six times without significant loss in its catalytic activity. A plausible mechanism is also proposed.

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Section: Introductionmentioning

confidence: 99%

Solvent-Free Syntheses of 1,5-Benzodiazepines Using HY Zeolite as a Green Solid Acid Catalyst

Jeganathan

Pitchumani

2014

ACS Sustainable Chem. Eng.

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“…Scalacci et al [28] developed a microwave-assisted protocol for the preparation of thiazoles (39) and thiazolines (40) in high yields using catalytic PTSA (p-Toluenesulfonic acid). At higher temperatures, a mixture of compounds (39 and 40) was observed in the presence of base (Scheme 12).…”

Section: Isothiocyanatesmentioning

confidence: 99%

“…Arunkumar and coworkers [40] developed the Zeolite H-beta mediated preparation of 2-methyl-4-[(trimethylsilyl)ethynyl] thiazole (80). This product served as a vital synthon and was used in Sonogashira coupling [41] to yield 4-alkynyl substituted thiazole derivatives (Scheme 25).…”

Section: Thioamidesmentioning

confidence: 99%

An Overview of Recent Developments in the Synthesis of Substituted Thiazoles

et al. 2020

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Thiazole frame work represents a vital pharmacophore in several areas of chemistry. Consequently, several synthetic protocols to construct and functionalize this core, in an attempt to generate diverse thiazole containing architectures have been developed by various researchers across the globe. These wide range of methodologies developed will allow the access to fully decorated thiazole containing new chemical entities that can find various application in the field of medicinal chemistry, agrochemicals and material science. This review will provide an insight in to the various synthons used in construction and diversification of this core. Diversely functionalized thiazole analogs are considered as a vital azole framework present in many natural products. This prominent heterocycle also constitutes an important pharmacophore in medicinal chemistry, in agrochemicals and in molecules for material science applications. All these above‐mentioned features of thiazole necessitates the continuous development of efficient methods to access this heterocycle. Accordingly, various researchers across the globe have come up with efficient synthetic protocols in an attempt functionalize different positions of this important scaffold. This review aims at highlighting some of the latest synthetic approaches to di/tri‐substituted thiazole analogs which are known to possess a wide spectrum of biological activities.

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ChemInform Abstract: Catalysis by Zeolite Leading to the Construction of Thiazole Ring: An Improved Synthesis of 4‐Alkynyl Substituted Thiazoles.

et al. 2012

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Catalysis by zeolite leading to the construction of thiazole ring: an improved synthesis of 4-alkynyl substituted thiazoles

Cited by 10 publications

References 22 publications

Solvent-Free Syntheses of 1,5-Benzodiazepines Using HY Zeolite as a Green Solid Acid Catalyst

Solvent-Free Syntheses of 1,5-Benzodiazepines Using HY Zeolite as a Green Solid Acid Catalyst

An Overview of Recent Developments in the Synthesis of Substituted Thiazoles

ChemInform Abstract: Catalysis by Zeolite Leading to the Construction of Thiazole Ring: An Improved Synthesis of 4‐Alkynyl Substituted Thiazoles.

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