Catalysis with N‐Heterocyclic Carbenes under Oxidative Conditions

Abstract

This Concept article discusses the potential of oxidative carbene catalysis in synthesis and comprehensively covers pioneering studies as well as recent developments. Oxidative carbene catalysis can be conducted by using inorganic and organic oxidants. Applications in cascade processes, in enantioselective catalysis, and also in natural product synthesis are discussed.

Organocatalytic Reactions Enabled by N-Heterocyclic Carbenes

“…The combination of NHC catalysis with organic or inorganic oxidants has been recently reviewed by Studer. 198 …”

Kooperative Katalyse mit N‐heterocyclischen Carbenen

“…[33] Einige Gruppen haben nun Methoden entwickelt, mit denen katalytische Reaktionswege mçglich sind. [33] Einige Gruppen haben nun Methoden entwickelt, mit denen katalytische Reaktionswege mçglich sind.…”

Carbene‐Catalyzed Enantioselective Aromatic N‐Nucleophilic Addition of Heteroarenes to Ketones

“…We are interested in exploring N‐heterocyclic carbenes (NHCs) as key organic catalysts for new activations and enantioselective reactions. In the past, NHCs were mostly used to activate carbon atoms (Scheme a) . The carbon atoms were activated as either nucleophilic or electrophilic reactive centers.…”