Catalyst-free 1,3-dipolar cycloaddition of 3-nitrochromen with sodium azide: a facile method for the synthesis of 4-aryl-1,4-dihydrochromeno[4,3-d][1,2,3]triazole derivatives

Synthesis of (4S)‐4‐C‐spiro‐glycosyl‐chromeno‐[3,4‐d][1,2,3]triazoles: Biological evaluation and molecular docking investigation

“…In addition, these moieties find wide range of applications in industries such as photo‐sensitizers, dyes, agrochemicals, and commercially employed as anti‐corrosive agents (Figure 1). [ 1–9 ]…”

Phosphane‐Catalyzed [3+2] Annulation of Allenoates with 3‐Nitro‐2H‐chromenes: Synthesis of Tetrahydrocyclopenta[c]chromenes

“…Among this family of compounds, 3‐nitro‐2 H ‐chromenes are important building blocks, behaving as Michael acceptors in the reaction with nucleophiles and acting as a 2π component in cycloaddition reactions, namely 1,3‐dipolar cycloadditions . In fact, reports on the literature of 3‐nitro‐2 H ‐chromenes as dipolarophiles in the reaction with azides, azomethine ylides, azomethine imines and heteroaromatic N ‐ylides are known.…”

Assembly of fully substituted triazolochromenes via a novel multicomponent reaction or mechanochemical synthesis

“…Combining the chromene core with the 1,2,3-triazole structural motif has led to some interesting new molecules [ 16 – 31 ]. Very recently, spiro-fused triazolochromenes were found to be active as antitubercular agents [ 32 ], indicating that the development of new triazolochromenes in a straightforward manner is still of major interest.…”

“…Very recently, spiro-fused triazolochromenes were found to be active as antitubercular agents [ 32 ], indicating that the development of new triazolochromenes in a straightforward manner is still of major interest. Previously, NH -triazolochromenes were synthesized starting from 3-nitrochromenes with sodium azide [ 16 – 22 ], via intramolecular cyclization of a diazomethane group and a nitrile [ 23 ], or via our recently reported NH -triazole synthesis starting from 6-methoxyflavanone [ 24 ]. Furthermore, 1,4,5-trisubstituted 1,2,3-triazole annulated chromenes have been reported via an intramolecular arylation reaction of 1,2,3-triazoles [ 25 – 31 ].…”